Effipro Duo 100 mg/120 mg Spot-on Solution for Very Large Cats

Wetting of the haircoat with water 2 hours before veterinary medicinal product
application and twice during the claimed period of efficacy against fleas (at two week
intervals against adult fleas or four week intervals against developing flea stages) was
investigated during two laboratory studies. Wetting of the haircoat with water as
described did not adversely affect veterinary medicinal product effectiveness.
The impact of shampooing on veterinary medicinal product effectiveness has not been
investigated. If a cat requires shampooing it is recommended that this is done before
applying the veterinary medicinal product.
At the beginning of the control measures, in the case of an infestation, the animal's
basket, bedding and regular resting areas such as carpets and soft furnishings should
be treated, with a suitable insecticide and vacuumed regularly.
To reduce environmental flea challenge, all animals living in the same household
should also be treated with a suitable flea control veterinary medicinal product.
The veterinary medicinal product does not prevent ticks from attaching to animals. If
the animal has been treated prior to exposure to the ticks, the ticks will be killed within
48 hours after attachment. This will usually be prior to engorgement, minimising but
not excluding the risk of transmission of diseases.
Once dead, ticks will often drop off the animal. Any remaining ticks should be carefully
removed, ensuring that their mouth parts are not left within the skin.

Special precautions for safe use in the target species:
For external use only. Do not administer orally.
Animals should be weighed accurately prior to treatment.
The safety of the veterinary medicinal product has not been established in cats
younger than 10 weeks of age or in cats weighing less than 1.0 kg.
Avoid contact with the animal’s eyes. In the case of accidental eye contact, flush the
eyes with water.
Care should be taken to apply the veterinary medicinal product correctly as
described under section 3.9. Do not apply the veterinary medicinal product on
wounds or damaged skin. It is important to make sure that the veterinary medicinal
product is applied directly onto an area of dry skin where the animal cannot lick it off
and to make sure that animals do not lick each other following treatment.
The use of the veterinary medicinal product has not been studied in sick or debilitated
cats.
Consult your veterinary surgeon before using the veterinary medicinal product if your
cat is unwell or currently receiving any other veterinary treatment.
Inform your veterinary surgeon that you are using this veterinary medicinal product if
s/he provides your cat with any other medication.
Seek veterinary advice if the veterinary medicinal product is accidentally ingested or
comes into contact with your animal’s eyes.
In the absence of additional safety studies, do not repeat the treatment at intervals of
less than 4 weeks.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
The veterinary medicinal product may cause neurotoxicity.
The veterinary medicinal product may be harmful if swallowed.
Avoid ingestion including hand-to-mouth contact.
Do not smoke, drink or eat during application.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
This veterinary medicinal product can cause eye and mucous membrane irritation.
Avoid contact with skin, eye and mouth, including hand to eye contact.
In the case of accidental skin or eye contact, immediately and thoroughly flush with
water. If skin or eye irritation persists, seek medical advice and show the package
leaflet or the label to the physician.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals should not be
allowed to sleep with owners, especially children.
Keep the pipettes in the original packaging until ready for use and dispose of used
pipettes immediately.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The veterinary medicinal product may have adverse effects on painted, varnished or
other household surfaces or furnishings. Allow the application site to dry before
permitting contact with such materials.