Curacef Duo, 50 mg/ml + 150 mg/ml Suspension for Injection for Cattle
Active ingredients: Ceftiofur, Ketoprofen
Form
Injection
Species
Manufacturer
Virbac
VMD MA No.
05653/3016
What it's used for
For the treatment of bovine respiratory disease (BRD) caused by haemolytica and of associated clinical signs of inflammation or pyrexia.
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Paying less for Ceftiofur + Ketoprofen
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1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Prescription required
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Curacef Duo, 50 mg/ml + 150 mg/ml Suspension for Injection for Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
haemolytica and
of associated clinical signs of inflammation or pyrexia.
ml/50 kg at each injection. The veterinary medicinal product should only be used
when the disease is associated with clinical signs of inflammation or pyrexia. The
veterinary medicinal product may be administered for 1 to 5 consecutive days
depending upon the clinical response on a case by case basis. As the duration for
the antibiotic treatment should not be less than 3 to 5 days, when inflammation and
pyrexia have subsided, the veterinarian should switch to a ceftiofur only-containing
product in order to cover 3 to 5 days of continuous antibiotic treatment. Only few
animals are expected to require a fourth or fifth injection with the combined product.
Shake the bottle vigorously for 20 seconds before use to ensure an homogeneous
suspension.
Resuspension could be longer after storage at low temperatures.
To ensure correct dosage body weight should be determined as accurately as
possible to avoid underdosing.
The user should use the most appropriate vial size according to the number of
animals to treat.
The 50 ml and 100 ml vials should not be pierced more than 10 times and the 250 ml
not more than 18 times. The use of an aspirating needle may be recommended to
avoid excessive broaching of the stopper.
Subsequent intramuscular injections must be given at different sites.
Not more than 16 ml should be administered per injection site.
Use preferably a 14 gauge needle.
AN: 03938/2022Page 5 of 8
antibiotics.
Do not use in cases of hypersensitivity to ceftiofur and other
Do not use in cases of hypersensitivity to ketoprofen.
AN: 03938/2022Page 2 of 8
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) and
corticosteroids concurrently or within 24 hours of each other.
Do not use in animals suffering from cardiac, hepatic or renal disease, where there is
the possibility of gastro-intestinal ulceration or bleeding, where there is evidence of a
blood dyscrasia.
Common
(1 to 10 animals / 100 animals
treated):
Injection site inflammation (e.g. Injection
site oedema)
.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reactions (e.g. Anaphylaxis,
allergic skin reaction)
Ruminant stomach disorder
Renal disorder
Skin discolouration and/or Muscle discolouration.
Mild and without pain in most cases.
Laboratory studies with ceftiofur or ketoprofen have shown occurrence of allergic
reaction the treatment should be withdrawn.
Unrelated to dose.
In common with all NSAIDs due to their action of inhibition of prostaglandin
synthesis.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the
national competent authority via the national reporting system. See also the
package leaflet for respective contact details.
AN: 03938/2022Page 4 of 8
Special precautions for safe use in the target species:
The veterinary medicinal product selects for resistant strains such as bacteria
carrying extended spectrum betalactamases (ESBL) and may constitute a risk to
human health if these strains disseminate to humans e.g. via food. For this reason,
the veterinary medicinal product should be reserved for the treatment of clinical
conditions which have responded poorly, or are expected to respond poorly (refers to
very acute cases when treatment must be initiated without bacteriological diagnosis)
to first line treatment.
When inflammation or pyrexia have subsided, the veterinarian should switch to a
ceftiofur only-containing
veterinary medicinal
product in order to cover 3 to 5 days
of continuous antibiotic treatment. Treating for an appropriate length of time is
important to limit development of resistance.
Official, national and regional antimicrobial policies should be taken into account
when the veterinary medicinal product is used. Increased use, including use of the
veterinary medicinal product deviating from the instructions given in the SPC, may
increase the prevalence of such resistance. Whenever possible, the veterinary
medicinal product should only be used based on susceptibility testing.
The veterinary medicinal product is intended for treatment of individual animals. Do
not use for disease prevention or as a part of herd health programmes. Treatment of
groups of animals should be strictly restricted to ongoing disease outbreaks
according to the approved conditions of use.
The concomitant use of diuretics or coagulant should be based on a benefit/risk
assessment of the responsible veterinarian.
Avoid intra-arterial and intravenous injection.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a
potential risk of increased renal toxicity.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead
to cross reactions to cephalosporins and vice versa. Ketoprofen may also cause
hypersensitivity. Allergic reactions to these substances may occasionally be serious.
AN: 03938/2022Page 3 of 8
Do not handle this veterinary medicinal product if you know you are sensitised to
active substances or to any of excipients, or if you have been advised not to work
with such preparations.
Wash hands after use.
Avoid contact with eyes and skin. In case of contact, wash immediately with water.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning.
Swelling of the face, lips or eyes or difficulty with breathing are more serious
symptoms and require urgent medical attention.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
highly bound drugs which can lead to toxic effects.
Do not use in combination with other NSAIDs or with corticosteroids, diuretics,
nephrotoxic drugs or anticoagulants.
The bactericidal properties of beta-lactams are neutralised by simultaneous use of
bacteriostatic antibiotics (macrolides, sulphonamides and tetracyclines).
Keep the glass vial in the outer carton in order to protect from light.
Milk: zero hours.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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