Advantage Chewable 225 mg Chewable Tablets for Dogs (>5.5–11 kg)
Active ingredient: Lotilaner
Form
Chewable
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/5048
What it's used for
For the treatment of flea and tick infestations in dogs. This veterinary medicinal product provides immediate and persistent killing activity for 1 month f...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Lotilaner
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
-
2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Advantage Chewable 225 mg Chewable Tablets for Dogs (>5.5–11 kg) — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 18 Mar 2026.
This veterinary medicinal product provides immediate and persistent killing
activity for 1 month for fleas (Ctenocephalides felis and C. canis) and ticks
(Rhipicephalus sanguineus, Ixodes ricinus, I. hexagonusDermacentor
reticulatus).
Fleas and ticks must attach to the host and commence feeding in order to be
exposed to the active substance.
The veterinary medicinal product can be used as part of a treatment strategy
for the control of Flea Allergy Dermatitis (FAD), where this has been previously
diagnosed by a veterinary surgeon.
Revised: December 2025
AN: 02790/2025
excipients.
Revised: December 2025
AN: 02790/2025
Very rare
(<1 animal / 10,000
animals treated, including
isolated reports):
Diarrhoea
1,2
, Bloody diarrhoea
, Vomiting
1,2
;
Anorexia
1,2
, Lethargy
, Polydipsia
1,2
Ataxia
, Convulsion
, Tremor
Pruritus
1,2
Inappropriate urination
, Polyuria
1,2
, Urinary
incontinence
1,2
Mild and transient
Typically resolve without treatment
Transient in most cases
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or the national
competent authority via the national reporting system. See also the last section
of the package leaflet for respective contact details.
therefore, the risk of the transmission of parasite borne diseases cannot be
completely excluded.
The possibility that other animals in the same household can be a source of re-
infection with fleas should be considered, and these should be treated as
necessary with an appropriate product.
All stages of fleas can infest the dog’s bedding and regular resting areas such
as carpets and soft furnishings. In case of massive flea infestation and at the
beginning of the control measures, these areas should be treated with a
suitable environmental product and then vacuumed regularly.
i). Special precautions for use in animals
All safety and efficacy data have been acquired from dogs and puppies 8
weeks of age and older and 1.3 kg of body weight and greater. In the absence
of available data, a veterinarian should be consulted before treatment in
puppies younger than 8 weeks of age or less than 1.3 kg of body weight.
Inform your veterinary surgeon that you are using this product if s/he provides
your dog with any other medication.
ii). Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Wash hands after handling the product.
Special precautions for the protection of the environment:
The active substance is mostly excreted in the faeces (poo) and may be toxic to
non-target organisms. In order to avoid contamination of the environment,
ensure that dog faeces are bagged up and disposed of safely.
iii) Other precautions
Not applicable
During clinical testing, no interactions between lotilaner and routinely used
veterinary medicinal products were observed.
conditions.
Active substance:
Each chewable tablet contains:
Advantage Chewable tabletslotilaner (mg)for dogs (>5.5–11 kg)225
Excipients:
For the full list of excipients, see section
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Lotilaner
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Advantage Chewable 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 450 mg Chewable Tablets for Dogs (>11–22 kg)
NFA-VPSElanco GmbH
Advantage Chewable 56 mg Chewable Tablets for Dogs (1.3–2.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 900 mg Chewable Tablets for Dogs (>22–45 kg)
NFA-VPSElanco GmbH
Credelio 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
POM-VElanco GmbH
Credelio 112 mg chewable tablets for dogs (>2.5–5.5 kg)
POM-VElanco GmbH
Alternative options to consider
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