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NFA-VPS Over the Counter Companion Animal

Fiprex L 300 mg Spot-on Solution for Dogs

Active ingredient: Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Vet-Agro Trading Sp. Z o.o.

VMD MA No.

41715/5000

What it's used for

For the treatment of fleas (Ctenocephalides felis) and ticks (Rhipicephalus sanguineus, Dermacentor reticulatus) infestations. The product shows immediate...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Fiprex L 300 mg Spot-on Solution for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of fleas (Ctenocephalides felis) and ticks (Rhipicephalus
sanguineus, Dermacentor reticulatus) infestations.
The product shows immediate insecticidal effect and persistent insecticidal activity
against new infestations by adult fleas for up to 8 weeks.
The product has a persistent acaricidal efficacy against Rhipicephalus sanguineus
and Dermacentor reticulatus for up to 4 weeks. If ticks of these species are present
when the product is applied, all ticks will not be killed within the first 48 hours but they
may be killed within a week.
The product can be used as part of a treatment strategy for the control of Flea Allergy
Dermatitis (FAD) where this has been previously diagnosed by a veterinary surgeon.
Application:
Application– spot-on use.
One pipette (4 ml) containing 300 mg of fipronil per dog weighing 20-40 kg.
Animals should be weighed prior to treatment.
Method of administration:
Open the pipette by tearing off the tip. Part the fur between the shoulder blades and
apply the pipette content onto the animal’s skin.
If necessary, administer the product to more than one spot between the shoulder
blades to minimise the chances of run-off and to ensure the whole dose is
administered.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
The current epidemiological situation in the area concerned should always be taken
into account.
Following the manufacturer’s instructions and warnings will reduce to a minimum the
possibility of occurrence of adverse reactions.

Revised: December 2025
MA Split due to AN: 01237/2025
It is important to make sure that the product is applied to an area where the animal
cannot lick it off, and to make sure that animals do not lick each other following
treatment.
Care should be taken to avoid excessive wetting of the hair with the product since
this will cause a sticky appearance of hairs at the treatment spot. However, should
this occur, it will disappear within 24 hours post application.
The product should not be used on puppies less than 2 months old and/or weighing
less than 20 kg.
Do not use on sick (systemic disease, fever etc.) or convalescent animals.
Do not use in rabbits, as adverse drug reactions and even death could occur.
This veterinary medicinal product has been developed specifically for dogs. Do not
use on cats as this could lead to overdosing.
Do not use on animals with hypersensitivity to active substance or any other
excipients.
Do not apply on damaged skin of the animal.

Revised: December 2025
MA Split due to AN: 01237/2025
If the animal licks the application site, hypersalivation, vomiting, or neurological
symptoms (hypersensitivity or lethargy) may occur.
Hair coat discolouration, local hair loss, irritation, itching or oily appearance may
occur at the application site.
Prevent the animals from licking the site of application a few hours after treatment.
All cats and dogs in the household should undergo the treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in dogs
are available. Therefore, bathing/immersion in water within 2 days of application and
more frequent bathing than once a week should be avoided.
There may be an attachment of some ticks but ticks will be killed in the first 24-48
hours after attachment. This will be usually prior to full engorgement and therefore
minimising but not excluding the risk of transmission of diseases.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
When used as part of a strategy for the treatment of flea Allergy Dermatitis, monthly
applications to the allergic patient and to other dogs in the household are
recommended.
For optimal control of flea infestation in multi-pet household, all dogs and cats in the
household should be treated with a suitable insecticide.

Special precautions for use in animals
For external use only.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off. Do not allow recently treated animals to lick each other.
Avoid contact with the animal's eyes. Should the veterinary medicinal product come
into contact with the eyes, rinse thoroughly at once with water.
Animals should be weighed accurately prior to treatment.
Do not apply the product on wounds or damaged skin.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Keep pipettes in original packaging until ready to use.
People with a known hypersensitivity to fipronil or excipients (see section 6.1.) should
avoid contact with the veterinary medicinal product.
Avoid contents coming into contact with the skin. If this occurs, wash hands with soap
and water. This product can cause mucous membrane and eye irritation. Contact of
the product with mouth and eyes should be avoided. In the case of accidental eye
contact, immediately and thoroughly rinse the eyes carefully with plain water. If eye
irritation persists seek medical advice and show the package leaflet or the label to the
physician.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product. In case of
accidental ingestion of product seek medical advice immediately.
Avoid contact with treated animals until the application site is dry. Children should not
be allowed to play with treated animals until the application site is dry. It is therefore
recommended that animals are not treated during the day, but should be treated

Revised: December 2025
MA Split due to AN: 01237/2025
during the early evening, and that recently treated animals should not be allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Wash hands after use.
Other precautions
Product may adversely affect aquatic organisms. Dogs should not be allowed to swim
in watercourses for 2 days after application (See section 6.6).
The product may have adverse effects on painted, varnished or other household
surfaces or furnishing.
No data available.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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