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AVM-GSL Over the Counter Companion Animal

VetUK Flea & Tick Treatment Plus for Medium Dogs 134 mg/120.6 mg Spot-on Solution (Fipronil and S-Methoprene)

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

EU Pharmaceuticals Ltd

VMD MA No.

39787/5028

What it's used for

For the treatment of dogs weighing 10 -to-20 kg bodyweight: - To be used against infestations with fleas, alone or in association with ticks and/or biting...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

VetUK Flea & Tick Treatment Plus for Medium Dogs 134 mg/120.6 mg Spot-on Solution (Fipronil and S-Methoprene) — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of dogs weighing 10 -to-20 kg bodyweight:
- To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persist for 8 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for eight weeks after
application.
- Treatment of tick infestations (Ixodes ricinus, , Dermacentor
reticulatus, Rhipicephalus sanguineus). The product has a persistent acaricidal
efficacy for up to 4 weeks against ticks.
- Treatment of infestations with biting lice (Trichodectes canis).

Revised: November 2025
MA split from NI Expiry following AN: 02223/2025Page 2 of 6
One pipette of 1.34 ml (S) per dog weighing over 10 and up to 20 kg, corresponding
to a minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-
methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site. Do not overdose.

Revised: November 2025
MA split from NI Expiry following AN: 02223/2025Page 4 of 6
In the absence of available data, the product should not be used on puppies less
than 8 weeks old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, due to a risk of adverse drug reactions or even death. In
absence of studies, the use of the product is not recommended in non-target
species.
This product is specifically developed for dogs. Do not use in cats, as this could lead
to overdosing.
Do not use in known cases of hypersensitivity to the active substance or to any of
the excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (skin discoloration, local hair loss, itching, redness) and general
itching or hair loss have been reported after use. Excessive salivation, reversible
nervous signs (increased sensitivity to stimulation, depression, other nervous signs),
vomiting or respiratory symptoms have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly
to the nature of the carrier.
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.

Special precautions for use in animals
Avoid contact with the animal's eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
People with a known hypersensitivity to insecticides or alcohol should avoid contact
with the product. Avoid contents coming into contact with the fingers. If this occurs,
wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with clean water.
If the product is accidently swallowed, seek medical advice immediately and show
the package leaflet to the physician.
Wash hands after use.

Revised: November 2025
MA split from NI Expiry following AN: 02223/2025Page 3 of 6
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Keep stored pipettes in the original packaging until ready to use. In order to prevent
children from getting access to used pipettes, dispose of used pipettes immediately.
Do not smoke, drink or eat during application.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in watercourses for 2 days after application.
None known.
Do not store above 30°C.
Store in the original package.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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