Credelio 450 mg Chewable Tablets for Dogs (>11–22 kg)
Active ingredient: Lotilaner
Form
Chewable
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/5007
What it's used for
For the treatment of flea and tick infestations in dogs. This veterinary medicinal product provides immediate and persistent killing activity for 1 month f...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Lotilaner
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Credelio 450 mg Chewable Tablets for Dogs (>11–22 kg) — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 18 Mar 2026.
This veterinary medicinal product provides immediate and persistent killing activity for 1
month for fleas (Ctenocephalides felis and C. canis) and ticks (Rhipicephalus
sanguineus, Ixodes ricinus, I. hexagonus and Dermacentor reticulatus).
Fleas and ticks must attach to the host and commence feeding in order to be exposed to
the active substance.
The veterinary medicinal product can be used as part of a treatment strategy for the
control of flea allergy dermatitis (FAD).
For the treatment of demodicosis (caused by Demodex canis).
Revised: January 2025
AN: 00194/2024
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Diarrhoea
1,2
, Bloody diarrhoea
, Vomiting
1,2
;
Anorexia
1,2
, Lethargy
, Polydipsia
1,2
;
Ataxia
, Convulsion
, Tremor
;
Pruritus
1,2
;
Inappropriate urination
, Polyuria
1,2
, Urinary
incontinence
1,2
Mild and transient
Typically resolve without treatment
Transient in most cases
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the last section of the package leaflet for respective
contact details.
Revised: January 2025
AN: 00194/2024
risk of the transmission of parasite borne diseases cannot be completely excluded.
i). Special precautions for use in animals
All safety and efficacy data have been acquired from dogs and puppies 8 weeks of age
and older and 1.3 kg of body weight and greater. Use of this veterinary medicinal product
in puppies younger than 8 weeks of age or less than 1.3 kg of body weight should be
based on a benefit-risk assessment by the responsible veterinarian.
ii). Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after handling the product.
In case of accidental ingestion, seek medical advice immediately and show the package
leaflet or the label to the physician.
iii) Other precautions
Not applicable
During clinical testing, no interactions between Credelio chewable tablets and routinely
used veterinary medicinal products were observed.
of 20– 43 mg/kg.
Credelio is a palatable chewable flavoured tablet. Administer the chewable tablet(s)
monthly with or after food.
For the treatment of demodicosis (caused by Demodex canis):
Monthly administration of the product for two consecutive months is efficacious and leads
to a marked improvement of clinical signs. Treatment should be continued until two
negative skin scrapings are obtained one month apart. Severe cases may require
prolonged monthly treatments. As demodicosis is a multi-factorial disease, where
possible, it is advisable to also treat any underlying disease appropriately.
Revised: January 2025
AN: 00194/2024
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No adverse reactions were observed following oral administration to puppies aged 8–9
weeks and weighing 1.3–3.6 kg treated with overdoses of up to 5 times the maximum
recommended dose (43 mg, 129 mg and 215 mg lotilaner/kg bodyweight) on eight
occasions at monthly intervals.
4.11 Withdrawal period(s)
Not applicable
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Lotilaner
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Advantage Chewable 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 225 mg Chewable Tablets for Dogs (>5.5–11 kg)
NFA-VPSElanco GmbH
Advantage Chewable 450 mg Chewable Tablets for Dogs (>11–22 kg)
NFA-VPSElanco GmbH
Advantage Chewable 56 mg Chewable Tablets for Dogs (1.3–2.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 900 mg Chewable Tablets for Dogs (>22–45 kg)
NFA-VPSElanco GmbH
Credelio 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
POM-VElanco GmbH
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