POM-V Prescription Required

CIDR OVIS 0.35 g Vaginal Delivery System for Sheep

Active ingredient: Progesterone

Form

Vaginal delivery system

Species

Sheep

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3041

What it's used for

For the induction and synchronization of oestrus and ovulation in cycling and in non- cycling ewes for advancing the breeding season. To be used in combina...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Progesterone

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

CIDR OVIS 0.35 g Vaginal Delivery System for Sheep — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For the induction and synchronization of oestrus and ovulation in cycling and in non-
cycling ewes for advancing the breeding season.
To be used in combination with eCG (equine chorionic gonadotrophin).

One device should be inserted into the vagina of each ewe to be treated. The vaginal
insert should be left in position for 12 days followed by an injection of equine Chorionic
Gonadotrophin (eCG, formerly known as PMSG) administered at device removal. The
onset of oestrus occurs within 1-2 days after removal of the insert.
In a study of 11 Lacaune breed ewes, ovulation occurred between 42 and 58 hours
following eCG injection, with the majority (73%) ovulating between 50 and 54 hours. In
the case that artificial insemination and advanced breeding techniques (e.g. embryo
transfer) are applied, the timing of ovulation should be taken into consideration for the
selected technique for optimal results.
Administration:
A device applicator should be used for administration, following the procedure
described below:
1. Ensure that the applicator is clean and dipped in a non-irritant antiseptic solution
before use.
2. Wearing sterile disposable plastic gloves, fold the arms of the device and load
into the applicator. The arms of the device should protrude slightly from the end
of the applicator. Care should be taken to avoid unnecessary or prolonged
handling of the veterinary medicinal product to minimise transfer of the active
substance to the operator's gloves.
3. Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4. Lift the tail and clean the vulva and perineum.
5. Gently insert the applicator into the vagina, first in a vertical direction and then
horizontally until some resistance is encountered.
6. Make sure the removal string is free, press the handle of the applicator and allow the
barrel to move back towards the handle. This releases the arms of the device, which
will then retain the device in the anterior vagina.
7. With the device correctly positioned, withdraw the applicator, leaving the removal
string exiting from the vulva.
The applicator should be cleaned and disinfected before being used on another animal.
Removal:
The device may be removed by gently pulling on the tail. On occasions the tail of the
device may not be visible from the outside of the animal, in such cases it may be
located in the posterior vagina using a gloved finger. Approximately 1 in 10 devices may
be lost by an animal. Withdrawal of the device should not require force. If any resistance
is encountered a gloved finger should be used to ease removal.
If there is any difficulty in removal from the animal beyond that itemised above
veterinary advice must be sought.
The device is intended for single use only.

Do not use in sexually immature ewes or in females with abnormal genital tracts.
Do not use in animals presenting with infectious or non-infectious diseases of the
genital tract.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
See section 3.7

Sheep:
Common
(1 to 10 animals / 100 animals
treated):
Application site irritation
, vaginal discharge
(cloudy/yellow mucus)
Uncommon
(1 to 10 animals / 1,000 animals
treated):
Vaginal discharge
(dark red/brown mucus with
fresh blood)
typically resolve within 2 days of removal of the device without the need for
treatment.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section ’Contact
details’ of the package leaflet.

None.

Special precautions for safe use in the target species:
The efficacy and safety of the veterinary medicinal product has not been evaluated in
ewes which are unwell, which have a BCS < 2 or
during previous pregnancies or lambings, or which have lambed within the last 45 days.
Use only according to the benefit/risk assessment by the responsible veterinarian.
Animals in poor condition, whether from illness, inadequate nutrition, or other factors,
may respond poorly to treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Progesterone is a potent steroid hormone and may cause adverse effects on the
reproductive system in cases of high or prolonged exposure.
As adverse effects on unborn children cannot be ruled out, pregnant women should
avoid using this veterinary medicinal product.
The veterinary medicinal product may cause skin and eye irritation, as well as allergic
skin rashes. Avoid accidental contact with the eyes. In case of accidental ocular
exposure, flush the eyes thoroughly with water.
Persons administering the veterinary medicinal product should avoid contact with the
silicone section; pregnant women should avoid using the veterinary medicinal product.
The device should be inserted using the product specific applicator. Personal protective
equipment consisting of gloves should be worn when handling the veterinary medicinal
product during insertion and removal.
Wash hands and exposed skin with soap and water after use.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.

None known.

Do not store above 30 °C.

Meat and offal: zero days.
Milk: zero hours.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.