POM-V Prescription Required

Prellim 0.075 mg/ml Solution for Injection for Cattle and Pigs

Active ingredient: d-Cloprostenol

Form

Injection

Species

Cattle Pigs

Manufacturer

Laboratorios SYVA S.A.

VMD MA No.

31592/5003

What it's used for

Therapeutic indication: ovarian dysfunction (persistent corpus luteum, luteal cyst), interruption of pregnancy including foetal mummification, endometritis...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for d-Cloprostenol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Prellim 0.075 mg/ml Solution for Injection for Cattle and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Therapeutic indication: ovarian dysfunction (persistent corpus luteum, luteal
cyst), interruption of pregnancy including foetal mummification,
endometritis/pyometra, delayed uterine involution.
Pigs (sows)
Indications for reproduction: Induction of parturition.

- Oestrus induction (also in cows with weak or silent heat): After determining
the presence of corpus luteum (day 6-18 of the cycle), administer the
veterinary medicinal product. Heat is generally observed in 48-60 hours.
Inseminate 72-96 hours after this treatment. If heat is not observed, repeat
after 11 days.
- Parturition induction
gestation day 270. Parturition should occur 30-60 hours post-treatment.
- Oestrus synchronisation: Administer the veterinary medicinal product twice
(11 days apart). Inseminate artificially 72 and 96 hours after the second
injection.
Based on the results of clinical trials and the scientific literature, d-cloprostenol
can be used in combination with GnRH, with or without progesterone, in
ovulation synchronization protocols (Ovsynch protocols). The decision on
which protocol to use should be made by the responsible veterinarian, based
on the objectives of the treatment and depending on the herd and animals to
be treated. The following protocols have been evaluated and can be used:
In cyclical cows:
- Day 0: inject GnRH (or analog).
- Day 7: inject d-cloprostenol (2 ml of the veterinary medicinal product).
- Day 9: inject GnRH (or analog).
- Artificial insemination 16-24 hours later.
Alternatively in cyclical and non-cyclical cows and heifers:
- Day 0: insert the intravaginal progesterone releasing device and inject
GnRH (or analog).
- Day 7: remove the intravaginal device and inject d-cloprostenol (2 ml of
the veterinary medicinal product).
- Day 9: inject GnRH (or analog).
- Artificial insemination 16-24 hours later.
- Ovarian dysfunction: Once the presence of corpus luteum is determined,
administer the veterinary medicinal product and inseminate in the first heat
after the treatment. If no heat is observed, carry out a gynaecological
examination again and repeat the injection 11 days after the first treatment.
Insemination is 72-96 hours post-treatment.
-: Administer 1 dose of the veterinary medicinal
product. Repeat the treatment 10-11 days later if necessary.
- Gestation interruption: Administer the veterinary medicinal product during
the first half of gestation.
-: Administer 1 dose of veterinary medicinal product.
The foetus will be expelled after 3 or 4 days.
-
product and, if indicated, repeat the treatment once or twice at 24 hours
interval.
Pigs(sows): The recommended dose is 0.075 mg d-cloprostenol/animal,
equivalent to 1 ml/animal.
- Parturition induction: Administer the veterinary medicinal product after day
112 of gestation. Repeat after 6 hours. Alternatively, 20 hours after the initial
dose of d-cloprostenol, a myometrial stimulant (oxytocin or carazolol) may be
administered. Following the protocol of double administration, in about 70% of
cases, parturition occurs 20-30 hours after the first treatment.

See section 4.7
Do not use in cases of hypersensitivity to the active substance, or to any of the
excipients.
Do not use in animals with spastic respiratory or gastro-intestinal diseases.

Cattle and pigs
Very rare
(< 1 animal / 10,000 animals
treated, including isolated
reports)
Application site reaction
Injection site swelling
Injection site gaseous gangrene
Typical local reactions due to anaerobic infection applies in particular to cows.
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See also the last section of the package leaflet for respective contact
details.

None.

i) Special precautions for use in animals
As with parenteral administration of any substance, basic antiseptic rules should
be observed. The injection site must be thoroughly cleaned and disinfected in
order to reduce the risk of infection with anaerobic bacteria.
Pigs: use only when precise date of insemination is known. Administer on day
113 of gestation, at the earliest. The veterinary medicinal product administered
earlier, may impair the viability and weight of piglets.
ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
d-Cloprostenol, like all F2 prostaglandins, can be absorbed through the skin
and can produce bronchospasm and abortion.
Direct contact with skin or mucous membranes of the user should be avoided.
Pregnant women, women of child-bearing age, asthmatics and persons with
bronchial problems or any other type of respiratory problem must avoid any
contact or use disposable plastic gloves when administering the veterinary
medicinal product.
The veterinary medicinal product must be handled carefully to avoid
ACCIDENTAL SELF-INJECTION OR SKIN CONTACT.
In case of accidental self injection seek medical advice immediately and show
the package leaflet or the label to the physician.
Seek medical advice immediately in case of any respiratory difficulty caused by
accidental inhalation or inoculation.
In case of accidental skin contact, wash with soap and water immediately.
Do not eat, drink or smoke while handling the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
iii) Other precautions
Not applicable

interaction
Do not use in animals being treated with non-steroidal anti-inflammatories, as
the synthesis of endogenous prostaglandins is inhibited.
The activity of other oxytocic agents can be increased after the administration of
Cloprostenol.

Keep the vial in the outer carton in order to protect from light.

Cows:
Milk: Zero hours.
Sows:
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.