POM-V Prescription Required

Vectormune ND Suspension and Solvent for Suspension for Injection

Active ingredient: Turkey herpesvirus

Form

Injection

Species

Chickens

Manufacturer

Ceva Animal Health Ltd

VMD MA No.

15052/5030

What it's used for

For active immunisation of 18-day-old embryonated chicken eggs or one-day-old chicks to reduce mortality and clinical signs caused by Newcastle disease vir...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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1

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Clinical information

Vectormune ND Suspension and Solvent for Suspension for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For active immunisation of 18-day-old embryonated chicken eggs or one-day-old chicks
to reduce mortality and clinical signs caused by Newcastle disease virus and to reduce
mortality, clinical signs and lesions caused by virulent Marek’s disease virus.
Onset of immunity against Newcastle disease for broilers and layers: 3 weeks of age.
Duration of immunity against Newcastle disease for broilers: 9 weeks of age.
Duration of immunity against Newcastle disease for layers: 18 weeks of age
Onset of immunity against Marek’s disease for broilers and layers: 1 week of age.
Duration of immunity for broilers and layers: A single vaccination is sufficient to provide
protection during the risk period of infection with Marek’s disease virus.

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For in-ovo administration and subcutaneous use.
In-ovo administration:
One single dose of 0.05 ml is injected into each 18-day-old embryonated broiler chicken
egg. For in-ovo application an automatic in-ovo egg injector can be used. In-ovo
equipment should be calibrated to ensure that a 0.05 ml dose is applied to each egg.
Subcutaneous use:
One single injection of 0.2 ml per chick is applied for broilers or layers at one day of
age. The vaccine may be injected by an automatic syringe.
Overview table for dilution possibilities of different presentations:
For in-ovo administration:
Vaccine ampoule presentation
(No. of vaccine ampoules
multiplied by doses needed)
Solvent
presentation
(ml)
Volume of one
dose
(ml)
2 x 2,0002000.051 x 4,0002000.052 x 4,0004000.054 x 4,0008000.055 x 4,00010000.056 x 4,00012000.058 x 4,00016000.05
The speed of automatic injection is at least 2,500 eggs per hour, therefore solvent
presentation of at least or more than 400 ml is recommended to prime and inject for

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AN: 00764/2024 Page 5 of 8
longer than 10 minutes. In-ovo equipment should be calibrated to ensure that a 0.05 ml
dose is applied to each egg.
Solvent presentations smaller than 400 ml are not recommended to be used for in-ovo
application by an automated machine as it may not be enough to prime the machine and
to inject for longer than 10 minutes. The 200 ml presentation may be used for manual
vaccination.
For subcutaneous use:
Vaccine ampoule presentation
(No. of vaccine ampoules
multiplied by doses needed)
Solvent
presentation
(ml)
Volume of one
dose
(ml)
1 x 1,0002000.201 x 2,0004000.202 x 2,0008000.201 x 4,0008000.204,000 + 1,00010000.203 x 2,00012000.202 x 4,00016000.20
The usual aseptic precautions should be applied to all administration procedures. Be
familiar with all safety and precautionary measures for handling liquid nitrogen in
order to prevent personal injury.
Preparation of vaccine suspension for injection:
1. After matching the dose size of the vaccine ampoule presentation with the solvent
bag size, quickly remove the exact number of ampoules needed from the liquid
nitrogen container.
2. Draw up 2 ml of solvent into a 5 ml syringe.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27–
39 °C.
4. As soon as they are completely thawed, open ampoules holding them at arm’s
length in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open, slowly draw up the content into the 5 ml sterile syringe
already containing 2 ml of solvent with a needle of at least 18 gauge diameter.
6. Transfer the suspension into the solvent bag. The diluted vaccine prepared as
described is mixed by gentle agitation.
7. Withdraw a portion of the diluted vaccine into the syringe to rinse the ampoule.
Remove the washing from the ampoule and inject it gently into the solvent bag.
Repeat one or two times.
8. The diluted vaccine prepared as described is mixed by gentle agitation so as to be
ready for use.
Repeat the operations in point 2 to 7 for the appropriate number of ampoules to be
thawed.
Use the vaccine immediately, slowly mix regularly to ensure uniform suspension of cells
and use within a period not exceeding 2 hours.
After adding the content of the ampoule to the solvent, the ready to use product is a
clear, red coloured suspension for injection.

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AN: 00764/2024 Page 6 of 8
Discard any ampoules that have been accidentally thawed. Do
not re-freeze under any circumstances.
Do not re-use opened containers of diluted vaccine.

None.

None known.

Vaccinate healthy animals only.

Special precautions for use in animals
The vaccine strain was shown to be excreted by chickens and there was a slow spread to
turkeys which was not detectable at 35 days but was detectable after 42 days of a
contact study. Safety trials show the excreted vaccine strain is not harmful in turkeys;
however, special precautions should be taken to avoid spreading of the vaccine strain to
turkeys.
No spread was demonstrated between chickens.
It should be ensured that the vaccine suspension is mixed regularly in a gentle way
during the vaccination session to guarantee that the vaccine suspension remains
homogenous and that the correct vaccine virus titre is administered (e.g. when
automatic in-ovo injection machines are used or during long vaccination sessions).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Liquid nitrogen containers and vaccine ampoules should be handled by properly trained
personnel only.
Personal protective equipment consisting of protective gloves, spectacles and boots
should be worn when handling the veterinary medicinal product, before withdrawing
from liquid nitrogen, during the ampoule thawing and opening operations.
Frozen glass ampoules may explode during sudden temperature changes. Store and
use liquid nitrogen only in a dry and well-ventilated place. Inhalation of the liquid
nitrogen is dangerous.
Personnel involved in the treatment of vaccinated birds should follow hygiene principles
and take particular care in handling litter from vaccinated chickens.

Safety and efficacy data are available which demonstrate that this vaccine can be mixed
and administered with Cevac Transmune by in ovo or subcutaneous vaccination. The
mixed products protect against Newcastle disease virus, virulent Marek’s disease virus
and very virulent avian Infectious Bursal Disease (IBD) viruses. The safety and efficacy of
the mixed vaccines are not different from those described for the vaccines administered
separately. Read also the product information of Cevac Transmune before use.
In-ovo administration:
One single dose of 0.05 ml is injected into each 18-day-old embryonated broiler chicken
egg.
Match the dose size of the vaccines and the sterile solvent according to the table below.
Vectormune NDCevac TransmuneSterile solvent2 x 2,000 doses2 x 2,000 doses200 ml1 x 4,000 doses1 x 4,000 doses200 ml2 x 4,000 doses2 x 4,000 doses400 ml4 x 4,000 doses4 x 4,000 doses800 ml5 x 4,000 doses5 x 4,000 doses1000 ml6 x 4,000 doses6 x 4,000 doses1200 ml8 x 4,000 doses8 x 4,000 doses1600 ml
Subcutaneous use:
One single injection of 0.2 ml per chick is applied for broilers at one day of age.
Match the dose size of the vaccines and the sterile solvent according to the table below.
Vectormune NDCevac TransmuneSterile solvent2 x 1,000 doses1 x 2,000 doses400 ml1 x 2,000 doses1 x 2,000 doses400 ml2 x 2,000 doses2 x 2,000 doses800 ml1 x 4,000 doses1 x 4,000 doses800 ml4,000 + 1,000 doses4,000 + 1,000 doses1000 ml3 x 2,000 doses3 x 2,000 doses1200 ml2 x 4,000 doses2 x 4,000 doses1600 ml
Draw up 2 ml of sterile solvent into a 5 ml syringe then draw up the thawed content of
Vectormune ND ampoule in it.
Draw up 2 ml of sterile solvent into another 5 ml syringe then dissolve the content of
Cevac Transmune vial in it.
Transfer the dissolved vaccines into the solvent bag and mix by gentle agitation.
Safety and efficacy data are available which demonstrate that this vaccine can be mixed
and administered with Cevac MD Rispens by subcutaneous application. Read also the
product information of Cevac MD Rispens before use.

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AN: 00764/2024 Page 4 of 8
Overview table for recommended dilution possibilities of different presentations in case
of associated use:
No. of ampoules x doses (D)
Cevac MD RispensVectormune ND
Solvent
presentation
(ml)
Volume of one
dose
(ml)
1 x 1,000 D1 x 1,000 D2001 x 2,000 D1 x 2,000 D4002 x 2,000 D2 x 2,000 D8001 x 4,000 D1 x 4,000 D8004000 + 1000 D4000 + 1000 D10003 x 2000 D3 x 2000 D12002 x 4000 D2 x 4000 D1600
0.20
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product, except Cevac Transmune and Cevac MD Rispens
(where it is marketed). A decision to use this vaccine before or after any other veterinary
medicinal product therefore needs to be made on a case by case basis.

Suspension:
Store and transport frozen in liquid nitrogen (-196 °C).
The liquid nitrogen containers must be checked regularly for liquid nitrogen level and
must be refilled as needed.
Solvent:
Store below 25 °C.
Do not freeze.

already containing 2 ml of solvent with a needle of at least 18 gauge diameter.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.