Premadex 0.8mg/ml Oral Solution for Sheep

Care should be taken to avoid the following practices because they
increase the risk of development of resistance and could ultimately
result in ineffective therapy:
•
class, over an extended period of time.
•
weight or misadministration of the product.
Resistance to ivermectin (an avermectin) has been reported in
Teladorsagia
Haemonchus in sheep outside the EU. Therefore the use of this product
should be based on local (regional, farm) epidemiological information
about susceptibility of nematode and recommendations on how to limit
further selection for resistance to anthelmintics.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction
Test). Where the results of the test(s) strongly suggest resistance to a
particular anthelmintic, an anthelmintic belonging to another
pharmacological class and having a different mode of action should be
used.
There is cross-resistance with other avermectins and with milbemycins

(i)Special precautions for use in animals
The timing of treatment should be based on epidemiological factors and
should be customised for each individual farm. A dosing programme
should be established by the veterinary surgeon.
Veterinary advice should be sought on appropriate dosing programmes
and stock management to achieve adequate parasite control, and to
reduce the likelihood of anthelmintic resistance developing. Veterinary
advice should also be sought if the product does not achieve the
desired clinical effect, as other diseases, nutritional disturbances or
anthelmintic resistance might be involved'.
Avermectins may not be well tolerated in non-target species. Cases of
intolerance resulting in fatalities have been reported in dogs, especially
Collies, Old English Sheep Dogs and related breeds or crosses, and
also in turtles/tortoises.

Revised: June 2018
AN: 02171/2017
(ii) Special precautions to be taken by the person administering
the veterinary medicinal product to animals
Wash hands after use. Avoid contact with skin and eyes.
Do not eat, drink or smoke while handling the product.
Wear impervious gloves when handling or administering the product.
As absorption through skin can occur, in the event of accidental skin
contact, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with
water.
(iii) Other precautions
None known.