Tilmicosol 250 mg/ml Solution for Use in Drinking Water/Milk

In drinking water/milk use
The product must be diluted in drinking water (pigs, chickens, turkeys) or milk replacer
(calves) before administration.
Calves: 12.5 mg tilmicosin/kg body weight (i.e.1 ml of product per 20 kg body weight),
twice daily, for 3-5 consecutive days.
Pigs: 15-20 mg tilmicosin/kg body weight/day (i.e. 6-8 ml of product per 100 kg of body
weight per day), for 5 consecutive days, which may be achieved by the inclusion of 150-
200 mg of tilmicosin per litre (60-80 ml of product per 100 litres based on a water
consumption of 10 % of bodyweight).
Chickens: 15-20 mg tilmicosin/kg body weight/day (i.e. 6-8 ml of product per 100 kg of
body weight per day), for 3 consecutive days, which may achieved by the inclusion of 75-
100 mg of tilmicosin per litre (30-40 ml of product per 100 litres
consumption of 20 % of bodyweight).
Turkeys: 10-27 mg tilmicosin/kg body weight/day (i.e. 4-11 ml of product per 100 kg of
body weight per day), for 3 consecutive days, which may achieved by the inclusion of 143-
386 mg of tilmicosin per litre (57-154 ml of product per 100 litres
consumption of 7 % of bodyweight).
If signs of disease do not significantly improve within 3-5 days, the diagnosis should be re-
evaluated and treatment changed.
The exact concentration of the veterinary medicinal product required can be calculated
according to the following formula:
ml product per litre drinking water per day = [ml product per kg bodyweight per day x
average bodyweight (kg)] / average daily water intake (litre).
Bodyweight should be determined as accurately as possible to avoid under-dosing. The
required dose should be measured using suitably calibrated measuring equipment. Only
sufficient medicated drinking water should be prepared to cover the daily requirements.

Revised: November 2023
AN: 01156/2023 & 01157/2023Page 4 of 7
The medicated water should be the only source of drinking water for the animals for the
entire duration of the treatment period. Water intake should be monitored at frequent
intervals during medication. After the end of the medication period, the water supply
system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the
active substance.
Medicated drinking water should be prepared fresh every 24 hours. Medicated milk
replacer should be prepared fresh every 6 hours.
The medicinal product should be diluted with water or milk replacer prior to its use. When
preparing a stock solution, the maximum concentration should not exceed 200 ml of
product/litre. The lowest concentrations of the product at which stability can be assured
are 0.3 ml product/litre drinking water and 0.8 ml product/litre milk replacer.
The uptake of medicated drinking water/milk replacer depends on the clinical condition of
the animals. In order to obtain the correct dosage, the concentration of the product should
be adjusted accordingly.