Eraquell 18.7 mg/g Oral Paste

Strategies that should be avoided because they might lead to an increased risk of
development of resistance to anthelmintic drugs include:
• Too frequent and repeated use of anthelmintics from the same class over an
extended period of time.
• Underdosing, which may be due to underestimation of body weight,
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests. Where the results of the test(s) strongly
suggest resistance to a particular anthelmintic, an anthelmintic belonging to another
pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in Parascaris equorum in horses.
Therefore the use of this product should be based on local (regional, farm)
epidemiological information about susceptibility of nematodes and
recommendations on how to limit further selection for resistance to anthelmintics.

Revised: October 2024
MA split from NI MA following AN: 03943/2022

i. Special precautions for use in animals
Avermectins may not be well tolerated in all non-target species (cases of
intolerance with fatal outcome are reported in dogs, especially Collies, Old
English Sheepdogs and related breeds or crosses, and also in
turtles/tortoises).
As ivermectin is extremely dangerous to fish and aquatic life treated animals
should not have direct access to surface water and ditches during treatment.
Parasite resistance to any particular class of anthelmintic may develop
following frequent, repeated use of an anthelmintic of that class.
Since ivermectin is highly bound to plasma proteins, special care should be
taken in cases of sick animals or in nutritional conditions associated with low
plasma protein levels.
As with all anthelmintics, a veterinary surgeon should establish appropriate
dosing programs and stock management to achieve adequate parasite control
and reduce the likelihood of anthelmintic resistance.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Do not eat, drink or smoke while handling the product. Avoid contact with skin
and eyes. If accidental skin contact occurs, wash the affected area
immediately with soap and water. If accidental eye exposure occurs, flush the
eyes immediately with water and, if necessary, get medical attention.
Wash hands after use.