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AVM-GSL Over the Counter Companion Animal

Effipro 50 mg Spot-on Solution for Cats

Active ingredient: Fipronil

Form

Spot-on

Species

Cats

Manufacturer

VIRBAC

VMD MA No.

05653/3056

What it's used for

infestations. The veterinary medicinal product has a persistent insecticidal efficacy for up to 5 weeks against fleas (Ctenocephalides ). The veterinary me...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Effipro 50 mg Spot-on Solution for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

infestations.
The veterinary medicinal product has a persistent insecticidal efficacy for up to 5
weeks against fleas (Ctenocephalides ).
The veterinary medicinal product has a persistent acaricidal efficacy for up to 2
weeks against ticks (Rhipicephalus sanguineus, Ixodes ricinus,
reticulatus). If ticks of some species (Rhipicephalus sanguineus and )
are present when the product is applied, all the ticks may not be killed within the first
48 hours but they may be killed within a week.
Administer by topical application to the skin 1 pipette of 0.5 ml per animal.
Method of administration:
Thermoformed pipettes:
Hold the pipette upright. Tap the narrow part of the pipette to ensure that the
contents are within the main body of the pipette. Break the snap-off top of the spot-on
pipette along the scored line.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents Repeat this
procedure at one or two different points along the cat’s back, preferably at the base
of the head and between the shoulders.
(Note: the shape of the marketed pipettes can be different as well as the pictures on
the marketed boxes/package leaflets.)
(Note : The pipettes can be marketed in a blister. In this case, the above images will
appear on the box and leaflet)
Polypropylene pipettes:
Remove the pipette from the blister packaging. Hold the pipette in an upright position,
twist and pull the cap off. Turn the cap around and place the other end of the cap
back on the pipette. Twist the cap to break the seal, then remove the cap from the
pipette.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents. Repeat this
procedure at one or two points along the cat’s back, preferably at the base of the
head and between the shoulders.

It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off, and to make sure that animals do not lick each
other following treatment.
Care should be taken to avoid excessive wetting of the hair with the veterinary
medicinal product since this will cause a sticky appearance of hairs at the treatment
spot. However, should this occur, it will disappear within 24 hours post application.
White deposits may also be seen at the site for up to 48 hours after application.
Treatment schedule:
For optimal control of flea and/or tick infestation the treatment schedule can be based
on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
In the absence of available data, the veterinary medicinal product should not be used
on kittens less than 2 months old and/or weighing less than 1 kg.
Do not use on sick (systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, due to a risk of adverse drug reactions or even death.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site reaction
(skin squamosis,
alopecia, pruritus, erythema)
Generalised itching, Alopecia general
Hypersalivation
Neurological disorders
(e.g.
Hyperaesthesia, central nervous system
depression

and neurological symptoms)
Vomiting
Transient cutaneous reactions at the application site.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Reversible symptoms.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
The veterinary medicinal product does not prevent ticks from attaching to the
animals. If the animal has been treated prior to exposure to the ticks, the ticks will be
killed in the first 24-48 hours after attachment. This will usually be prior to
engorgement, minimising but not excluding the risk of transmission of diseases.
Once dead, ticks will often drop off the animal, but any remaining ticks may be
removed with a gentle pull.
No data on the effect of bathing/shampooing on the efficacy of the veterinary
medicinal product in cats are available. However, based on information available for
dogs, shampooing an hour prior to treatment does not affect the efficacy of the
veterinary medicinal product against fleas.
For optimum control of flea problems in a multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.

Special precautions for safe use in the target species:
Avoid contact with the animal’s eyes. In the case of accidental eye contact,
immediately rinse the eyes with clean water.
Do not apply the veterinary medicinal product on wounds or damaged skin.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Keep pipettes in original packaging until ready to use.
People with a known hypersensitivity to fipronil or excipients (see section 2.) should
avoid contact with the veterinary medicinal product.
This veterinary medicinal product can cause mucous membrane and eye irritation.
Therefore, contact between the product and the mouth or eyes should be avoided.
In the case of accidental eye contact, immediately rinse the eyes with clean water. If
eye irritation persists seek medical advice and show the package leaflet or the label
to the physician.
Avoid contents coming into contact with the skin. If this occurs, wash hands with soap
and water.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product.
In case of accidental ingestion of product seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals should not be
allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application. Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
None known.
Store below 30C.
Store in a dry place.
Store in the original package.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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