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Cevaxel-RTU 50 mg/ml, Suspension for Injection for Cattle and Pigs

Active ingredient: Ceftiofur

Form

Injection

Species

Cattle Pigs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/3057

View official SPC (PDF)

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Clinical information

Cevaxel-RTU 50 mg/ml, Suspension for Injection for Cattle and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

In Cattle:
For the treatment of bacterial respiratory disease associated with ,
Mannheimia haemolytica and Pasteurella multocida
For the treatment of acute interdigital necrobacillosis (panaritium, foot rot), associated
with and (Porphyromonas
asaccharolytica
For treatment of the bacterial component of acute post-partum (puerperal) metritis within
10 days after calving associated with , and
Fusobacterium necrophorum: : this indication is restricted to cases where treatment with
another antimicrobial has failed.
In Pigs:
For the treatment of bacterial respiratory disease associated with ,
Actinobacillus pleuropneumoniae and .
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kg at each injection.
- Acute interdigital necrobacillosis: 1 mg ceftiofur (as hydrochloride)/kg /day for 3 days, i.e.
1 ml/50 kg at each injection.
- Acute post-partum metritis within 10 days after calving:
1 mg ceftiofur (as hydrochloride)/kg /day for 5 consecutive days, i.e. 1 ml/50 kg at each
injection.
In case of acute post-partum metritis, additional supportive therapy might be required in
some cases.
Pigs:
3 mg ceftiofur (as hydrochloride)/kg /day for 3 days, i.e. 1 ml/16 kg at each injection.
Shake the bottle well before use to bring the product back into suspension.
To ensure a correct dosage, body weight should be determined as accurately as possible.
Subsequent injections must be given at different sites.
As the vial cannot be broached more than 50 times, the user should choose the more
appropriate vial size.

Do not administer to an animal previously found to be hypersensitive to ceftiofur and other
β-lactam
Do not inject intravenously.
Do not use where resistance to other cephalosporins or beta-lactam antibiotics has
occurred.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial resistance to
humans.

Cattle:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction
, Allergic skin reaction
,
Anaphylaxis
Rare
(1 to 10 animals / 10,000 animals
treated):
Injection site reaction
(e.g. inflammation, oedema,
thickening
, discoloration
)
In case of the occurrence of allergic reaction the treatment should be withdrawn.
Clinical resolution is reached in most animals by 10 days after injection although slight
tissue discoloration may persist for 28 days or more.
Of connective tissue
Of the subcutaneous tissue and/or fascial surface of the muscle
Pigs
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction
, Allergic skin reaction
,
Anaphylaxis
Undetermined frequency
(cannot be estimated from the
available data)
Injection site reaction (e.g. discoloration)
1
In case of the occurrence of allergic reaction the treatment should be withdrawn.
Of the fascia or fat, mild, observed in some animals for up to 20 days after injection.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

None known.

Special precautions for safe use in the target species:
Do not use as prophylaxis in case of retained placenta.
This veterinary medicinal product selects for resistant strains such as bacteria carrying
extended spectrum betalactamases (ESBL) and may constitute a risk to human health if
these strains disseminate to humans e.g. via food. For this reason, this product should be
reserved for the treatment of clinical conditions which have responded poorly, or are
expected to respond poorly (refers to very acute cases when treatment must be initiated
without bacteriological diagnosis) to first line treatment. Official, national and regional
antimicrobial policies should be taken into account when the product is used. Increased
use, including use of the product deviating from the instructions given in the SPC, may
increase the prevalence of such resistance. Whenever possible, this product should only
be used based on susceptibility testing.
This veterinary medicinal product is intended for treatment of individual animals. Do not
use for disease prevention or as a part of heard health programs. Treatment of groups of
animals should be strictly restricted to ongoing disease outbreaks according to the
approved conditions of use.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
- Do not handle this veterinary medicinal product if you know you are sensitised or if you
have been advised not to work with such preparations.
- Handle this veterinary medicinal product with great care to avoid exposure. Wash hands
after use.
- If you develop symptoms following exposure, such as a skin rash, you should
seek medical advice and show the doctor this warning.
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Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms
and require urgent medical attention.
Special precautions for the protection of the environment:
Not applicable.

The bactericidal properties of cephalosporins are antagonized by simultaneous use of
bacteriostatic antibiotics (macrolides, sulfonamides and tetracyclines).
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Keep the vial in the outer carton in order to protect from light.

Cattle:
Meat and offal: 8 days.
Milk: zero hours.
Pigs:
Meat and offal: 5 days.
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This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.