Eraquell 18.7 mg/g Oral Paste

Strategies that should be avoided because they might lead to an increased risk of
development of resistance to anthelmintic drugs include:
• Too frequent and repeated use of anthelmintics from the same class over an extended
period of time.
• Underdosing, which may be due to underestimation of body weight, misadministration of
the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using
appropriate tests. Where the results of the test(s) strongly suggest resistance to a
particular anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to ivermectin has been reported in Parascaris equorum in horses. Therefore
the use of this veterinary medicinal product should be based on local (regional, farm)
epidemiological information about susceptibility of nematodes and recommendations on
how to limit further selection for resistance to anthelmintics.

Special precautions for safe use in the target species:
Parasite resistance to any particular class of anthelmintic may develop following frequent,
repeated use of an anthelmintic of that class.
Since ivermectin is highly bound to plasma proteins, special care should be taken in cases
of sick animals or in nutritional conditions associated with low plasma protein levels.
As with all anthelmintics, a veterinary surgeon should establish appropriate dosing
programs and stock management to achieve adequate parasite control and reduce the
likelihood of anthelmintic resistance.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Do not eat, drink or smoke while handling the product. Avoid contact with skin and eyes. If
accidental skin contact occurs, wash the affected area immediately with soap and water. If
accidental eye exposure occurs, flush the eyes immediately with water and, if necessary,
get medical attention.
Wash hands after use.
Special precautions for the protection of the environment:
As ivermectin is extremely dangerous to fish and aquatic life treated animals should not
have direct access to surface water and ditches during treatment.
Other precautions:
Avermectins may not be well tolerated in all non-target species (cases of intolerance with
fatal outcome are reported in dogs, especially Collies, Old English Sheepdogs and related
breeds or crosses, and also in turtles/tortoises).