POM-V Prescription Required

Innovax-ND-H5 Concentrate and Solvent for Suspension for Injection for Chickens

Active ingredient: Turkey herpesvirus

Form

Injection

Species

Chicken embryonated eggs Chickens

Manufacturer

MSD Animal Health UK Limited

VMD MA No.

01708/5131

What it's used for

Onset of immunity: MD – 5 days, ND 4 – weeks and HPAI H5 – 2 weeks. Duration of immunity: MD lifelong, ND and HPAI – 12 weeks For HPAI: duration of immunit...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Turkey herpesvirus

1

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2

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Prescription required

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Clinical information

Innovax-ND-H5 Concentrate and Solvent for Suspension for Injection for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: MD – 5 days, ND 4 – weeks and HPAI H5 – 2 weeks.
Duration of immunity: MD lifelong, ND and HPAI – 12 weeks
For HPAI: duration of immunity (reduction of mortality and clinical signs
demonstrated) with in ovo administration.

In ovo use: one single injection of 0.05 ml per chicken egg.
Preparation of the vaccine:
The usual aseptic precautions should be applied to all preparation and administration
procedures. The handling of liquid nitrogen should take place in a well-ventilated
area.
1. Use solvent for cell associated poultry vaccines for reconstitution.
For subcutaneous use reconstitute the vaccine according to the table below:
Solvent bag
Number of vaccine ampoules for
subcutaneous use
Bag of 400 ml
solvent
1 ampoule containing 2,000 doses
Bag of 800 ml
solvent
2 ampoules containing 2,000 doses
Bag of 800 ml
solvent
1 ampoule containing 4,000 doses
Bag of 1,200 ml
solvent
3 ampoules containing 2,000 doses
Bag of 1,600 ml
solvent
4 ampoules containing 2,000 doses
Bag of 1,600 ml
solvent
2 ampoules containing 4,000 doses
When this product is mixed with Nobilis Rismavac, both should be diluted in the
same solvent bag in the same way (400 ml of solvent for each 2,000 doses of
both products or 800 ml of solvent for each 4,000 doses of both products).
For in ovo use reconstitute the vaccine according to the table below:
Solvent bag
Number of vaccine ampoules for in ovo
use
Bag of 400 ml solvent4 ampoules containing 2,000 dosesBag of 400 ml solvent2 ampoules containing 4,000 dosesBag of 800 ml solvent8 ampoules containing 2,000 dosesBag of 800 ml solvent4 ampoules containing 4,000 dosesBag of 1,200 ml solvent12 ampoules containing 2,000 dosesBag of 1,200 ml solvent6 ampoules containing 4,000 dosesBag of 1,600 ml solvent16 ampoules containing 2,000 dosesBag of 1,600 ml solvent8 ampoules containing 4,000 doses
The solvent must be clear, red coloured, without sediment and at room
temperature (15 °C – 25 °C) at the time of mixing.
2. Preparation of the vaccine shall be planned before the ampoules are taken from
the liquid nitrogen and the exact amount of vaccine ampoules and amount of
solvent needed shall be calculated first. There is no information available on the
number of doses on the ampoules once they are removed from the cane, so
special care has to be taken to ensure that the mix-ups of ampoules with
different number of doses is avoided and the correct solvent is used.
3. Before withdrawing the ampoules from the liquid nitrogen container, protect the
hands with gloves, wear long sleeves and use a facemask or goggles. When
removing an ampoule from the cane, hold in the palm of a gloved hand away
from the body and the face.
4. When withdrawing a cane of ampoules from the canister in the liquid nitrogen
container, expose only the ampoule(s) to be used immediately. It is
recommended to handle a maximum of 5 ampoules (from one cane only) at a
time. After removing the ampoule(s), the remaining ampoules should be put
back immediately into the canister in the liquid nitrogen container.
5. Thaw the content of the ampoule(s) rapidly by immersing the ampoule in clean
water at 25 °C – 27 °C. Gently swirl the ampoule(s) to disperse the contents. In
order to protect the cells, it is important that the ampoule content is mixed,
immediately after thawing, with the solvent.
Dry the ampoule, then break the ampoule at its neck and immediately proceed
as described below.
6. Gently withdraw the contents of the ampoule into a sterile syringe fitted with an
18-gauge needle.
7. Insert the needle through the stopper of the solvent bag, and then slowly and
gently add the contents of the syringe to the solvent. Gently swirl and invert the
bag to mix the vaccine. Withdraw a small quantity from the solvent bag into the
syringe and rinse the ampoule. Inject the remaining contents of the ampoule
gently into the solvent bag.
8. Repeat steps 6 and 7 for additional ampoules, if required.
9. Remove the syringe and invert the bag (6–8 times) to mix the vaccine.
10. The vaccine is now ready for use.
After adding the contents of the ampoule to the solvent, the ready to use
product is a clear, red coloured suspension for injection.
Administration:
The vaccine is administered by subcutaneous injection in the neck or by
injection. The bag of vaccine should be gently swirled frequently during vaccination to
guarantee that the vaccine suspension remains homogenous and that the correct
vaccine virus titre is administered (e.g., during long vaccination sessions).
Control of correct storage:
To allow a check on correct storage and transport the ampoules are placed upside
down in the liquid nitrogen containers. If frozen content is situated in the tip of the
ampoule this indicates that the content has been thawed and must not be used.

None.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.
Maternally derived antibodies (against HPAI H5) can interfere with efficacy of the
vaccine.

Special precautions for safe use in the target species:
As this is a live vaccine, the vaccine strain is excreted from vaccinated birds and may
spread to turkeys. Safety trials have shown that the strain is safe for turkeys.
However, precautionary measures have to be followed in order to avoid direct or
indirect contact between vaccinated chickens and turkeys.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
The handling of liquid nitrogen should take place in a well-ventilated area.
Innovax-ND-H5 is a virus suspension packed in glass ampoules and stored in liquid
nitrogen. Before withdrawing ampoules from the liquid nitrogen canister, personal
protective equipment consisting of gloves, long sleeves and a facemask or goggles
should be worn when handling the veterinary medicinal product. In order to prevent
serious wounds, by either the liquid nitrogen or the ampoules when removing an
ampoule from the canister, hold the palm of the (gloved) hand holding the ampoule
away from the body and face. Care should be exercised to prevent contaminating the
hands, eyes and clothing with the ampoule content.
CAUTION: The ampoules have been known to explode on exposure to sudden
temperature changes. Do not thaw in hot water or ice-cold water. Thaw the ampoules
in clean water at 25 °C – 27 °C.
Special precautions for the protection of the environment:
Not applicable.

Safety data are available which demonstrate that Innovax-ND-H5 can be mixed in the
same solvent and administered by the subcutaneous route use with Nobilis
Rismavac.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product except the product mentioned above. A
decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case by case basis, taken into consideration the
information in section 4.1.

Concentrate:
Store and transport frozen in liquid nitrogen (below -140 °C).
Solvent:
Store below 30 °C.
Container:
Store liquid nitrogen container securely in an upright position in a clean, dry and well-
ventilated room separated from the hatching/chicken room.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.