POM-V Prescription Required

Genestran 75 micrograms/ml Solution for Injection for Cattle, Horses and Pigs

Active ingredient: d-Cloprostenol

Form

Injection

Species

Cattle Horses Pigs

Manufacturer

aniMedica GmbH

VMD MA No.

24745/5002

What it's used for

Horses: - induction of luteolysis in mares with a functional corpus luteum. AN: 03990/2025 + 04268/2025 Pigs: - induction or synchronisation of farrowing (...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for d-Cloprostenol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Genestran 75 micrograms/ml Solution for Injection for Cattle, Horses and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Horses:
- induction of luteolysis in mares with a functional corpus luteum.
AN: 03990/2025 + 04268/2025
Pigs:
- induction or synchronisation of farrowing (generally within 24 to 36 hours) from day 113 of
pregnancy onwards (day 1 of pregnancy is the last day of natural or artificial insemination).

Cattle:
2.0 ml (150
Induction of oestrus: two days following administration, close observation of the
oestrus is advised.
Synchronisation of oestrus: animals are to be treated twice within 11 days.
Horses:
0.3- 0.5 ml (22.5 - 37.5
Intended for single use.
Pigs:
0.7- 1.0 ml (52.5 - 75
Intended for single use.
The stopper should not be pierced more than 70 times.
AN: 03990/2025 + 04268/2025

Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not use in animals with spastic respiratory or gastro-intestinal diseases.
Do not use in pregnant animals, for which induction of abortion or parturition is not intended.
Do not use for intravenous administration.

Cattle:
Undetermined frequency (cannot
be estimated from the available
data):
Injection site inflammation
Injection site infection
Retained placenta
AN: 03990/2025 + 04268/2025
Anaerobic infections may occur after introduction of anaerobic bacteria into the tissue by
intramuscular injection.
Following induction of parturition.
Horses:
Undetermined frequency (cannot
be estimated from the available
data):
Injection site inflammation
Injection site infection
Increased sweating
Diarrhoea
1
Anaerobic infections may occur after introduction of anaerobic bacteria into the tissue by
intramuscular injection.
Slight; temporarily.
Pigs:
Undetermined frequency (cannot
be estimated from the available
data):
Injection site inflammation
Injection site infection
1
Anaerobic infections may occur after introduction of anaerobic bacteria into the tissue by
intramuscular injection.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details..

None.

Special precautions for safe use in the target species:
To reduce the risk of anaerobic infections, which might be related to the pharmacological
properties of prostaglandins, care should be taken to avoid injection through contaminated
areas of skin. Clean and disinfect injection sites thoroughly before application.
Avoid contamination of the veterinary medicinal product during use. Should any apparent
growth or discoloration occur, the veterinary medicinal product should be discarded.
Pigs:
gestation, at the
earliest. The veterinary medicinal product administered earlier, may impair the viability and
weight of piglets.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
The veterinary medicinal product must be handled carefully to avoid accidental self-
injection and direct contact with the skin or mucous membranes of the user. Prostaglandins
of the F2 type may be absorbed through the skin and may cause bronchospasm or
miscarriage. Pregnant women, women of childbearing age, asthmatics and persons with
other respiratory tract diseases should exercise caution when handling the veterinary
medicinal product. Those persons should wear gloves during administration of the
veterinary medicinal product. Accidental spillage on the skin should be washed immediately
with soap and water. In case of accidental self-injection, seek medical advice immediately
and show the package leaflet or the label to the physician. Should respiratory distress result
from accidental inhalation or injection, a rapid acting bronchodilator, e.g. isoprenaline or
salbutamol by inhalation is indicated.
Special precautions for the protection of the environment:
Not applicable.

Concurrent use of oxytocin and cloprostenol increases the effects on the uterus.

Keep the vial in the outer carton in order to protect from light.

Cattle and horses:
Meat and offal: 1 day.
Milk: zero hours.
Pigs:
Meat and offal: 1 day.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.