AVM-GSL
Over the Counter
Companion Animal
Zerotal Plus 50 mg/60 mg Spot-on Solution for Cats and Ferrets
Active ingredients: (S)-Methoprene, Fipronil
Form
Spot-on
Species
Cats
Ferrets
Manufacturer
Chanelle Pharmaceuticals Manufacturing Ltd
VMD MA No.
08749/5167
What it's used for
In cats: - To be used against infestations with fleas, alone or in association with ticks and/or biting lice. - Elimination of fleas (Ctenocephalides spp.)...
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Paying less for (S)-Methoprene + Fipronil
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Clinical information
Zerotal Plus 50 mg/60 mg Spot-on Solution for Cats and Ferrets — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
In cats:
- To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of
fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for six weeks after
application.
- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus
sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks
against ticks (based on experimental data).
- Elimination of biting lice (Felicola subrostratus).
Revised: November 2025
AN: 02292/2025
In ferrets:
- To be used against infestations with fleas, alone or in association with ticks.
- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of
fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas.
- Elimination of ticks (Ixodes ricinus,). The product has a persistent acaricidal efficacy
for 4 weeks against ticks (based on experimental data).
- To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of
fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for six weeks after
application.
- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus
sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks
against ticks (based on experimental data).
- Elimination of biting lice (Felicola subrostratus).
Revised: November 2025
AN: 02292/2025
In ferrets:
- To be used against infestations with fleas, alone or in association with ticks.
- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of
fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas.
- Elimination of ticks (Ixodes ricinus,). The product has a persistent acaricidal efficacy
for 4 weeks against ticks (based on experimental data).
For external use only, topical spot-on application to the skin. Animals should be
weighed accurately prior to treatment.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and
60 mg for (S)-methoprene per ferret, by topical application to the skin.
Do not overdose
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Avoid contact with the animal’s eyes.
Revised: November 2025
AN: 02292/2025
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
weighed accurately prior to treatment.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and
60 mg for (S)-methoprene per ferret, by topical application to the skin.
Do not overdose
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Avoid contact with the animal’s eyes.
Revised: November 2025
AN: 02292/2025
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
In the absence of available data, do not use the product on kittens less than 8 weeks
old and/or weighing less than 1 kg. Do not use the product on ferrets less than 6
months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse drug reactions, including death, could occur.
In absence of studies, do not use the product in non-target species.
Do not use in known cases of hypersensitivity (allergy) to the active substances
(Fipronil or (S)-methoprene) or to any other excipients (ingredients).
old and/or weighing less than 1 kg. Do not use the product on ferrets less than 6
months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse drug reactions, including death, could occur.
In absence of studies, do not use the product in non-target species.
Do not use in known cases of hypersensitivity (allergy) to the active substances
(Fipronil or (S)-methoprene) or to any other excipients (ingredients).
Cats
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use.
Excessive salivation, reversible nervous signs (increased sensitivity to stimulation,
depression, other nervous signs) or vomiting have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
Revised: November 2025
AN: 02292/2025
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use.
Excessive salivation, reversible nervous signs (increased sensitivity to stimulation,
depression, other nervous signs) or vomiting have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
Revised: November 2025
AN: 02292/2025
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).
Other animals living in the same household should also be treated with a suitable
product.
No data on the effect of bathing/shampooing on the efficacy of the product in cats
and ferrets are available. However, based on information available for dogs
shampooed as from 2 days after application of the product, it is not recommended to
bath animals within 2 days after application of the product.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly. When treating infestations of parasites, all in-contact
animals should be treated with an appropriate product at the same time.
Special precautions for use in animals
For external use only. Do not administer orally.
Avoid contact with the animal's eyes. If the product is in contact with eyes, rinse
immediately with plenty of water.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment. Do not apply the product on wounds or skin lesions.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
Revised: November 2025
AN: 02292/2025
The attachment of single ticks after treatment cannot be ruled out. Therefore, the
transmission of infectious diseases cannot be completely excluded if conditions are
unfavourable.
For use during pregnancy, lactation or lay see section 4.7.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep the pipettes in the original packaging until ready to use and dispose of used
pipettes immediately.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product.
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
Avoid contents coming into contact with the fingers. If this occurs, wash hands with
soap and water.
After accidental ocular exposure the eye should be rinsed carefully with clean water.
If eye irritation persists, seek medical advice immediately and show the package
leaflet or label to the physician.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in watercourses for 2 days after application.
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
product.
No data on the effect of bathing/shampooing on the efficacy of the product in cats
and ferrets are available. However, based on information available for dogs
shampooed as from 2 days after application of the product, it is not recommended to
bath animals within 2 days after application of the product.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly. When treating infestations of parasites, all in-contact
animals should be treated with an appropriate product at the same time.
Special precautions for use in animals
For external use only. Do not administer orally.
Avoid contact with the animal's eyes. If the product is in contact with eyes, rinse
immediately with plenty of water.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment. Do not apply the product on wounds or skin lesions.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
Revised: November 2025
AN: 02292/2025
The attachment of single ticks after treatment cannot be ruled out. Therefore, the
transmission of infectious diseases cannot be completely excluded if conditions are
unfavourable.
For use during pregnancy, lactation or lay see section 4.7.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep the pipettes in the original packaging until ready to use and dispose of used
pipettes immediately.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product.
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
Avoid contents coming into contact with the fingers. If this occurs, wash hands with
soap and water.
After accidental ocular exposure the eye should be rinsed carefully with clean water.
If eye irritation persists, seek medical advice immediately and show the package
leaflet or label to the physician.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in watercourses for 2 days after application.
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
the animal.
Do not store above 30°C.
Store in the original package.
Store in the original package.
Ferrets
Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic
or maternotoxic effects. The safety of the veterinary medicinal product has not been
established in ferrets during pregnancy and lactation. Use only according to the risk-
benefit assessment by the responsible veterinarian.
4.8 Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with other flea products which are applied directly on to
the animal.
4.9 Amounts to be administered and administration route
For external use only, topical spot-on application to the skin. Animals should be
weighed accurately prior to treatment.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and
60 mg for (S)-methoprene per ferret, by topical application to the skin.
Do not overdose
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Avoid contact with the animal’s eyes.
Revised: November 2025
AN: 02292/2025
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of experiencing adverse effects may increase with overdosing (see section
4.6).
Cats
No undesirable effects were observed in target animal safety studies in cats and
kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five
times the recommended dose for six consecutive months.
Itching may occur following treatment.
Overdose application of the product will cause a sticky appearance of hairs at the
treatment spot. However, should this occur, it will disappear within 24 hours post
application.
Ferrets
In ferrets aged 6 months and older and treated once every 2 weeks for four
treatments, at five times the recommended dose, bodyweight loss was observed in
some animals.
4.11 Withdrawal Period(s)
Not applicable.
5.
Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic
or maternotoxic effects. The safety of the veterinary medicinal product has not been
established in ferrets during pregnancy and lactation. Use only according to the risk-
benefit assessment by the responsible veterinarian.
4.8 Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with other flea products which are applied directly on to
the animal.
4.9 Amounts to be administered and administration route
For external use only, topical spot-on application to the skin. Animals should be
weighed accurately prior to treatment.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and
60 mg for (S)-methoprene per ferret, by topical application to the skin.
Do not overdose
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Avoid contact with the animal’s eyes.
Revised: November 2025
AN: 02292/2025
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of experiencing adverse effects may increase with overdosing (see section
4.6).
Cats
No undesirable effects were observed in target animal safety studies in cats and
kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five
times the recommended dose for six consecutive months.
Itching may occur following treatment.
Overdose application of the product will cause a sticky appearance of hairs at the
treatment spot. However, should this occur, it will disappear within 24 hours post
application.
Ferrets
In ferrets aged 6 months and older and treated once every 2 weeks for four
treatments, at five times the recommended dose, bodyweight loss was observed in
some animals.
4.11 Withdrawal Period(s)
Not applicable.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
Other Products Containing (S)-Methoprene
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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Bob Martin Clear Plus 402 mg/ 361.8 mg Spot-on Solution for Extra Large Dogs
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Bob Martin Clear Plus 402 mg/ 361.8 mg Spot-on Solution for Extra Large Dogs
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