Alizin 30 mg/ml Solution for Injection for Dogs

Rare cases of lack of efficacy (>0.01 % to < 0.1%) have been reported as part of the
pharmacovigilance survey. To reduce the possibility of lack of expected efficacy,
avoid the use of Alizin until after the end of oestrus and avoid new mating before the
end of oestrus.
In bitches confirmed pregnant, a partial abortion was observed in 5% of cases in field
trials. A thorough clinical examination is always recommended in order to confirm that
the uterus content is fully evacuated. Ideally, the examination should be conducted
using ultrasound. This examination should be performed 10 days after treatment and
at least 30 days after mating.
In case of partial abortion or no abortion, repeat treatment may be recommended
10 days after treatment, between day 30 and day 45 after mating. Surgery should
also be considered.

Special precautions for safe use in the target species:
In the absence of available data, the veterinary medicinal product should be used
with caution in dogs with chronic obstructive-airway disease and/or cardiovascular
disease, particularly bacterial endocarditis.
Fatalities have been reported subsequent to off-label use in seriously ill bitches with
uterine infections. A causal association is difficult to determine but is unlikely.
In up to 50 % of bitches, mating may not be followed by pregnancy. The possibility
that a bitch may therefore be treated unnecessarily should be taken into account in
evaluating the veterinary medicinal product risk-benefit ratio.
Bitches that remain pregnant despite treatment should be monitored, as viability of
the puppies may be compromised and serious complications such as dystocia and
uterine rupture could result from abortion failure.
Possible long-term effects of treatment have not been studied.
Owners should be advised to consult their veterinary surgeon if their dog shows the
following signs after treatment with the veterinary medicinal product:
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Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Nor-steroids are used in humans to induce abortion. Accidental injection may be a
particular hazard to women who are pregnant, intending to become pregnant or

Amended pages: January 2026
whose pregnancy status is unknown. Care should be taken by the veterinary surgeon
when handling the veterinary medicinal product and the person restraining the dog to
avoid accidental injection. Pregnant women should administer the veterinary
medicinal product with caution. This is an oil-based veterinary medicinal product that
may cause prolonged local reactions at the site of injection. In case of accidental self-
injection, ingestion, spillage onto skin and/or eyes, seek medical advice immediately
and show the package leaflet or the label to the physician.
Women of child-bearing age should avoid contact with the veterinary medicinal
product or wear disposable plastic gloves when administering the veterinary
medicinal product.
Special precautions for the protection of the environment:
Not applicable.