NFA-VPS
Over the Counter
Companion Animal
Frontline Tri-Act Spot-on Solution for Dogs 2-5 kg
Active ingredients: Fipronil, Permethrin (Cis:Trans 40:60)
Form
Spot-on
Species
Dogs
Manufacturer
Boehringer Ingelheim Animal Health UK Limited
VMD MA No.
08327/5068
What it's used for
In dogs: For the treatment and prevention of flea (killing effect) and/or tick (killing and repellent effects) infestations where repellent activity is nec...
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Clinical information
Frontline Tri-Act Spot-on Solution for Dogs 2-5 kg — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
In dogs:
For the treatment and prevention of flea (killing effect) and/or tick (killing and
repellent effects) infestations where repellent activity is necessary against
mosquitoes, sandflies and/or biting flies.
•
Treatment and prevention of Ctenocephalides felis flea infestations and prevention of
Ctenocephalides canis flea infestations. One treatment prevents new flea
infestations for 4 weeks.
The product can be used as part of a treatment strategy for flea allergy dermatitis
where this has been previously diagnosed by a veterinarian.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
•
Treatment and prevention of tick infestations (Dermacentor reticulatus, Ixodes
ricinus, Rhipicephalus sanguineus). One treatment kills (Dermacentor reticulatus,
Ixodes ricinus, Rhipicephalus sanguineus) and repels (Ixodes ricinus, Rhipicephalus
sanguineus) ticks for 4 weeks after treatment, and repels Dermacentor
reticulatus
from 7 days up to 4 weeks after treatment.
•
Repels (anti-feeding activity) sandflies (Phlebotomus perniciosus) for 3 weeks and
mosquitoes (Culex pipiens, Aedes albopictus) for 4 weeks.
Kills sandflies (Phlebotomus perniciosus) and mosquitoes (Aedes albopictus)
weeks
•
Repels (anti-feeding activity) and kills stable flies (Stomoxys calcitrans) for 5 weeks.
For the treatment and prevention of flea (killing effect) and/or tick (killing and
repellent effects) infestations where repellent activity is necessary against
mosquitoes, sandflies and/or biting flies.
•
Treatment and prevention of Ctenocephalides felis flea infestations and prevention of
Ctenocephalides canis flea infestations. One treatment prevents new flea
infestations for 4 weeks.
The product can be used as part of a treatment strategy for flea allergy dermatitis
where this has been previously diagnosed by a veterinarian.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
•
Treatment and prevention of tick infestations (Dermacentor reticulatus, Ixodes
ricinus, Rhipicephalus sanguineus). One treatment kills (Dermacentor reticulatus,
Ixodes ricinus, Rhipicephalus sanguineus) and repels (Ixodes ricinus, Rhipicephalus
sanguineus) ticks for 4 weeks after treatment, and repels Dermacentor
reticulatus
from 7 days up to 4 weeks after treatment.
•
Repels (anti-feeding activity) sandflies (Phlebotomus perniciosus) for 3 weeks and
mosquitoes (Culex pipiens, Aedes albopictus) for 4 weeks.
Kills sandflies (Phlebotomus perniciosus) and mosquitoes (Aedes albopictus)
weeks
•
Repels (anti-feeding activity) and kills stable flies (Stomoxys calcitrans) for 5 weeks.
For external use.
The recommended minimum dose is 6.76 mg fipronil/kg bodyweight, and 50.48
mg/kg permethrin equivalent to 0.1 ml spot-on solution per kg bodyweight.
The use of the product should be based on a confirmed infestation or risk of
infestation with fleas and/or ticks when repellent activity is also necessary against
mosquitoes, sandflies and/or biting flies. Depending on the ectoparasite challenge
repetition of the treatment might be indicated. In such instances, the interval between
two treatments should be at least 4 weeks.
Method of administration:
Spot-on use.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
Select the appropriate pipette size for the weight of the dog. For dogs over 60 kg,
use the appropriate combination of two pipette sizes that most closely matches the
bodyweight.
The product should be applied in two out-of-reach spots so that the dog cannot lick
the application site. These sites are at the base of the neck in front of the shoulder
blades and the middle of the neck between the base of the skull and the shoulder
blades.
Remove the blister card from the package and separate one blister. Remove the
pipette by cutting along the dotted line with a pair of scissors or tearing open after
folding the marked corner. Holding the pipette upright away from face and body, cut
the pipette tip with scissors to open. Part the coat on the back of the dog until the
skin is visible. Place the tip of the pipette on the skin. Squeeze the pipette, applying
about half of the contents half way down the neck between the base of the skull and
the shoulder blades. Repeat the application at the base of the neck in front of the
shoulder blades to empty the pipette. For best results, ensure that the product is
applied directly to the skin rather than on the hair.
The recommended minimum dose is 6.76 mg fipronil/kg bodyweight, and 50.48
mg/kg permethrin equivalent to 0.1 ml spot-on solution per kg bodyweight.
The use of the product should be based on a confirmed infestation or risk of
infestation with fleas and/or ticks when repellent activity is also necessary against
mosquitoes, sandflies and/or biting flies. Depending on the ectoparasite challenge
repetition of the treatment might be indicated. In such instances, the interval between
two treatments should be at least 4 weeks.
Method of administration:
Spot-on use.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
Select the appropriate pipette size for the weight of the dog. For dogs over 60 kg,
use the appropriate combination of two pipette sizes that most closely matches the
bodyweight.
The product should be applied in two out-of-reach spots so that the dog cannot lick
the application site. These sites are at the base of the neck in front of the shoulder
blades and the middle of the neck between the base of the skull and the shoulder
blades.
Remove the blister card from the package and separate one blister. Remove the
pipette by cutting along the dotted line with a pair of scissors or tearing open after
folding the marked corner. Holding the pipette upright away from face and body, cut
the pipette tip with scissors to open. Part the coat on the back of the dog until the
skin is visible. Place the tip of the pipette on the skin. Squeeze the pipette, applying
about half of the contents half way down the neck between the base of the skull and
the shoulder blades. Repeat the application at the base of the neck in front of the
shoulder blades to empty the pipette. For best results, ensure that the product is
applied directly to the skin rather than on the hair.
Do not use on sick or convalescent animals.
This product is for use on dogs only. Do not use in cats and rabbits, as adverse
reactions and even death could occur (see also section 4.5)
.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients (see also section 4.5).
This product is for use on dogs only. Do not use in cats and rabbits, as adverse
reactions and even death could occur (see also section 4.5)
.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients (see also section 4.5).
Transient skin reactions at
the
application site (skin discolouration, local hair loss,
itching, redness) and
general
itching, hair loss and erythema (redness) have been
reported very rarely after use.
Reversible
nervous signs (increased sensitivity to
stimulation, hyperactivity, muscle tremor, lethargy, ataxia (loss of coordination), other
nervous
signs), vomiting, anorexia (not eating) and hypersalivation have also been
reported very rarely after
use.
If licking of the application site occurs, transient hypersalivation and emesis (vomiting)
may be observed.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
the
application site (skin discolouration, local hair loss,
itching, redness) and
general
itching, hair loss and erythema (redness) have been
reported very rarely after use.
Reversible
nervous signs (increased sensitivity to
stimulation, hyperactivity, muscle tremor, lethargy, ataxia (loss of coordination), other
nervous
signs), vomiting, anorexia (not eating) and hypersalivation have also been
reported very rarely after
use.
If licking of the application site occurs, transient hypersalivation and emesis (vomiting)
may be observed.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
There may be an attachment of single ticks or bites by single mosquitoes or
sandflies. For this reason, transmission of pathogens by these arthropods cannot be
completely excluded if conditions are unfavorable. Single ticks may attach and
detach within the first 24 hours after infestation and if ticks are present when the
product is applied not all ticks may be killed within 48 hours after treatment.
The product remains effective against fleas when treated animals are immersed in
water occasionally (e.g
to swim or be shampooed within 48 hours after treatment. Avoid frequent swimming or
shampooing of treated dogs as this may adversely affect maintenance of product
effectiveness.
To reduce re-infestation from emergence of new fleas, it is recommended that all
dogs in a household be treated. Other animals living in the same household should
also be treated with a suitable product. To aid further in reducing environmental
challenge, the additional use of a suitable environmental treatment against adult
fleas and their developmental stages could be recommended.
Special precautions for use in
animals
In the absence of specific studies, the use of the product is not recommended in
dogs younger than 8 weeks of age, or in dogs weighing less than 2 kg.
Care should be taken to avoid contact of the veterinary medicinal product with the
dog’s eyes.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
It is important to make sure that the product is applied to an area where
the
animal cannot lick it off and to make sure that other animals do not lick the
treatment sites following application
.
Animals should be weighed accurately prior to treatment.
Seek veterinary advice if the product is accidentally ingested or comes into contact
with your dog’s eyes.
Due to the unique physiology of cats which prevents them from metabolizing certain
compounds, including permethrin, the product can induce potentially fatal
convulsions in this species. In case of accidental dermal (skin) exposure, wash the
cat with shampoo or soap, and seek veterinary advice rapidly. To prevent cats from
being accidentally exposed to the product, keep treated dogs away from cats until
the application site is dry. It is important to ensure that cats do not groom the site of
application on a dog which has been treated with this product. In case of exposure
of this type seek veterinary advice immediately.
Do not use in cats and rabbits.
Special precautions to be taken by the person administering the
veterinary
m
edicinal product to
animals
This product can cause skin and eye irritation,
therefore, avoid
contact of the
product with skin and eyes
.
Do not open the pipette near or towards the face. In
case of ocular (eye) exposure or if eyes become irritated during administration,
immediately flush the eyes with plenty of water. If ocular (eye) irritation persists, seek
medical attention. In case of dermal (skin) exposure or if skin becomes irritated
during administration, immediately wash the skin with plenty of soap and water. If
skin irritation persists or recurs, seek medical attention.
People with known hypersensitivity to fipronil and/or permethrin should avoid
contact with the product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke,
drink or eat during
application.
Wash hands after
use. If swallowed rinse mouth
and seek medical attention if you feel unwell.
Since the excipient N-methylpyrrolidone may induce foetotoxicity (toxicity to the
foetus) and teratogenicity (embryonic or foetal malformation) after significant
exposure, pregnant women should wear gloves to avoid contact with the product.
Treated animals should not be handled until the application site is dry,
and
children should not be allowed to play with treated animals until the application site
is dry. It is therefore recommended that animals are not treated during the day, but
should be treated during the early evening,
and
that recently treated animals are
not allowed to sleep with owners,
especially children.
Keep the stored pipettes in the original blister and once used, the empty pipette
should immediately be disposed of appropriately, preventing further access.
Other precaution
The product may adversely affect aquatic organisms. Treated dogs should not be
allowed to enter surface water for 2 days after treatment.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
sandflies. For this reason, transmission of pathogens by these arthropods cannot be
completely excluded if conditions are unfavorable. Single ticks may attach and
detach within the first 24 hours after infestation and if ticks are present when the
product is applied not all ticks may be killed within 48 hours after treatment.
The product remains effective against fleas when treated animals are immersed in
water occasionally (e.g
to swim or be shampooed within 48 hours after treatment. Avoid frequent swimming or
shampooing of treated dogs as this may adversely affect maintenance of product
effectiveness.
To reduce re-infestation from emergence of new fleas, it is recommended that all
dogs in a household be treated. Other animals living in the same household should
also be treated with a suitable product. To aid further in reducing environmental
challenge, the additional use of a suitable environmental treatment against adult
fleas and their developmental stages could be recommended.
Special precautions for use in
animals
In the absence of specific studies, the use of the product is not recommended in
dogs younger than 8 weeks of age, or in dogs weighing less than 2 kg.
Care should be taken to avoid contact of the veterinary medicinal product with the
dog’s eyes.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
It is important to make sure that the product is applied to an area where
the
animal cannot lick it off and to make sure that other animals do not lick the
treatment sites following application
.
Animals should be weighed accurately prior to treatment.
Seek veterinary advice if the product is accidentally ingested or comes into contact
with your dog’s eyes.
Due to the unique physiology of cats which prevents them from metabolizing certain
compounds, including permethrin, the product can induce potentially fatal
convulsions in this species. In case of accidental dermal (skin) exposure, wash the
cat with shampoo or soap, and seek veterinary advice rapidly. To prevent cats from
being accidentally exposed to the product, keep treated dogs away from cats until
the application site is dry. It is important to ensure that cats do not groom the site of
application on a dog which has been treated with this product. In case of exposure
of this type seek veterinary advice immediately.
Do not use in cats and rabbits.
Special precautions to be taken by the person administering the
veterinary
m
edicinal product to
animals
This product can cause skin and eye irritation,
therefore, avoid
contact of the
product with skin and eyes
.
Do not open the pipette near or towards the face. In
case of ocular (eye) exposure or if eyes become irritated during administration,
immediately flush the eyes with plenty of water. If ocular (eye) irritation persists, seek
medical attention. In case of dermal (skin) exposure or if skin becomes irritated
during administration, immediately wash the skin with plenty of soap and water. If
skin irritation persists or recurs, seek medical attention.
People with known hypersensitivity to fipronil and/or permethrin should avoid
contact with the product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke,
drink or eat during
application.
Wash hands after
use. If swallowed rinse mouth
and seek medical attention if you feel unwell.
Since the excipient N-methylpyrrolidone may induce foetotoxicity (toxicity to the
foetus) and teratogenicity (embryonic or foetal malformation) after significant
exposure, pregnant women should wear gloves to avoid contact with the product.
Treated animals should not be handled until the application site is dry,
and
children should not be allowed to play with treated animals until the application site
is dry. It is therefore recommended that animals are not treated during the day, but
should be treated during the early evening,
and
that recently treated animals are
not allowed to sleep with owners,
especially children.
Keep the stored pipettes in the original blister and once used, the empty pipette
should immediately be disposed of appropriately, preventing further access.
Other precaution
The product may adversely affect aquatic organisms. Treated dogs should not be
allowed to enter surface water for 2 days after treatment.
Revised: September 2025
MA split from NI MA following AN: 01659/2025
Do not use simultaneously with other products active against fleas, ticks or flies
which are applied directly on to the animal.
which are applied directly on to the animal.
Store in the original blister.
Do not store above 25°C.
Do not store above 25°C.
Not applicable
5.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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