POM-V Prescription Required

Hymatil 300 mg/ml Solution for Injection for Cattle and Sheep

Active ingredient: Tilmicosin

Form

Injection

Species

Cattle Sheep

Manufacturer

Industrial Veterinaria SA

VMD MA No.

36547/4000

What it's used for

Treatment of interdigital necrobacillosis. AN: 01033/2024 & 01037/2024 Sheep: Treatment of respiratory tract infections caused by and Pasteurella multocida...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Tilmicosin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Hymatil 300 mg/ml Solution for Injection for Cattle and Sheep — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of interdigital necrobacillosis.
AN: 01033/2024 & 01037/2024
Sheep:
Treatment of respiratory tract infections caused by
and Pasteurella multocida.
Treatment of foot rot in sheep caused by and
Fusobacterium necrophorum.
Treatment of acute ovine mastitis caused by and
Mycoplasma agalactiae.

To ensure a correct dosage, body weight should be determined as
accurately as possible.
Cattle:
Method of administration:
Withdraw the required dose from the vial and remove the syringe from the
needle, leaving the needle in the vial. When a group of animals has to be
treated, leave the needle in the vial to remove the subsequent doses.
Restrain the animal and insert separate needle subcutaneously at the
injection site, preferably in a skinfold over the rib cage behind the shoulder.
Attach the syringe to the needle and inject into the base of the skinfold. Do
not inject more than 20 ml per injection site.
Sheep:
Method of administration:
The use of a 2 ml syringe or smaller improves accurate dosing.
Withdraw the required dose from the vial and remove the syringe from the
needle, leaving the needle in the vial. Restrain the sheep whilst leaning over
the animal and insert a separate needle subcutaneously into the injection
site, which should be in a skinfold over the rib cage behind the shoulder.
Attach the syringe to the needle and inject into the base of the skin fold. Do
not inject more than 2 ml per injection site.
If no improvement is noted within 48 hours, the diagnosis should be
confirmed.
Avoid introduction of contamination into vial during use. The vial should be
inspected visually for any foreign particulate matter and/or abnormal
physical appearance. In the event of either being observed, discard the vial.

Do not use intravenously.
Do not use intramuscularly.
Do not use in lambs weighing less than 15 kg.
Do not use in primates.
Do not use in pigs.
Do not use in horses and donkeys.
Do not use in goats.
Do not use in cases of hypersensitivity to the active substance or to any of
the excipients.

Cattle and sheep:
Rare
(1 to 10 animals / 10,000
animals treated):
Recumbency
Incoordination, convulsion
Undetermined frequency
(cannot be estimated from the
available data)
Injection site swelling
Death
¹Soft and diffuse. Disappears within five to eight days.
Deaths of cattle have been observed following a single intravenous dose of
5 mg/kg body weight, and following the subcutaneous injection of doses of
150 mg/kg body weight at 72 hour intervals. Sheep have died following a
single intravenous injection of 7.5 mg/kg body weight
Reporting adverse events is important. It allows continuous safety
monitoring of a veterinary medicinal product. Reports should be sent,
preferably via a veterinarian, to either the marketing authorisation holder or
its local representative or the national competent authority via the national
reporting system. See the package leaflet for respective contact details.

Sheep
The clinical trials did not demonstrate a bacteriological cure in sheep with
acute mastitis caused by and
agalactiae.
Do not administer to lambs weighing less than 15 kg since there is a risk of
overdose toxicity.
Accurate weighing of lambs is important to avoid overdose. The use of a 2
ml or smaller syringe will facilitate accurate dosing.

Special precautions for safe use in the target species:
Official, national and regional antimicrobial policies should be taken into
account when the veterinary medicinal product is used.
To avoid self-injection do not use automatic injection equipment.
Wherever possible, the use of the veterinary medicinal product should be
based on susceptibility testing.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Operator Safety Warnings:
AN: 01033/2024 & 01037/2024
INJECTION OF TILMICOSIN IN HUMANS CAN BE FATAL – EXERCISE
EXTREME CAUTION TO AVOID ACCIDENTAL SELF INJECTION AND
FOLLOW THE ADMINISTRATION INSTRUCTIONS AND THE
GUIDANCE BELOW, PRECISELY
•
veterinary surgeon.
•
needle should be connected to the syringe only when filling the syringe or
administering the injection. Keep the syringe and needle separate at all
other times.
•
•
•
In case of self-injection SEEK IMMEDIATE MEDICAL ATTENTION and take
the vial or the package leaflet with you. Apply a cold pack (not ice directly) to
the injection site.
Additional operator safety warnings:
•
immediately with water.
•
NOTE TO THE PHYSICIAN
INJECTION OF TILMICOSIN IN HUMANS HAS BEEN ASSOCIATED WITH
FATALITIES.
The cardiovascular system is the target of toxicity, and this toxicity may be
due to calcium channel blockade. Administration of intravenous calcium
chloride should only be considered if there is positive confirmation of
exposure to tilmicosin.
In dog studies, tilmicosin induced a negative inotropic effect with consequent
tachycardia, and a reduction in systemic arterial blood pressure and arterial
pulse pressure.
Do not give adrenalin
propranolol.
In pigs, tilmicosin-induced lethality is potentiated by adrenalin.
In dogs, treatment with intravenous calcium chloride showed a positive effect
on the left ventricular inotropic state and some improvements in vascular
blood pressure and tachycardia.
Pre-clinical data and an isolated clinical report suggest that calcium chloride
infusion may help to reverse tilmicosin induced changes in blood pressure
and heart rate in humans.
Administration of dobutamine should also be considered due to its positive
inotropic effects although it does not influence tachycardia.
As tilmicosin persists in tissues for several days, the cardiovascular system
should be closely monitored and supportive treatment provided.
AN: 01033/2024 & 01037/2024
Physicians treating patients exposed to this compound are advised to
discuss clinical management with the National Poisons Information Service
on: (indicate here the telephone number of the centre).
Special precautions for the protection of the environment:
Not applicable.

interaction
Interactions between macrolides and ionophores could be observed in some
species.
AN: 01033/2024 & 01037/2024

Store below 25ºC.
Keep the vial in the outer carton in order to protect from light.
Do not freeze.

Cattle:
Meat and offal: 70 days.
Milk: 36 days.
If the veterinary medicinal product is administered to cows during the dry
period or to pregnant dairy heifers (in accordance with section 3.7 above),
milk should not be used for human consumption until 36 days after calving.
Sheep:
Meat and offal: 42 days.
Milk: 18 days.
If the veterinary medicinal product is administered to ewes during the dry
period or to pregnant ewes (in accordance with section 3.7 above), milk
should not be used for human consumption until 18 days after lambing.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.