Seresto Flea and Tick Control 4.50 g + 2.03 g, Collar for Large Dogs > 8 kg
Active ingredients: Flumethrin, Imidacloprid
Form
Collar
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/5107
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Seresto Flea and Tick Control 4.50 g + 2.03 g, Collar for Large Dogs > 8 kg — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Protects the animal’s immediate surroundings against flea larvae development for 8
months.
The veterinary medicinal product can be used as part of a treatment strategy for the
control of Flea Allergy Dermatitis (FAD), where this has been previously diagnosed
by a veterinary surgeon.
The veterinary medicinal product has persistent acaricidal (killing) efficacy against
tick infestations (Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus)
and repellent (anti-feeding) efficacy against tick infestations (Ixodes ricinus,
Rhipicephalus sanguineus) for 8 months. It is effective against larvae, nymphs and
adult ticks.
Ticks already on the dog prior to treatment may not be killed within 48 hours after
collar application and may remain attached and visible. Therefore, removal of ticks
already on the dog at the time of application is recommended. If you are unsure how
to safely remove ticks from your animal, seek professional guidance. The prevention
of infestations with new ticks starts within two days after application of the collar.
The veterinary medicinal product provides indirect protection against the transmission
of the pathogens Babesia canis vogeli and Ehrlichia canis from the tick vector
Rhipicephalus sanguineus, thereby reducing the risk of canine babesiosis and canine
ehrlichiosis for 7 months.
For treatment of biting/chewing lice (Trichodectes canis) infestation.
For external use only.
Remove collar from protective bag directly before use. Unroll collar and make sure
that there are no remnants from the plastic connectors inside the collar. Adjust the
collar around the animal's neck without tightening it too tight (as a guide, it should be
possible to insert 2 fingers between the collar and the neck). Pull excess collar
through the loop and cut off any excess length extending beyond 2 cm.
The collar should be worn continuously for the 8 month protection period and should
be removed after the treatment period. Check periodically and adjust fit if necessary,
especially when puppies are rapidly growing.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Rare
(1 to 10 animals / 10,000
animals treated):
Application site disorders
(e.g. Erythema, Hair
loss, Pruritus)
Behavioural disorder
(e.g. Scratching)
Diarrhoea
, Hypersalivation
, Vomiting
Ataxia
, Convulsion
, Tremor
Appetite disorder
, Depression
Very rare
(< 1 animal / 10,000 animals
treated, including isolated
reports):
Application site disorders
(e.g. Dermatitis,
Eczema, Inflammation, Lesion)
Hypersensitivity reaction (e.g. Contact dermatitis)
Anorexia, Lethargy
Signs usually resolve within 1 to 2 weeks. In single cases, temporary collar removal
is recommended until signs resolve.
May be observed in animals that are not used to wearing collars on the first few
days after fitting. Ensure that collar is fitted correctly.
Slight and transient reactions that might occur with initial use.
In these cases, collar removal is recommended.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
having had a blood meal, as a rule. An attachment of single ticks after treatment
cannot be excluded. For this reason, a transmission of infectious diseases by ticks
cannot be completely excluded if conditions are unfavourable.
Ideally, the collar should be applied before the beginning of the flea or tick season.
As with all long-term topical veterinary medicinal products, periods of excessive
seasonal hair shedding may lead to transient slight reduction of efficacy by loss of
hair-bound portions of the active ingredients. Replenishment from the collar starts
immediately so that full efficacy will be re-established without any additional
treatment or collar replacement. For optimum control of flea problems in heavily
infested households it may be necessary to treat the environment with a suitable
insecticide.
The veterinary medicinal product is water resistant; it remains effective if the animal
becomes wet. However, prolonged, intense exposure to water or extensive
shampooing should be avoided as the duration of activity may be reduced. Studies
show that monthly shampooing or water immersion does not significantly shorten the
8 months efficacy duration for ticks after redistribution of the active substances in the
coat whereas the veterinary medicinal product’s flea efficacy gradually decreased,
starting in the 5th month.
Special precautions for safe use in the target species:
Do not allow animals to chew the collar.
Ensure that the collar is fitted correctly (see section 3.9)
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
The product may cause hypersensitivity (allergic) reactions in some people. People
with known hypersensitivity to imidacloprid or flumethrin should avoid contact with the
product.
Numbness, headache, and dizziness, have been reported after contact with the collar
or with treated animals. Skin, eye, and respiratory tract irritation have been reported
in very rare cases.
Do not allow children to play with the collar, particularly sucking it or putting it into
their mouths.
Do not sleep with pets wearing collars, especially children. Imidacloprid and
flumethrin are continuously released from the collar to the skin and fur whilst the
collar is being worn.
In case of eye contact, flush eyes thoroughly with cold water. In case of skin contact,
wash the skin with soap and cold water.
If you develop any of these symptoms, or they persist over time, seek medical advice
and show the package leaflet or the label to the physician.
Keep the bag with the collar in the outer packaging until use.
Immediately dispose of any remnants or off-cuts of the collar (see section 4.9).
Wash hands with cold water after fitting the collar.
Special precautions for the protection of the environment:
See section 5.5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Flumethrin
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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