Amflee 50 mg Spot-on Solution for Cats
Active ingredient: Fipronil
Form
Spot-on
Species
Manufacturer
KRKA, d.d., Novo mesto
VMD MA No.
01656/4086
What it's used for
reticulatus, Ixodes ricinus) infestations in cats. The veterinary medicinal product has a persistent insecticidal efficacy for up to 4 weeks against fleas...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Fipronil
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
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Amflee 50 mg Spot-on Solution for Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
The veterinary medicinal product has a persistent insecticidal efficacy for up to 4
weeks against fleas (Ctenocephalides spp.) and acaricidal efficacy for up to 4 weeks
against and for up to 1 week against Dermacentor reticulatus and
Rhipicephalus sanguineus. If Rhipicephalus sanguineus ticks are present when the
veterinary medicinal product is applied, all the ticks may not be killed within the first
48 hours but they may be killed within a week.
The veterinary medicinal product can be used as part of a treatment strategy for the
control of Flea Allergy Dermatitis (FAD), where this has been previously diagnosed
by a veterinary surgeon.
AN: 00885/2025 & 00893/2025
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible. Place the tip of the pipette onto the skin
and squeeze the pipette several times to empty its contents completely and
directly onto the skin in one spot.
It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off, and to make sure that animals do not lick each
other following treatment.
Temporary changes to the coat (clumped/greasy hair and/or deposits on the hair)
may be noted at the application site which normally disappears within 24 hours.
Treatment schedule:
For optimal control of flea and/or tick infestation the treatment schedule can be based
on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
AN: 00885/2025 & 00893/2025
absence of available data.
Do not use in sick (e.g. systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, as adverse reactions and even death could occur.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site skin squamosis
, Application site
alopecia
, Application site pruritus
, Application site
erythema
Generalized itching, Alopecia general
Hypersalivation Vomiting
Neurological signs
, Hyperaesthesia
Depression
Undetermined frequency
(cannot be estimated from the
available data)
Hypersalivation
1
Transient.
May be observed for a brief period in the case of licking the administration site.
Reversible.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
AN: 00885/2025 & 00893/2025
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
The veterinary medicinal product does not prevent ticks from attaching to the
animals. If the animal has been treated prior to exposure to the ticks, the tick will be
killed in the first 24-48 hours after attachment. This will usually be prior to
engorgement, minimising but not excluding the risk of transmission of diseases.
Once dead, ticks will often drop off the animal, but any remaining ticks may be
removed with a gentle pull.
No data on the effect of bathing/shampooing on the efficacy of the veterinary
medicinal product in cats are available. However, based on information available for
dogs, weekly immersion in water for one minute reduces the period of persistent
insecticidal efficacy against fleas by one week.
For optimal control of flea infestation in a multi-pet household, all animals in the
household (e. g. dogs, cats, ferrets, rabbits) should be treated with a suitable
insecticide.
When used as part of a strategy for the treatment of Flea Allergy Dermatitis, monthly
applications to the allergic patient is recommended and other dogs and cats in the
household should be treated with a suitable insecticide.
Special precautions for safe use in the target species:
Avoid contact with the animal's eyes. In the case of accidental eye contact,
immediately and thoroughly flush the eyes with water.
Do not apply the veterinary medicinal product on wounds or damaged skin.
It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off and to make sure that animals do not lick each
other following treatment.
AN: 00885/2025 & 00893/2025
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane and eye irritation.
Therefore, contact between the veterinary medicinal product and the mouth or eyes
should be avoided.
In the case of accidental eye contact, immediately and thoroughly flush the eyes with
water. If eye irritation persists seek medical advice immediately and show the
package leaflet or the label to the physician.
Avoid contents coming into contact with the fingers. If this occurs, wash off
immediately with soap and water.
Wash hands after use.
Do not smoke, drink or eat during application.
People with known hypersensitivity to fipronil or dimethyl sulfoxide or other excipients
should avoid contact with the veterinary medicinal product.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals should not be
allowed to sleep with owners, especially children.
Keep pipettes in original packaging and dispose of used pipettes immediately.
Special precautions for the protection of the environment:
Not applicable.
remove from bag until required for use.
The product should be maintained at room temperature (above 14° C) for
approximately one hour prior to administration.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Fipronil
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Alfamed 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
POM-VAlfamed
Alfamed 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
POM-VAlfamed
Alfamed Fipronil 134 mg Spot-on Solution for Medium Dogs
NFA-VPSAlfamed
Alfamed Fipronil 134 mg Spot-on Solution for Medium Dogs
NFA-VPSAlfamed
Alfamed Fipronil 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
POM-VAlfamed
Alfamed Fipronil 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
POM-VAlfamed
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