POM-V Prescription Required

Dalmaprost 0.075 mg/ml Solution for Injection for Cattle, Pigs and Horses

Active ingredient: d-Cloprostenol

Form

Injection

Species

Cattle Horses Pigs

Manufacturer

Fatro S.p.A.

VMD MA No.

11557/4006

What it's used for

• • • • of GnRH or analogue) Sows • Mares •

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for d-Cloprostenol

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

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Clinical information

Dalmaprost 0.075 mg/ml Solution for Injection for Cattle, Pigs and Horses — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

•
•
•
•
of GnRH or analogue)
Sows
•
Mares
•

COWS:
Administer one dose (2 ml) per animal of veterinary medicinal product (equivalent to 150 g
of d-cloprostenol per animal):
-
of the veterinary medicinal product after having established the presence of a
luteum
with insemination 72-96 hours after injection. If oestrus is not evident, administration
of the veterinary medicinal product needs to be repeated 11 days after the first
injection.
-
twice (with an interval of 11 days between each dose). Proceed therefore with two
artificial inseminations at intervals of 72 and 96 hours from the second injection.
D-cloprostenol may be used in combination with GnRH, with or without progesterone,
in the protocols for synchronization of the ovulation (Ovsynch protocols). The
responsible veterinarian shall decide the protocol to be used, basing on the objective
AN: 00247/2025 & 00250/2025Page 5 of 8
of the treatment, and on the herd and animals to be treated. The following protocols
have been evaluated and may be used:
In cycling cows:
-
-
-
-
Alternatively in cycling or not-cycling cows and heifers:
-
(or analogous).
-
veterinary medicinal product).
-
-
-
Birth usually occurs within 30-60 hours of treatment.
-, luteal cyst): once a
luteum
and inseminate at the first oestrus after injection. If oestrus is not evident, conduct a
further gynaecological examination, and repeat the injection 11 days after the first
administration. Insemination must be carried out 72-96 hours after injection.
-,
pyometra
repeat the treatment after 10 days.
-
and, if considered necessary, carry out one or two successive treatments at 24 hours
intervals.
-: administer one dose of the veterinary medicinal product in
the first half of pregnancy.
-
administration of one dose of the veterinary medicinal product.
MARES:
For the induction of luteolysis in mares with a functional : administer a single
injection of 1 ml of veterinary medicinal product/animal (equivalent to 75 of d-
cloprostenol).
SOWS:
For the nduction of parturition in sows: administer 1 ml of the veterinary medicinal product,
equivalent to 75 micrograms of d-cloprostenol/animal, by intramuscular route, not earlier
than 114 days of pregnancy. The injection can be repeated after 6 hours.
AN: 00247/2025 & 00250/2025Page 6 of 8The stopper of the vial can be safely punctured up to 20 times. Otherwise, for the 100 ml
vials automatic syringe equipment, or a suitable draw-off needle, should be used to prevent
excessive puncture of the closure.

Do not use in pregnant females, unless it is desirable to induce parturition or induction of
abortion.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not administer to animals with cardiovascular, respiratory or gastrointestinal problems.
Do not administer to induce parturition in sows and cows with suspected dystocia due to
mechanical obstruction or if problems are expected because of an abnormal position of the
foetus.

Cattle (cows):
Common
(1 to 10 animals / 100 animals
treated):
Injection site infection
(Injection site swelling,
Crepitus)
Undetermined frequency (cannot
be estimated from the available
data):
Retained placenta
1
Due to anaerobic infection, especially after intramuscular injection.
May increase when used for induction of parturition and depending on the moment of
treatment relative to the date of conception.
Pigs (sows)
Common
(1 to 10 animals / 100 animals
treated):
Injection site infection
(Injection site swelling,
Crepitus)
Undetermined frequency (cannot
be estimated from the available
data):
Retained placenta
Behavioural disorders
1
Due to anaerobic infection, especially after intramuscular injection.
May increase when used for induction of parturition and depending on the moment of
treatment relative to the date of conception
Observed after treatment for induction of farrowing. The changes are similar to those
changes associated with natural farrowing and usually cease within 1 hour.
Horses (mares):
Common
(1 to 10 animals / 100 animals
treated):
Injection site infection
(Injection site swelling,
Crepitus)
Undetermined frequency (cannot
be estimated from the available
data):
Retained placenta
Increased sweating
3,4
Increased respiratory rate
Increased heart rate
AN: 00247/2025 & 00250/2025Page 4 of 8
Abdominal discomfort
, Watery diarrhoea
Depression
1
Due to anaerobic infection, especially after intramuscular injection.
May increase when used for induction of parturition and depending on the moment of
treatment relative to the date of conception.
Occurring within 20 minutes of treatment.
May occur when exceptionally high doses are given. However adverse reactions are
usually mild and transient.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary
medicinal product. Reports should be sent, preferably via a veterinarian, to either the
marketing authorisation holder or its local representative or the national competent authority
via the national reporting system. See the package leaflet for respective contact details.

The response of cows to the synchronization protocols is not homogenous nor between the
herds, neither within the same herd, and may vary depending on the physiological state of
the animal at the time of treatment (sensitivity and a functional state of the ,
age, physical condition, interval from calving, etc.).

Special precautions for safe use in the target species:
Induction of parturition and abortion may increase the risk of complications, retained
placenta, foetal death and metritis.
To reduce the risk of anaerobic infections, which might be related to the pharmacological
properties of prostaglandins, care should be taken to avoid injection through contaminated
areas of skin. Clean and disinfect injection sites thoroughly before administration.
In case of oestrus induction in cows: from the 2nd day after injection, adequate heat
detection is necessary.
Induction of parturition in sows before day 114 of gestation may result in an increased risk
of stillbirths and the need for manual assistance at farrowing.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Prostaglandins of the type can be absorbed through the skin and may cause
bronchospasm or miscarriage.
Care should be taken when handling the veterinary medicinal product to avoid self-injection
or skin contact.
AN: 00247/2025 & 00250/2025Page 3 of 8
Pregnant women, women of child-bearing age, asthmatics and people with bronchial or
other respiratory problems, should avoid contact when handling this veterinary medicinal
product or personal protective equipment consisting of disposable impervious-gloves should
be worn when administering the veterinary medicinal product.
In case of accidental spillage onto skin, seek medical advice immediately and show the
package leaflet or the label to the physician.
Accidental spillage on the skin should be washed off immediately with soap and water.
Should shortness of breath result from accidental inhalation or injection, seek medical advice
and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

Do not administer the veterinary medicinal product together with nonsteroidal anti-
inflammatory drugs since they inhibit endogenous prostaglandin synthesis. The activity of
other oxytocic agents can be increased after the administration of the veterinary medicinal
product.

Store below 25 °C.
Keep the vial in the outer carton in order to protect from light.

Cattle
Meat and offal: Zero days.
Milk: Zero hours.
Pigs
Meat and offal: 1 day.
Horses
Meat and offal: 2 days.
Milk: Zero hours.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.