Premadex 0.5% w/v Pour-on Solution

Cattle should not be treated when hair or hide is wet. Rain falling on cattle in less than two
hours after dosing may result in reduced efficacy. However, the efficacy of the product
against established infections of O. ostertagi is not adversely affected if the
hide is wet or if rain falls shortly after treatment.
Do not apply to areas of skin that may have mange scabs or other lesions or to areas
contaminated with mud or manure.
Care should be taken to avoid the following practices because they increase the risk of
development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended
period of time.
- Underdosing, which may be due to underestimation of body weight, misadministration
of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using
appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s)
strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to
another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in Ostertagia ostertagi
use of this product should be based on local (region, farm) epidemiological information
about susceptibility of this helminth species and recommendations on how to limit further
selection for resistance to anthelmintics.

Revised: September 2025
AN: 01811/2025

Special precautions for use in animals
Ivermectins may not be well tolerated in all non-target species. Cases of intolerance with
fatal outcome are reported in dogs, especially Collies, Old English Sheepdogs and related
breeds or crosses, and also in turtles/tortoises. To avoid secondary reactions due to the
death of
administer the product at the end of the period of warble fly activity and before the larvae
reach their resting site. As Ivermectin is extremely dangerous to fish and aquatic life,
treated animals should not have direct access to surface water and ditches during
treatment.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
The product may be irritating to human skin and eyes and the user should be careful not to
apply it to himself or other persons. Operators should wear rubber gloves and boots with a
waterproof coat when applying the product. Protective clothing should be washed after
use. Use only in well-ventilated areas or outdoors.
HIGHLY FLAMMABLE.
Keep away from heat, spark, open flame or other source of ignition. Do not eat, drink or
smoke whilst handling the product.
As absorption through skin can occur, in the event of accidental skin contact the affected
area should be washed immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with water and seek medical
attention. Wash hands after use.