Zermex 0.5% w/v Pour-on Solution for Cattle

Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:
•
over an extended period of time.
•
misadministration of the product, or lack of calibration of the dosing
device (if any).
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
To date, no resistance to moxidectin in cattle parasites has been reported.
The use of this product should be based on local (regional, farm)
epidemiological information about susceptibility of the nematodes and
recommendations on how to limit further selection for resistance to
anthelmintics.

Revised: January 2025
AN: 02727/2024

i. Special precautions for use in animals
To avoid secondary reactions due to the death of Hypoderma larvae in
the oesophagus or the spine, it is recommended to administer the
product at the end of the period of fly activity and before the larvae reach
their resting sites: consult the veterinarian to know the correct treatment
period.
For external use only.
For topical application only.
ii. Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Avoid direct contact with skin and eyes.
If splashed in the eye or on the skin, wash with plenty of clean, running
water immediately.
Seek medical advice if irritation persists.
Wear protective clothes and impermeable gloves when applying the
product.
Do not eat, drink or smoke whilst handling the product.
Wash hands after use.
iii. Other precautions regarding impact on the environment
Moxidectin fulfils the criteria for a (very) persistent, bioaccumulative and
toxic (PBT) substance; therefore, exposure of the environment to
moxidectin must be limited to the extent possible. Treatments should be
administered only when necessary and should be based on faecal egg
counts or evaluation of the risk of infestation at the animal and/or herd
level.
Like other macrocyclic lactones, moxidectin has the potential to
adversely affect non-target organisms:
•
animals may temporarily reduce the abundance of dung feeding
organisms. Following treatment of cattle with the product, levels of
moxidectin that are potentially toxic to dung fly species may be
excreted over a period more than 2 weeks and may decrease dung
fly abundance during that period. It has been established in
laboratory tests that moxidectin may temporarily affect dung beetle
reproduction; however, field studies indicate no-long term effects.
Nevertheless, in case of repeated treatments with moxidectin (as
with products of the same anthelmintic class) it is advisable not to
treat animals every time on the same pasture to allow dung fauna
populations to recover.
•
The product should be used only according to the label instructions.
Based on the excretion profile of moxidectin when administered as

Revised: January 2025
AN: 02727/2024
the pour-on formulation, treated animals should not have access to
watercourses during the first week after treatment.