Amphen 200 mg/ml Suspension for Use in Drinking Water for Pigs

The recommended dose is 10 mg florfenicol per kg bodyweight per day (equivalent to
5 mL of the product/100 kg bw) for 5 consecutive days.
To ensure a correct dosage body weight should be determined as accurately as
possible. In order to avoid under- and over-dosing, treated animals should be divided
into groups of similar bodyweight and the dose should be calculated for each group
individually.
Medicated water intake depends on many factors including the clinical condition of the
animal as well as local conditions such as ambient temperature and humidity. All
animals to be treated should have sufficient access to the water supply system to
ensure adequate consumption of the medicated drinking water. In order to ensure
consumption of the medicated water, animals should not have access to other water
supplies whilst being treated. If, however, it is not possible to obtain a sufficient intake
of medicated water, the animals should be treated parenterally.
The appropriate quantity of medicated water should be prepared based on the daily
water consumption. In order to obtain the correct dosage, the water uptake has to be
monitored and the concentration of florfenicol has to be adjusted accordingly.
Based on the recommended dose, and the number and weight of the animals to be
treated, the exact daily concentration of the veterinary product should be calculated
according to the following formula:
X mL veterinary medicinal
product/ kg body weight/day
x
Average body weight
(kg) of animals to be
treated
=
X ml veterinary product
per litre drinking water
Average daily water consumption (litre) per animal
If a weighing scale is used the required volume can be converted in grams as follows:
quantity in g of product required per day = number of ml of product required per day
x 1.075.
Accuracy of the dosing device should be thoroughly checked.
Shake the bottle vigorously for 60 seconds before use. The product should be added
to the water. Prepare the solution with fresh potable water.
For water tanks:
The maximal solubility is reached at concentrations of 2 mL/L (0.4 g of florfenicol/L),
2.5 mL/L (0.5 g of florfenicol/L) and 3 ml/L (0.6 g of florfenicol/L) at respectively 4°C,
10°C and 20°C. Solutions should be checked visually for complete dissolution.
To treat pigs drinking 10% of their bodyweight, at the dose of 10 mg/kg, add the
veterinary medicinal product to the drinking water in the tank.
Use 1L of product for every 2000 L of water. This corresponds to a concentration of
0.10 g florfenicol /L in the drinking water.
Mix thoroughly, to achieve full dissolution the solution should be stirred vigorously
using a manual whisk for 10 minutes. When using a magnetic stirrer at 100 rpm, the
mixing time is of 5 min.
For dosing pumps:
The veterinary medicinal product can only be used at the concentration of 50 mL/L
i.e. 10 g of florfenicol per litre of water of stock solution.
To treat pigs drinking 10% of their bodyweight, at the dose of 10 mg/kg, add the
veterinary medicinal product to the water in the reservoir of the dosing pump.
Add 1L of product to 20 L of unmedicated water. This corresponds to a concentration
of 10 g/L in the stock solution.
Mix thoroughly using a manual whisk for 10 minutes or automatic stirring device
operating at 840 rpm for 5 min until a homogeneous white milky suspension is
obtained.
Set the dosing pump on 1 % and turn on the dosing pump.
Medicated drinking water should be replaced every 24 hours.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.