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NFA-VPS Over the Counter Companion Animal

Fipronil Spot-on Solution by Virbac 402 mg for Very Large Dogs

Active ingredient: Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Virbac

VMD MA No.

05653/3022

What it's used for

infestations. Insecticidal efficacy against new infestations with adult fleas persists for up to 8 weeks. The veterinary medicinal weeks against ticks (Rhi...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Fipronil

  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Fipronil Spot-on Solution by Virbac 402 mg for Very Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

infestations.
Insecticidal efficacy against new infestations with adult fleas persists for up to 8
weeks.
The veterinary medicinal
weeks against ticks (Rhipicephalus sanguineus, ,
reticulatus). If ticks of some species (Rhipicephalus sanguineus and )
are present when the veterinary medicinal
killed within the first 48 hours but they may be killed within a week.
The veterinary medicinal
control of Flea Allergy Dermatitis (FAD) where this has been previously diagnosed by
a veterinary surgeon.
Administer by topical application to the skin according to the bodyweight as follows :
1 pipette of 4.02 ml per dog weighing over 40 kg and up to 60 kg bodyweight.
For dogs over 60 kg use two pipettes of 2.68 ml.
Method of administration:
Thermoformed pipettes:
Hold the pipette upright. Tap the narrow part of the pipette to ensure that the contents
are within the main body of the pipette. Break the snap-off top of the spot-on pipette
along the scored line.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents Repeat this
procedure at one or two different points along the pet’s back.
(Note : the shape of the marketed pipettes can be different as well as the pictures on
the marketed boxes/package leaflets.)
Polypropylene pipettes:
Remove the pipette from the blister packaging. Hold the pipette in an upright position,
twist and pull the cap off. Turn the cap around and place the other end of the cap
back on the pipette. Twist the cap to break the seal, then remove the cap from the
pipette.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents. Repeat this
procedure at one or two points along the pet’s back.
It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off, and to make sure that animals do not lick each
other following treatment.
Care should be taken to avoid excessive wetting of the hair with the veterinary
medicinal product since this will cause a sticky appearance of hairs at the treatment
spot. However, should this occur, it will disappear within 24 hours post application.
Treatment schedule:
For optimal control of flea and/or tick infestation the treatment schedule can be based
on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Do not use on puppies less than 2 months old and /or weighing less than 2kg in the
absence of available data.
Do not use on sick (e.g. systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, as adverse reactions and even death could occur.
This veterinary medicinal
cats, as this could lead to overdosing.
Do not use in cases of hypersensitivity to the active substance or to any of excipients.
Dogs
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site reaction
(e.g. skin hair
coat, discolouration, alopecia, pruritus,
erythema)
Generalised itching, Alopecia general
Hypersalivation
Neurological disorder
(e.g. Hyperesthesia,
central nervous system depression and
neurological symptoms)

Vomiting
Respiratory tract disorders
Transient cutaneous reactions on the application site.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Reversible symptoms.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the
national competent authority via the national reporting system. See the package
leaflet for respective contact details.
Shampooing an hour prior to treatment does not affect the efficacy of the veterinary
medicinal product against fleas.
Bathing/immersion in water within two days after application of the veterinary
medicinal product should be avoided.
reduces the period of persistent insecticidal efficacy against fleas by one week and
therefore it is advisable to avoid frequent swimming and shampooing.
The veterinary medicinal
animals. If the animal has been treated prior to exposure to the ticks, the ticks will be
killed in the first 24-48 hours after attachment. This will usually be prior to
engorgement, minimising but not excluding the risk of transmission of diseases.
Once dead, ticks will often drop off the animal, but any remaining ticks may be
removed with a gentle pull.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
When used as part of a strategy for the treatment of Flea Allergy Dermatitis, monthly
applications to the allergic patient and to other dogs in the household are
recommended.
For optimal control of flea infestation in multi-pet household, all dogs and cats in the
household should be treated with a suitable insecticide.

Special precautions for safe use in the target species:
Animals should be weighed accurately prior to treatment.
Avoid contact with the animal’s eyes. In the case of accidental eye contact,
immediately and thoroughly flush the eyes with water.
It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off and to make sure that animals do not lick each
other following treatment
Do not apply the product on wounds or damaged skin.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane and eye irritation.
Therefore, contact between the veterinary medicinal product and the mouth or eyes
should be avoided.
In the case of accidental eye contact, immediately and thoroughly flush the eyes with
water. If eye irritation persists seek medical advice and show the package leaflet or
the label to the physician.
Do not smoke, drink or eat during application.
Avoid contents coming into contact with the fingers. If this occurs, wash hands with
soap and water. Wash hands after use.
People with known hypersensitivity to fipronil or excipients should avoid contact with
the veterinary medicinal product.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals should not be
allowed to sleep with owners, especially children.
Special precautions for the protection of the environment:
Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim
in water courses for 2 days after application.
Other precautions:
The veterinary medicinal product may have adverse effects on painted, varnished or
other household surfaces or furnishings.
None known.
Store below 30°C.
Store in a dry place.
Store in the original package.
Do not remove from blister until required for use.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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