Nexmectin 18.7 mg/g Oral Paste for Horses

Some horses with heavy infections of Onchocerca spp. microfilariae have
experienced oedema and pruritus following treatment, such reactions are assumed to
be the result of death of large numbers of microfilariae. These signs resolve within a
few days but symptomatic treatment may be advisable.
Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product.
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Veterinary advice should be given on appropriate dosing programs and stock
management to achieve adequate parasite control and reduce the likelihood of
anthelmintic resistance developing. In the event that a product is suspected of being
ineffective, the animal owner is advised to seek veterinary advice.
Resistance to ivermectin has been reported in Parascaris equorum. Therefore, the
use of this product should be based on local farm epidemiological information about
susceptibility of nematodes and recommendations on how to limit further selection for
resistance to anthelmintics

Special precautions for use in animals
Since ivermectin is highly bound to plasma proteins, special care should be taken in
cases of sick animals or in nutritional conditions associated with low plasma protein
levels.

Revised: August 2025
AN: 01416/2025
Dogs and cats should not be allowed to ingest spilled gel or have access to used
packaging due to the potential for adverse effects related to ivermectin toxicity
The product has been formulated for use in horses only. Cats, dogs (especially
Collies, Old English Sheepdogs and related breeds or crosses) and also turtles and
tortoises may be adversely affected by the concentration of ivermectin in this product
if they are allowed to ingest spilled paste or have access to used syringes.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Do not smoke, eat or drink while handling the product.
Wash hands after use.
This product may cause skin and eye irritation. Therefore, the user should avoid
contact of the product with the skin and the eyes. In case of contact, rinse
immediately with plenty of water.
In the case of accidental ingestion or eye irritation after contact seek medical advice
immediately and show the package leaflet or the label to the physician.