Excenel Flow, 50 mg/ml, Suspension for Injection for Pigs and Cattle
Active ingredient: Ceftiofur
Form
Injection
Species
Manufacturer
Zoetis Belgium S.A.
VMD MA No.
60021/3075
What it's used for
In cattle: For the treatment of bacterial respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni For the t...
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Prescription required
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Excenel Flow, 50 mg/ml, Suspension for Injection for Pigs and Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
For the treatment of bacterial respiratory disease associated with Mannheimia
haemolytica, Pasteurella multocida and Histophilus somni
For the treatment of acute interdigital necrobacillosis (panaritium, foot rot), associated with
Fusobacterium necrophorum and Prevotella melaninogenica.
For treatment of the bacterial component of acute post-partum (puerperal) metritis within
10 days after calving associated with Escherichia coli, Trueperella pyogenes and
Fusobacterium necrophorum, sensitive to ceftiofur, where treatment with another
antimicrobial has failed.
Pigs:
3 mg ceftiofur/kg bw/day for 3 days via intramuscular route, i.e. 1 ml/16 kg bw/day.
Not more than 4 ml should be administered per injection site.
Cattle:
Respiratory disease: 1 mg ceftiofur/kg bw/day for 3 to 5 days by subcutaneous injection,
i.e. 1 ml/50 kg bw/day.
Acute interdigital necrobacillosis: 1 mg ceftiofur/kg bw/day for 3 days by subcutaneous
injection, i.e. 1 ml/50 kg bw/day.
Acute post-partum metritis within 10 days after calving: 1 mg ceftiofur/kg bw/day for 5
consecutive days by subcutaneous injection, i.e. 1 ml/50 kg bw/day.
Not more than 13 ml should be administered per injection site.
In case of acute post-partum metritis, additional supportive therapy might be required in
some cases.
Subsequent injections must be given at different sites.
50 ml and 100 ml vials can be broached a maximum of 50 times. 250 ml vials can be
broached a maximum of 33 times. Otherwise, the use of a multiple-dose syringe is
recommended.
antibiotics or to any of the excipients.
Do not inject intravenously.
Do not use in cases where resistance to other cephalosporins or beta-lactam antibiotics
has occurred.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial resistance to
humans.
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reaction (e.g. allergic skin
reaction, anaphylaxis), Injection site
reaction (e.g. discolouration of fascia or
fat)
1
Mild, observed for up to 20 days.
Cattle:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reaction (e.g. allergic skin
reaction, anaphylaxis), Injection site
induration, Injection site swelling, Injection
site inflammation
1
Mild to moderate, observed until 42 days post injection.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Special precautions for safe use in the target species:
In case of the occurrence of allergic reaction the treatment should be withdrawn.
The veterinary medicinal product selects for resistant strains such as bacteria carrying
extended spectrum betalactamases (ESBL) which may constitute a risk to human health if
these strains disseminate to humans e.g. via food. For this reason, the veterinary
medicinal product should be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly (refers to very acute cases when
treatment must be initiated without bacteriological diagnosis), to more narrow spectrum
antimicrobials first line treatment. Official, national and regional antimicrobial policies
should be taken into account when the veterinary medicinal product is used. Increased
use, including use of the veterinary medicinal product deviating from the instructions given
in the SPC, may increase the prevalence of such resistance bacteria resistant to the
veterinary medicinal product. Whenever possible, the veterinary medicinal product should
only be used based on susceptibility testing.
Do not use as prophylaxis in case of retained placenta.
The veterinary medicinal product is intended for treatment of individual animals. Do not
use for disease prevention or as a part of herd health programmes. Treatment of groups of
animals should be strictly limited to ongoing disease outbreaks according to the approved
conditions of use.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
People with known hypersensitivity to cephalosporins and penicillins should avoid contact
with the veterinary medicinal product.
If you develop symptoms following exposure such as a skin rash, seek medical advice
immediately and show the package leaflet or the label to the physician.
Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms
and require urgent medical attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
bacteriostatic antibiotics (macrolides, sulfonamides and tetracyclines).
Aminoglycosides may have a potentiating effect on cephalosporins.
Meat and offal: 2 days.
Cattle:
Meat and offal: 6 days; milk: zero hours.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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