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AVM-GSL Over the Counter Companion Animal

Fleasolve 402 mg Spot-on Solution for Very Large Dogs

Active ingredient: Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Naqua Ltd

VMD MA No.

49507/5004

What it's used for

Treatment of flea (Ctenocephalides spp.) and tick (Dermacentor reticulatus infestations. Insecticidal efficacy against new infestations with adult fleas pe...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Fleasolve 402 mg Spot-on Solution for Very Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Treatment

of

flea

(Ctenocephalides

spp.)

and

tick

(Dermacentor

reticulatus
infestations.
Insecticidal efficacy against new infestations with adult fleas persists for up to 8
weeks. The product has a persistent acaricidal efficacy for up to 4 weeks
against ticks (Rhipicephalus sanguineus
reticulatusRhipicephalus sanguineus
ricinus
within the first 48 hours but they may be killed within a week.

Revised: October 2025
MA split from NI Expiry following AN: 02208/2025
Route of administration and dosage:
External use only.
Administer by topical application to the skin according to the bodyweight as
follows: 1 pipette of 4.02 ml per dog weighing over 40 kg and up to 60 kg
bodyweight.
For dogs over 60 kg use two pipettes of
2.68 ml. Method of administration:
Thermoformed pipettes:
Hold the pipette upright. Tap the narrow part of the pipette to ensure that the
contents are within the main body of the pipette. Break the snap-off top of the
spot-on pipette along the scored line.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly
against the bared skin and squeeze gently several times to empty its contents
Repeat this procedure at one or two different points along the pet’s back.

Revised: October 2025
MA split from NI Expiry following AN: 02208/2025
(Note: the shape of the marketed pipettes can be different as well as the
pictures on the marketed boxes/package leaflets.)
Polypropylene pipettes:
Remove the pipette from the blister packaging. Hold the pipette in an upright
position, twist and pull the cap off. Turn the cap around and place the other end
of the cap back on the pipette. Twist the cap to break the seal, then remove the
cap from the pipette.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly
against the bared skin and squeeze gently several times to empty its contents.
Repeat this procedure at one or two points along the pet’s back.
It is important to make sure that the product is applied to an area where the
animal cannot lick it off, and to make sure that animals do not lick each other
following treatment.
Care should be taken to avoid excessive wetting of the hair with the product
since this will cause a sticky appearance of hairs at the treatment spot.

Revised: October 2025
MA split from NI Expiry following AN: 02208/2025
However, should this occur, it will disappear within 24 hours post application.
Treatment schedule:
For optimal control of flea and/or tick infestation the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Do not use on puppies less than 2 months old and /or weighing less than 2kg in
the absence of available data.
Do not use on sick (e.g. systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, due to a risk of adverse drug reactions or even death.
This product is specifically developed for dogs. Do not use in cats, as this could
lead to overdosing.
Do not use in known cases of hypersensitivity to the active substance or to any
of excipients.
If licking occurs, a brief period of hypersalivation may be observed due mainly to
the nature of the carrier.
Very rarely transient cutaneous reactions on the application site (skin
discoloration, local alopecia, pruritus, erythema) and general pruritus or alopecia
have been reported after use. Hypersalivation, reversible neurologic symptoms
(hyperesthesia, depression, nervous symptoms), vomiting or respiratory
symptoms have also been observed very rarely after use.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse
reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including
isolated reports).

Revised: October 2025
MA split from NI Expiry following AN: 02208/2025
Shampooing an hour prior to treatment does not affect the efficacy of the
product against fleas.
Bathing/immersion in water within two days after application of the product
should be avoided. Weekly immersion in water for one minute reduces the
period of persistent insecticidal efficacy against fleas by one week.
The product does not prevent ticks from attaching to the animals. If the animal
has been treated prior to exposure to the ticks, the ticks will be killed in the first
24-48 hours after attachment. This will usually be prior to engorgement,
minimising but not excluding the risk of transmission of diseases. Once dead,
ticks will often drop off the animal, but any remaining ticks may be removed with
a gentle pull.
Fleas from pets often infest the animal's basket, bedding and regular resting
areas such as carpets and soft furnishings which should be treated, in case of
massive infestation and at the beginning of the control measures, with a suitable
insecticide and vacuumed regularly.
For optimal control of flea infestation in multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.

Special precautions for use in
animals
Animals should be weighed accurately prior to treatment.
Avoid contact with the animal’s eyes. In the case of accidental eye contact,
immediately rinse the eyes with clean water.
It is important to make sure that the product is applied to an area where the
animal cannot lick it off and to make sure that animals do not lick each other
following treatment.
Do not apply the product on wounds or damaged skin.

Revised: October 2025
MA split from NI Expiry following AN: 02208/2025
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Keep pipettes in original packaging until ready to use
People with a known hypersensitivity to fipronil or excipients (see section 6.1.)
should avoid contact with the veterinary medicinal product.
This product can cause mucous membrane and eye irritation. Therefore, contact
between the product and the mouth or eyes should be avoided.
In the case of accidental eye contact, immediately rinse the eyes with clean
water. If eye irritation persists seek medical advice and show the package leaflet
or the label to the physician.
Avoid contents coming into contact with the skin. If this occurs, wash hands with
soap and water.
Ingestion of the product is harmful. Prevent children getting access to the
pipettes and discard the used pipettes immediately after applying the product.
In case of accidental ingestion of product seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and
children should not be allowed to play with treated animals until the application
site is dry. It is therefore recommended that animals are not treated during the
day, but should be treated during the early evening, and that recently treated
animals should not be allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application. Wash hands after use.
Other precautions
Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to
swim in water courses for 2 days after application.
The product may have adverse effects on painted, varnished or other household
surfaces or furnishings.
None known.
Store below 30°C. Store in a dry place. Store in the original package.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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