Ceftiosan, 50 mg/ml, Suspension for Injection for Pigs and Cattle
Active ingredient: Ceftiofur
Form
Injection
Species
Manufacturer
Alfasan Nederland B.V.
VMD MA No.
36408/4000
What it's used for
Infections associated with bacteria sensitive to ceftiofur: In pigs: -Treatment of bacterial respiratory disease associated with Pasteurella multocida, Act...
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Prescription required
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Ceftiosan, 50 mg/ml, Suspension for Injection for Pigs and Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
In pigs:
-Treatment of bacterial respiratory disease associated with Pasteurella multocida,
Actinobacillus pleuropneumoniae and .
This product is not to be used in pigs with a bodyweight more than 125 kg.
In cattle:
-Treatment of bacterial respiratory disease associated with Mannheimia haemolytica,
Pasteurella multocida Histophilus somni (previously Haemophilus somnus).
-Treatment of acute interdigital necrobacillosis (panaritium, foul in the foot), associated
with Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas
asaccharolytica).
-Treatment of the bacterial component of acute post-partum (puerperal) metritis within 10
days after calving associated with and
Fusobacterium necrophorum, sensitive to ceftiofur. The indication is restricted to cases
where treatment with another antimicrobial has failed.
Bacterial respiratory disease: 3 mg ceftiofur /kg bw/day for 3 days via intramuscular
route, i.e. 1 ml/16 kg bw at each injection.
The maximum injection volume must not exceed 4 ml per injection site. Each injection
must be given at separate sites, with no overlap of subsequent injections. This product is
not to be used in pigs with a bodyweight more than 125 kg.
Cattle:
Bacterial respiratory disease: 1 mg ceftiofur /kg bw/day for 3 to 5 days by subcutaneous
injection, i.e. 1 ml/50 kg bw at each injection.
Acute interdigital necrobacillosis: 1 mg/kg bw/day for 3 days by subcutaneous injection,
i.e. 1 ml/50 kg bw at each injection.
Acute post-partum metritis within 10 days after calving: 1 mg/kg bw/day for 5 consecutive
days by subcutaneous injection, i.e. 1 ml/50 kg bw at each injection.
In case of acute post-partum metritis, additional supportive therapy might be required in
some cases.
Each injection must be given at separate sites, with no overlap of subsequent injections.
To ensure a correct dosage body weight should be determined as accurately as possible
to avoid underdosing.
Revised: March 2017
AN: 01508//2016
Before use shake the bottle for 15 seconds or until the product appears adequately
resuspended.
As the vial cannot be broached more than 40 times, the user should choose the most
appropriate vial size.
Revised: March 2017
AN: 01508//2016
Do not administer to an animal previously found to be hypersensitive to ceftiofur and
other -lactam antibiotics or to any of the excipients.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial resistance to
humans.
reactions, anaphylaxia) may occasionally occur. In case of the occurrence of allergic
reaction the treatment should be withdrawn.
In pigs, mild reactions at the injection site, such as discoloration of the fascia or fat, have
been observed in some animals for up to 20 days after injection.
In cattle, mild inflammatory reactions at the injection site, such as tissue oedema and
discoloration of the subcutaneous tissue and/or fascial surface of the muscle may be
observed. Clinical resolution is reached in most animals by 10 days after injection
although slight tissue discoloration may persist for 28 days or more.
Cross resistance to other lactam antibiotics can be present. Do not use in cases such
cross-resistance is known.
Shake the bottle well before use to bring the product back into suspension.
Special precautions for use in animals
In case of the occurrence of allergic reaction the treatment should be withdrawn.
This product selects for resistant strains such as bacteria carrying extended spectrum
betalactamases (ESBL) and may constitute a risk to human health if these strains
disseminate to humans e.g. via food. For this reason, this product should be reserved for
the treatment of clinical conditions which have responded poorly, or are expected to
respond poorly (refers to very acute cases when treatment must be initiated without
bacteriological diagnosis) to first line treatment. Official, national and regional
antimicrobial policies should be taken into account when the product is used. Increased
use, including use of the product deviating from the instructions given in the SPC, may
increase the prevalence of such resistance.
Whenever possible, this product should only be used based on susceptibility testing.
This product is intended for treatment of individual animals. Do not use for disease
prevention or as a part of herd health programmes. Treatment of groups of animals
should be strictly restricted to ongoing disease outbreaks according to the approved
conditions of use.
Do not use as prophylaxis in case of retained placenta.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been advised
not to work with such preparations. Handle this product with great care to avoid
exposure, taking all recommended precautions.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes or
difficulty with breathing, are more serious symptoms and require urgent medical
attention.
Revised: March 2017
AN: 01508//2016
Wash hands after use.
bacteriostatic antibiotics (macrolides, sulfonamides and tetracyclines).
Meat and offal: 8 days.
Cattle:
Meat and offal: 8 days.
Milk: zero hours.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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