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AVM-GSL Over the Counter Companion Animal

Bob Martin Clear Plus 268 mg/ 241.2 mg Spot-on Solution for Large Dogs

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Pets Choice Healthcare Limited

VMD MA No.

61560/3008

What it's used for

For the treatment of dogs weighing 20 kg to 40 kg bodyweight - To be used against infestations with fleas, alone or in association with ticks and/or biting...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Bob Martin Clear Plus 268 mg/ 241.2 mg Spot-on Solution for Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of dogs weighing 20 kg to 40 kg bodyweight
- To be used against infestations with fleas, alone or in association with ticks
and/or biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy
against new infestations with adult fleas persist for 8 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for eight
weeks after application.
- Treatment of tick infestations (Ixodes
Dermacentor reticulatus, ) The product has a persistent
acaricidal efficacy for up to 4 weeks against ticks.
- Treatment of infestations with biting lice (Trichodectes canis).

Revised: October 2025
AN: 02133/2025Page 2 of 8
One pipette of 2.68 ml per dog weighing over 20 kg and up to 40 kg, corresponding
to a minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-
methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.

Revised: October 2025
AN: 02133/2025Page 4 of 8
Method of administration:
Weigh the dog first and ensure that correct product is used for the weight of the
dog.
Thermoformed pipettes:
1. Bob Martin Clear Plus must be applied at 2 points, at the base of the back of
the dog’s head and between the shoulder blades. If the dog is wearing a
collar, remove it first so that it does not restrict application.
2. Remove a single pipette from the pack. To open, hold the pipette upright and
snap off the tip.
3. Part your dog’s coat until the skin is visible. Place the tip of the pipette directly
against the skin and squeeze gently. Apply approximately half the pipette at
one point and half at the second point
Polypropylene pipettes

1. Bob Martin Clear Plus must be applied at 2 points – at the base of the back of
the dog’s head and between the shoulder blades. If the dog is wearing a collar
remove it first so that it does not restrict application.
2. Remove a single pipette from the pack. Hold the pipette upright and snap off
the top section of the cap opening the pipette.

Revised: October 2025
AN: 02133/2025Page 5 of 8
3. Part your dog’s coat until the skin is visible. Place the tip of the pipette directly
against the skin and squeeze gently. Apply approximately half the pipette at
the base of the back of the dog’s head and half between the dog’s shoulder
blades. Squeeze the pipette several times to ensure dosing is complete.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
In the absence of available data, the product should not be used on puppies less
than 8 weeks old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur.
absence of studies, the use of the product is not recommended in non-target species.
This product is specifically developed for dogs. Do not use in cats and ferrets, as this
could lead to overdosing.
Do not use in known cases of hypersensitivity to the active substances or to any of
the excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (skin discoloration, local hair loss, itching, redness) and general
itching or hair loss have been reported after use. Excessive salivation, reversible
nervous signs (increased sensitivity to stimulation, depression, other nervous signs),
vomiting or respiratory symptoms have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier .
Do not overdose.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time.

Special precautions for use in animals
Avoid contact with the animal’s eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Animals should be weighed accurately prior to treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep pipettes in original packaging until ready to use.
This product can cause mucous membrane, skin and eye irritation. Avoid contents
coming into contact with your mouth, skin and eyes.
If skin contact does occur, wash it off quickly and thoroughly with soap and water.
In case of accidental eye contact, immediately and thoroughly flush the eyes with
clean water.
If the product is accidentally swallowed, or irritation of the eye persists, seek medical
advice and show the packaging to the physician.
Do not smoke, drink or eat during application.

Revised: October 2025
AN: 02133/2025Page 3 of 8
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product.
Treated animals should not be handled until the application site is dry; in particular,
children should not be allowed to play with treated animals until the application site is
dry. It is therefore recommended that animals are not treated during the day, but
during the early evening.
Recently treated animals should not be allowed to sleep with owners, especially
children.
Wash hands thoroughly after use with soap and water.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in watercourses for 2 days after application.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
Do not store above 25C.
Store in the original package.
Store in a dry place.

Revised: October 2025
AN: 02133/2025Page 7 of 8
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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