Eficur 50 mg/ml Suspension for Injection for Pigs and Cattle
Active ingredient: Ceftiofur
Form
Injection
Species
Manufacturer
Laboratorios Hipra SA
VMD MA No.
17533/3009
What it's used for
Cattle: - For the treatment of bacterial respiratory disease associated with somni, Mannheimia haemolytica and Pasteurella multocida. - For the treatment o...
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Prescription required
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Eficur 50 mg/ml Suspension for Injection for Pigs and Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
- For the treatment of bacterial respiratory disease associated with
somni, Mannheimia haemolytica and Pasteurella multocida.
- For the treatment of acute interdigital necrobacillosis (panaritium, foot rot)
associated with
Fusobacterium necrophorum.
- For the treatment of the bacterial component of acute post-partum (puerperal)
metritis within 10 days after calving associated with Arcanobacterium pyogenes,
Escherichia coli and Fusobacterium necrophorum
treatment with another antimicrobial has failed).
Pigs:
3 mg ceftiofur/kg bw/day for 3 days by intramuscular injection, i.e. 1 ml of the product
/16 kg bw/day.
Cattle:
Treatment of respiratory disease: 1 mg ceftiofur/kg bw/day for 3 to 5 days by
subcutaneous injection, i.e. 1 ml of the product /50 kg bw/day.
Treatment of acute interdigital necrobacillosis: 1 mg ceftiofur/kg bw/day for 3 days by
subcutaneous injection, i.e. 1 ml of the product/50 kg bw/day.
Acute post-partum metritis within 10 days after calving: 1 mg ceftiofur/kg bw/day for
5 consecutive days by subcutaneous injection, i.e. 1 ml of the product /50 kg bw/day.
Subsequent injections must be given at different sites.
In case of acute post-partum metritis, additional supportive therapy might be required
in some cases.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Shake well before use.
antibiotics.
Do not inject intravenously.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial
resistance to humans.
Very rare
(<1 animals / 10 000 animals
treated):
Injection site reaction
(e.g. oedema,
discoloration
)
Hypersensitivity reaction
, allergic reaction (e.g.
allergic skin reaction, anaphylaxis)
Mild inflammatory reactions. Clinical resolution is reached in most animals by 10
days after injection although slight tissue discoloration may persist for 28 days or
more.
Of the subcutaneous tissue and/or fascial surface of the muscle.
Unrelated to dose.
Pigs:
Very rare
(<1 animals / 10 000 animals
treated):
Injection site reaction
(e.g. discoloration
)
Hypersensitivity reaction
, allergic reaction (e.g.
allergic skin reaction, anaphylaxis)
Mild reactions, up to 20 days after injection.
Of the fascia or fat.
Unrelated to dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Special precautions for safe use in the target species:
In case of the occurrence of allergic reaction the treatment should be withdrawn.
Ceftiofur selects for resistant strains such as bacteria carrying extended-spectrum
beta-lactamases (ESBL) and may constitute a risk to human health if these strains
disseminate to humans e.g. via food. Ceftiofur should be reserved for the treatment
of clinical conditions which have responded poorly, or are expected to respond
poorly (refers to very acute cases when treatment must be initiated without
bacteriological diagnosis) to first line treatment.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
Increased use, including use of the product deviating from the instructions given in
the SPC, may increase the prevalence of such resistance. Whenever possible,
ceftiofur should only be based on susceptibility testing.
Ceftiofur should only be used in individual animals.
Do not use for disease prevention or as a part of herd health programmes.
Treatment of groups of animals should be strictly restricted to ongoing disease
outbreaks according to the approved conditions of use (see section 3.2 Indications
for use, specifying the target species).
Do not use as prophylaxis in case of retained placenta.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead
to cross reactions to cephalosporins and vice versa. Allergic reactions to these
substances may occasionally be serious.
People with known hypersensitivity to penicillins or cephalosporins should avoid
contact with the product.
In the case of accidental self-injection or following exposure, if you develop
symptoms such as a skin rash, seek medical advice immediately and show the
package leaflet or the label to the physician.
Swelling of the face, lips or eyes or difficulty with breathing are more serious
symptoms and require urgent medical attention.
Special precautions for the protection of the environment:
Not applicable.
bacteriostatic antibiotics (macrolides, sulphonamides and tetracyclines).
Do not store above 25 ºC.
No breakpoints have been determined to date for the pathogens associated
with foot rot or acute post-partum metritis in cows.
Do not refrigerate or freeze.
PET bottles
Keep the PET bottles in the outer carton in order to protect from light.
Meat and offal: 5 days.
Cattle:
Meat and offal: 8 days.
Milk: zero days.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
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