Cefavex 50 mg/ml Suspension for Injection for Pigs and Cattle
Active ingredient: Ceftiofur
Form
Injection
Species
Manufacturer
SP Veterinaria, S.A.
VMD MA No.
36967/4002
What it's used for
In cattle: For the treatment of bacterial respiratory disease associated with (previously ), (previously haemolytica) and Pasteurella multocida. For the tr...
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Prescription required
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Cefavex 50 mg/ml Suspension for Injection for Pigs and Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
For the treatment of bacterial respiratory disease associated with
(previously ), (previously
haemolytica) and Pasteurella multocida.
For the treatment of acute interdigital necrobacillosis (panaritium, foot rot),
AN: 01173/2024 & 01175/2024
associated with Porphyromonas asaccharolytica) and
Fusobacterium necrophorum.
For treatment of the bacterial component of acute post-partum (puerperal) metritis
within 10 days after calving associated with
coli, sensitive to ceftiofur. The indication is
restricted to cases where treatment with another antimicrobial has failed.
Cattle:
Respiratory disease: 1 mg ceftiofur /kg bw/day for 3 to 5 days by subcutaneous
injection, i.e. 1 ml/50 kg bw at each injection.
Acute interdigital necrobacillosis: 1 mg/kg bw/day for 3 days by subcutaneous
injection, i.e. 1 ml/50 kg bw at each injection.
Acute post-partum metritis within 10 days after calving: 1 mg/kg bw/day for 5
consecutive days by subcutaneous injection, i.e. 1 ml/50 kg bw at each injection.
Before use, shake the bottle vigorously for at least 30 seconds until the veterinary
medicinal product appears adequately resuspended. Following shaking the bottle
should be visually examined to ensure that the veterinary medicinal product is
brought back into suspension. The absence of settled material can be confirmed by
inverting the vial and viewing the contents through the base of the vial.
AN: 01173/2024 & 01175/2024
The recommended maximum volume to be administered at a single injection site is 4
ml in pigs and 6 ml in cattle. Subsequent injections must be given at different sites.
The vial cannot be broached more than 66 times.
In case of acute post-partum metritis, additional supportive therapy might be required
in some cases.
any of the excipient(s).
Do not inject intravenously.
Do not use in cases where resistance to other cephalosporins or beta-lactam
antibiotics has occurred.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial resistance
to humans.
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reactions
Allergic reactions (e.g. skin
reactions, anaphylaxia)
1
Unrelated to dose.
In this case, the treatment should be withdrawn.
Pigs:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site reactions (e.g. discoloration
of the fascia or fat)
1
Mild reactions, discoloration can persist in some animals for up to 20 days after
injection.
AN: 01173/2024 & 01175/2024
Cattle:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site reactions (e.g. as tissue
oedema, discoloration
)
1
Subcutaneous tissue and/or fascial surface of the muscle.
Mild inflammatory reactions, clinical resolution is reached in most animals by 10
days after injection
although slight tissue discoloration may persist for 28 days or more.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Special precautions for use in the target species:
This veterinary medicinal product does not contain any antimicrobial preservative.
The veterinary medicinal product selects for resistant strains such as bacteria
carrying extended spectrum betalactamases (ESBL) and may constitute a risk to
human health if these strains disseminate to humans e.g. via food. For this reason,
the veterinary medicinal product should be reserved for the treatment of clinical
conditions which have responded poorly, or are expected to respond poorly (refers to
very acute cases when treatment must be initiated without
bacteriological diagnosis) to first line treatment. Official, national and regional
antimicrobial policies should be taken into account when the veterinary medicinal
product is used. Increased use, including use of the veterinary medicinal product
deviating from the instructions given in the SPC, may increase the prevalence of
such resistance.
Whenever possible, the veterinary medicinal product should only be used based on
susceptibility testing.
The veterinary medicinal product is intended for treatment of individual animals. Do
not use for disease prevention or as a part of herd health programmes. Treatment of
groups of animals should be strictly restricted to ongoing disease outbreaks
according to the approved conditions of use.
AN: 01173/2024 & 01175/2024
Do not use as prophylaxis in case of retained placenta.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead
to cross reactions to cephalosporins and vice versa. Allergic reactions to these
substances may occasionally be serious.
People with known hypersensitivity to ceftiofur should avoid contact with the
veterinary medicinal product. Do not handle this product if you know you are
sensitised, or if you have been advised not to work with such preparations.
Handle this veterinary medicinal product with great care to avoid exposure. Wash
hands after use.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning.
Swelling of the face, lips or eyes or difficulty with breathing are more serious
symptoms and require urgent medical attention.
Special precautions for the protection of the environment:
Not applicable.
bacteriostatic antibiotics (macrolides, sulphonamides and tetracyclines).
Keep the vial in the outer carton in order to protect from light.
Meat and offal: 5 days.
Cattle:
Meat and offal: 8 days.
Milk: zero hours.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
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These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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