Vetoryl 5 mg Hard Capsules for Dogs

An accurate diagnosis of hyperadrenocorticism is essential.
Where there is no apparent response to treatment, the diagnosis should be re-
evaluated. Dose increases may be necessary.
Veterinarians should be aware that dogs with hyperadrenocorticism are at increased
risk of pancreatitis. This risk may not diminish following treatment with trilostane.

Special precautions for safe use in the target species:
As the majority of cases of hyperadrenocorticism are diagnosed in dogs between the
ages of 10-15 years, other pathological processes are frequently present. It is
particularly important to screen cases for primary hepatic disease and renal
insufficiency as the veterinary medicinal product is contraindicated in these cases.
Subsequent close monitoring during treatment should be carried out. Particular
attention should be paid to liver enzymes, electrolytes, urea and creatinine.
The presence of diabetes mellitus and hyperadrenocorticism together requires
specific monitoring.
If a dog has previously been treated with mitotane, its adrenal function will have been
reduced. Experience in the field suggests that an interval of at least a month should
elapse between cessation of mitotane and the introduction of trilostane. Close
monitoring of adrenal function is advised, as dogs may be more susceptible to the
effects of trilostane.
The veterinary medicinal product should be used with extreme caution in dogs with
pre-existing anaemia as further reductions in packed-cell volume and haemoglobin
may occur. Regular monitoring should be undertaken.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Trilostane may decrease testosterone synthesis and has anti-progesterone
properties. Women who are pregnant or are intending to become pregnant should
avoid handling the capsules.
Wash hands with soap and water following accidental exposure and after use.
The content of the capsules may cause skin and eye irritation and sensitisation. Do
not divide or open capsules: in the event of accidental breakage of the capsules and
contact of the granules with eyes or skin, wash immediately with plenty of water. If
irritation persists, seek medical advice and show the package leaflet/label to the
physician
People with known hypersensitivity to trilostane or any of the excipients should avoid
contact with the veterinary medicinal product.

Amended pages: March 2025
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Not applicable.