DIB 1.0 g Vaginal Delivery System for Cattle

Vaginal use.
1.0 g of progesterone (1 device) per animal for 7-9 days (depending on indication).
The following protocols could be used:
For synchronisation of oestrus (including synchronisation of oestrus of donor and
recipient animals for embryo transfer):
- Insert one device into the vagina for 7 days.
- Inject a luteolytic dose of or analogue 24 hours prior to device removal.
- In animals that respond to treatment the onset of oestrus generally occurs within
1-3 days after removal of the insert. Cows should be inseminated within 12 hours of
first observed oestrus.
For the induction and synchronisation of oestrus for Fixed Time Artificial Insemination
(FTAI):
In cycling cows and heifers:
- Insert one device into the vagina for 7 days.
- Inject a luteolytic dose of or analogue 24 hours prior to device removal.
- FTAI 56 hours after removal of the device.
In cycling and non-cycling cows and heifers:
- Insert one device into the vagina for 7- 8 days.
- Inject a dose of GnRH or analogue at device insertion.
- Inject a luteolytic dose of or analogue 24 hours prior to device removal.

Revised: March 2025
AN: 03515/2024 & 03814/2024
- FTAI 56 hours after removal of the device, or
- Inject GnRH or analogue 36 hours after device removal and FTAI 16 to 20 hours
later.
In non-cycling cows:
- Insert one device into the vagina for 9 days.
- Inject a luteolytic dose of or analogue 24 hours prior to device removal.
- Inject eCG at device removal.
- FTAI 56 hours after removal of the device, or inseminate within 12 hours following
first observed oestrus behaviour.
Administration
The device specific applicator should be used for administration, following the
procedure described below:
1. Ensure that the applicator is clean and disinfected using a non-irritant antiseptic
solution before use.
2. Wearing sterile disposable plastic gloves, fold the arms of the device and load
into the applicator. The arms of the device should protrude slightly from the end
of the applicator. Care should be taken to avoid unnecessary or prolonged
handling of the product to minimise transfer of the active substance to the
operator's gloves.
3. Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4. Lift the tail and clean the vulva and perineum.
5. Gently insert the applicator into the vagina, first in a vertical direction and then
horizontally until some resistance is encountered.
6. Make sure the removal string is free, press the handle of the applicator and
allow the barrel to move back towards the handle. This releases the arms of the
device, which will then retain the device in the anterior vagina.
7. With the device correctly positioned, withdraw the applicator, leaving the
removal string hanging from the vulva.
8. The applicator should be cleaned and disinfected before being used on another
animal.
Removal
The device may be removed by gently pulling on the string. On occasions the string
may not be visible from the outside of the animal, in such cases it may be located in
the posterior vagina using a gloved finger. Withdrawal of the device should not
require force. If any resistance is encountered a gloved hand should be used to ease
removal.
If there is any difficulty in removal from the animal beyond that itemised above
veterinary advice must be sought.
The device is intended for single use only.

Revised: March 2025
AN: 03515/2024 & 03814/2024