Prevexto 4.50 g + 2.03 g, Medicated Collar for Dogs over 8 kg

Ticks already on the dog prior to treatment may not be killed within 48 hours after collar
application and may remain attached and visible. Therefore removal of ticks already
on the dog at the time of application is recommended. If you are unsure how to safely
remove ticks from your animal, seek professional guidance. The prevention of
infestations with new ticks starts within two days after application of the collar.
Ticks will be killed and fall off the host within 24 to 48 hours after infestation without
having had a blood meal, as a rule. An attachment of single ticks after treatment cannot
be excluded. For this reason, a transmission of infectious diseases by ticks cannot be
completely excluded if conditions are unfavourable.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy. The
decision to use the product should be based on confirmation of the parasitic species
and burden, or of the risk of infestation based on its epidemiological features, for each
individual.
The use of this product should take into account local information about susceptibility
of the target parasites, where available.
In the absence of risk of co-infestation by fleas, ticks, and lice a narrow spectrum
product should be used.
Although a significant reduction in the incidence of in dogs has
been demonstrated, the product has shown variable repellent (anti-feeding) and
insecticidal efficacy against the sand fly . As a result, bites by
sand flies may occur, and the transmission of
completely excluded. The collar should be applied just before the beginning of the
period of activity of sand fly vectors corresponding to the
transmission season and worn continuously throughout the risk period.
Ideally, the collar should be applied before the beginning of the flea or tick season.
As in all long-term topical products, periods of excessive seasonal hair shedding may
lead to transient slight reduction of efficacy by loss of hair-bound portions of the active
ingredients. Replenishment from the collar starts immediately so that full efficacy will
be re-established without any additional treatment or collar replacement.
For optimum control of flea problems in heavily infested households it may be
necessary to treat the environment with a suitable insecticide.
Fleas can infest pets’ beds, sleeping areas and usual resting areas like rugs and sofas.
In the event of a massive infestation, these places should be treated with a suitable
insecticide and vacuumed regularly.
The possibility that other animals in the same household can be a source of re-
infestation with fleas, ticks or lice should be considered, and these should be treated
as necessary with an appropriate product
The veterinary medicinal product is water resistant; it remains effective if the animal
becomes wet. However, shampooing or prolonged, intense exposure to water should
be avoided as the duration of activity may be reduced.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Accidental ingestion of the veterinary medicinal product can induce adverse effects,
including neurotoxic effects.
Avoid oral exposure or accidental ingestion, especially by children.

Keep the sachet with the collar in the outer packaging until use and keep the collar in
the sachet until use.
Do not allow small children to play with the collar, or to put it into their mouth.
Immediately dispose of any remnants or cut-offs of the collar (see sections 3.9 and
5.5).
In case of oral exposure or accidental ingestion, seek immediate medical advice and
show the package leaflet or the label to the physician.

The veterinary medicinal product may cause hypersensitivity reactions in some people.
People with known hypersensitivity (allergy) to the ingredients of the collar, or iron
oxides, should avoid contact with the veterinary medicinal product and the treated
animal.
In case of hypersensitive reactions seek medical advice and show the package leaflet
or the label to the physician.
The veterinary medicinal product may cause skin, eye and respiratory irritation in some
people in very rare cases.
Avoid eye and skin contacts.
In case of eye irritation, flush eyes thoroughly with cold water.
In case of skin irritation, wash the skin with soap and cold water.
If symptoms persist it is recommended to seek medical advice and show the package
leaflet or the label to the physician.
Imidacloprid and flumethrin are continuously released from the collar to the skin and
fur whilst the collar is being worn.
Avoid prolonged contact with the collar when placing it on the animal and also when it
is worn by the treated animal. This especially applies to pregnant women.
Wash hands with cold water after fitting the collar.
Pets wearing the collar should not be allowed to sleep in the same bed as their owners,
especially children.
Special precautions for the protection of the environment:
Imidacloprid and flumethrin may adversely affect aquatic organisms. Dogs wearing the
collar should not be allowed to swim in water courses.
Imidacloprid containing products are toxic to honey bees.