Credelio 225 mg Chewable Tablets for Dogs (>5.5–11 kg)
Active ingredient: Lotilaner
Form
Chewable
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/5006
What it's used for
This veterinary medicinal product provides immediate and persistent killing activity for 1 month for fleas (Ctenocephalides felis and C. canis) and ticks (...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Lotilaner
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Credelio 225 mg Chewable Tablets for Dogs (>5.5–11 kg) — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
month for fleas (Ctenocephalides felis and C. canis) and ticks (Rhipicephalus sanguineus,
Ixodes ricinus, I. hexagonus and Dermacentor reticulatus).
Fleas and ticks must attach to the host and commence feeding in order to be exposed to
the active substance.
AN: 01311/2025Page 2 of 6
The veterinary medicinal product can be used as part of a treatment strategy for the
control of flea allergy dermatitis (FAD).
For reduction of the risk of infection with Babesia canis canis via transmission by
Dermacentor reticulatus for one month. The effect is indirect due to the activity of the
veterinary medicinal product against the vector.
For the treatment of demodicosis (caused by Demodex canis).
For the treatment of sarcoptic mange (Sarcoptes scabiei var canis).
table to ensure a dose of 20 to 43 mg lotilaner/kg bodyweight.
Strength and number of tablets to be administeredBody
weight of
dog (kg)
Credelio
56 mg
Credelio
112 mg
Credelio
225 mg
Credelio
450 mg
Credelio
900 mg
1.3–2.51>2.5–5.51>5.5–11.01>11.0–22.01>22.0–45.01>45 Appropriate combination of tablets
Use an appropriate combination of available strengths to achieve the recommended dose
of 20– 43 mg/kg.
Credelio is a palatable chewable flavoured tablet. Administer the chewable tablet(s)
monthly with or after food.
For the treatment of demodicosis (caused by Demodex canis):
AN: 01311/2025Page 4 of 6
Monthly administration of the product for two consecutive months is efficacious and leads
to a marked improvement of clinical signs. Treatment should be continued until two
negative skin scrapings are obtained one month apart. Severe cases may require
prolonged monthly treatments. As demodicosis is a multi-factorial disease, where
possible, it is advisable to also treat any underlying disease appropriately.
For the treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis):
Monthly administration of the product for two consecutive months. Further monthly
administration of the product may be required based on clinical assessment and skin
scrapings.
Very rare
(<1 animal / 10,000 animals
treated, including isolated reports):
Diarrhoea
1,2
, Bloody diarrhoea
, Vomiting
1,2
;
Anorexia
1,2
, Lethargy
; Polydipsia
1,2
;
Ataxia
, Convulsion
, Tremor
;
Pruritus
1,2
;
Inappropriate urination
, Polyuria
1,2
, Urinary
incontinence
1,2
Mild and transient
AN: 01311/2025Page 3 of 6
Typically resolve without treatment
Transient in most cases
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
risk of the transmission of parasite borne diseases cannot be completely excluded.
Specifically, as an acaricidal effect against D. reticulatus may take up to 48 hours,
transmission of B. canis canis during the first 48 hours cannot be excluded.
Special precautions for safe use in the target species:
All safety and efficacy data have been acquired from dogs and puppies 8 weeks of age
and older and 1.3 kg of body weight and greater. Use of this veterinary medicinal product
in puppies younger than 8 weeks of age or less than 1.3 kg of body weight should be
based on a benefit-risk assessment by the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after handling the product.
In case of accidental ingestion, seek medical advice immediately and show the package
leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
During clinical testing, no interactions between Credelio chewable tablets and routinely
used veterinary medicinal products were observed.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Lotilaner
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Advantage Chewable 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 225 mg Chewable Tablets for Dogs (>5.5–11 kg)
NFA-VPSElanco GmbH
Advantage Chewable 450 mg Chewable Tablets for Dogs (>11–22 kg)
NFA-VPSElanco GmbH
Advantage Chewable 56 mg Chewable Tablets for Dogs (1.3–2.5 kg)
NFA-VPSElanco GmbH
Advantage Chewable 900 mg Chewable Tablets for Dogs (>22–45 kg)
NFA-VPSElanco GmbH
Credelio 112 mg Chewable Tablets for Dogs (>2.5–5.5 kg)
POM-VElanco GmbH
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