Topimec Plus 10/100 mg/ml Solution for Injection for Cattle

Care should be taken to avoid the following practices because they increase the risk of
development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using
appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s)
strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to
another pharmacological class and having a different mode of action should be used.
Resistance to Ivermectin has been reported in Ostertagia ostertagi and Cooperia species
in cattle within the EU. Therefore, the use of this product should be based on local
(regional, farm) epidemiological information about susceptibility of these helminth species
and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for safe use in the target species:
This product does not contain any antimicrobial preservative. Swab septum before
removing each dose.
To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or
the spine, it is recommended to administer the product at the end of the period of fly
activity and before the larvae reach their resting sites: seek professional advice on the
correct timing of treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Do not smoke, eat, or drink whilst handling the product. Wash hands after use. Direct
contact with the skin should be avoided. Wear gloves and glasses when handling the
veterinary medicinal product. Take care to avoid self-injection: the product may cause
local irritation and/or pain at the injection site. In case of accidental self-injection, seek
medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
The product is very toxic to aquatic organisms and dung insects. Treated cattle should not
have direct access to ponds, streams, or ditches for 14 days after treatment. Long term
effects on dung insects caused by continuous or repeated use cannot be excluded.
Therefore, repeated treatments on a pasture within a season should only be given on the
advice of a veterinarian.