Advocate 100 mg + 25 mg Spot-on Solution for Medium Dogs (> 4–10 kg)

Dosage schedule:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 2.5
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of the veterinary
medicinal product.
For treatment or prevention of infestations with the parasites indicated for use of this
veterinary medicinal product, the need for and frequency of re-treatment(s) should be
based on professional advice and should take into account the local epidemiological
situation and the animal’s lifestyle.
Weight of
dog
[kg]
Pipette size to be usedVolume
[ml]
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
 4 kgAdvocate for small dogs0.4minimum of 10minimum of
2.5
> 4–10 kgAdvocate for medium dogs1.010–252.5–6.25> 10–25 kgAdvocate for large dogs2.510–252.5–6.25> 25–40 kgAdvocate for extra-large
dogs
4.010–162.5–4> 40 kgthe appropriate combination of pipettes
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine the veterinary
medicinal product treatment with environmental treatments aimed at breaking the flea
life cycle in the surroundings. This can result in a more rapid reduction in the
household flea population. The veterinary medicinal product should be administered
at monthly intervals when used as part of a treatment strategy for flea allergy
dermatitis.
Treatment of biting lice (Trichodectes canis)
A single dose should be administered. A further veterinary examination 30 days after
treatment is recommended as some animals may require a second treatment.
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the veterinary medicinal product should be administered. Loose
debris should be gently removed from the external ear canal at each treatment. A
further veterinary examination 30 days after treatment is recommended as some
animals may require a second treatment. Do not apply directly to the ear canal.
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis)
A single dose should be administered twice 4 weeks apart.
Treatment of demodicosis (caused by Demodex canis)
The administration of a single dose every 4 weeks for 2 to 4 months is efficacious
against
particularly in mild to moderate cases. Especially severe cases may require more
prolonged and more frequent treatment. To achieve the best possible response in
these severe cases, at the discretion of the veterinarian, the veterinary medicinal
product can be applied once a week and for a prolonged time. In all cases it is
essential that the treatment should be continued until skin scrapings are negative on
at least 2 consecutive monthly occasions. Treatment should be stopped in dogs that
show no improvement or do not respond in mite count after 2 months treatment.
Alternative treatment should be administered. Seek the advice of your veterinarian.
As demodicosis is a multi-factorial disease, where possible, it is advisable to also
treat any underlying disease appropriately.
Prevention of heartworm disease (D. immitis)
Dogs in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 4.5 should be
considered.
For prevention of heartworm disease, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit D. immitis larvae) are present. The
veterinary medicinal product may be administered throughout the year. The first dose
may be given after first possible exposure to mosquitoes, but not more than one
month after this exposure. Treatment should continue at regular monthly intervals
until 1 month after the last exposure to mosquitoes. To establish a treatment routine,
it is recommended that the same day or date be used each month. When replacing
another heartworm preventative product in a heartworm prevention programme, the
first treatment with the veterinary medicinal product must be given within 1 month of
the last dose of the former medication.
In non-endemic areas there should be no risk of dogs having heartworm. Therefore,
they can be treated without special precautions.
Prevention of cutaneous dirofilariosis (skin worm) (D. repens)
For prevention of cutaneous dirofilariosis, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit D. repens larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
month before the first expected exposure to mosquitoes. Treatment should continue
at regular monthly intervals until 1 month after the last exposure to mosquitoes. To
establish a treatment routine, it is recommended that the same day or date be used
each month.
Treatment of microfilariae (D. immitis)
The veterinary medicinal product should be administered monthly for two consecutive
months.
Treatment of cutaneous dirofilariosis (skin worm) (adult stages of Dirofilaria repens)
The veterinary medicinal product should be administered monthly for six consecutive
months.
Reduction of microfilariae (skin worm) (D. repens)
The veterinary medicinal product should be administered monthly for four
consecutive months.
Treatment and prevention of Angiostrongylus vasorum
A single dose should be administered. A further veterinary examination 30 days after
treatment is recommended as some animals may require a second treatment.
In endemic areas regular monthly applications will prevent angiostrongylosis and
patent infection with Angiostrongylus vasorum.
Treatment of Crenosoma vulpis
A single dose should be administered.
Prevention of spirocercosis (Spirocerca lupi)
The veterinary medicinal product should be administered monthly.
Treatment of Eucoleus (syn. Capillaria) boehmi (adults)
The veterinary medicinal product should be administered monthly for two consecutive
months. It is advisable to prevent auto-coprophagia between the two treatments in
order to prevent possible reinfection.
Treatment of the eye worm Thelazia callipaeda (adults)
A single dose of the veterinary medicinal product should be administered.
Roundworm, hookworm and whipworm treatment Toxocara canis, Ancylostoma
caninum, Uncinaria stenocephalaToxascaris leonina and Trichuris vulpis)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective round-, hook- and whipworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Studies have shown that monthly treatment of dogs will prevent infections caused by
Uncinaria stenocephala.
Method of administration
External use.
Remove one pipette from the package. Then hold the pipette in an upright position,
and twist and pull off the cap. Reverse the cap and use it to twist and remove the
seal from the pipette, as shown.

With the dog in a standing position, part the coat between the shoulder blades until
the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the
pipette on the skin and squeeze the pipette firmly several times to empty its contents
directly onto the skin.