Ivermectin Pour-on Solution for Cattle 5 mg/ml Virbac

Assess bodyweight as accurately as possible before calculating the dosage.
Cattle should not be treated when the hair or hide is wet. Rain falling on
animals less than two hours after dosing may result in reduced efficacy.
However, under such conditions, efficacy of the product against infections of
Ostertagia ostertagi or Dictyocaulus viviparus in cattle may be maintained. The
influence of extreme weather conditions on the long-term performance
(persistent activity) of the product is not known.
Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
• Underdosing, which may be due to underestimation of body weight,
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.

Revised: April 2015
AN : 01613/2014
Resistance to ivermectin (an avermectin) has been reported in Cooperia
oncophora in cattle within the EU. Therefore the use of this product should be
based on local (regional and farm) epidemiological information about
susceptibility of the gastrointestinal nematodes and recommendations on how
to limit further selection for resistance to anthelmintics.

i. Special precautions for use in animals
Do not apply to areas of skin which have mange scabs or other lesions or
to areas contaminated with mud or manure.
Avermectins may not be well tolerated in all non-target species. Cases of
intolerance with fatal outcome are reported in dogs, especially collies, old
English sheepdogs and related breeds or crosses and also in
turtles/tortoises.
The product is effective in all hypodermosis stages. However, it is
important to treat on time (at the end of warble-fly season). The
elimination of Hypoderma larvae may cause negative reactions on the
host, when they are found in vital areas. Killing Hypoderma lineatum, if
found in perioesophageal tissue, may cause salivation and tympanism.
Killing Hypoderma bovis, if found in the vertebral canal, may cause
unsteadiness or paralysis. Cattle should be treated before or after those
stages of warble flies.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
HIGHLY FLAMMABLE - keep away from heat, sparks, open flame or
other sources of ignition.
The product may be irritating to human skin and eyes and the user should
be careful not to apply it to himself or other persons. Operators should
wear nitrile rubber gloves, rubber boots and a waterproof coat when
applying the product. Protective clothing should be washed after use.
If accidental skin contact occurs, wash the affected area immediately with
soap and water. If accidental eye exposure occurs, flush the eyes
immediately with water and get medical attention.
Do not smoke, drink or eat while handling the product.
Wash hands after use.
Use only in well-ventilated areas or outdoors.
iii. Other precautions
Treated cattle should not have direct access to ponds, streams or ditches
for 14 days after treatment.