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AVM-GSL Over the Counter Companion Animal

RSPCA FLEAaway Combo 268 mg/ 241.2 mg Spot-on Solution for Large Dogs

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/3011

What it's used for

To be used against infestations with fleas, alone or in association with ticks and/or biting lice. Treatment of flea infestations (Ctenocephalides spp.). I...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for (S)-Methoprene + Fipronil

  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

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    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

RSPCA FLEAaway Combo 268 mg/ 241.2 mg Spot-on Solution for Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persists for 8 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for eight weeks after
application.
Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor
reticulatus, Rhipicephalus sanguineus). The product has persistent acaricidal efficacy
for up to 4 weeks against ticks.
Treatment of infestations with biting lice (Trichodectes canis).
Route of administration and dosage:
External use only.
Administer by topical application to the skin; one pipette of 2.68 ml (268 mg fipronil +
241.2 mg S-methoprene) per dog weighing over 20 kg and up to 40 kg.
This corresponds to a minimum recommended dose of 6.7 mg/kg for fipronil and 6
mg/kg for S-methoprene, by topical application to the skin.
In the absence of safety studies the minimum treatment interval is 4 weeks.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible.
4. Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
Do not use on puppies less than 8 weeks old.

Revised: September 2023
AN: 03316/2022
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use if your dog has a hypersensitivity to fipronil or S-methoprene or the other
ingredients.
Do not apply on wounds or damaged skin.
Do not use in cats and ferrets, as this could lead to overdosing.
Do not use on rabbits as adverse drug reactions, including death, may occur.
Do not use in any other non-target species.
Dog:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site skin discoloration, hair loss,
itching, reddening*
Generalised itching or hair loss
Undetermined frequency
(cannot be estimated from the
available data)
Increased salivation
Vomiting
Increased sensitivity to stimulation, depression,
other nervous signs
Respiratory signs
*Transient.
In the case of licking the administration site, a brief period of excessive salivation
may be observed due mainly to the nature of the carrier.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the last section of the package leaflet for contact
details.
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time. Fleas from pets often infest the animal's
basket, bedding and regular resting areas such as carpets and soft furnishings which
should be treated, in case of massive infestation and at the beginning of the control
measures, with a suitable insecticide and vacuumed regularly.

i) Special precautions for use in animals
Avoid contact with the animal's eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
People with a known hypersensitivity (allergy) to fipronil, S-methoprene, or alcohol
should avoid contact with the product. Avoid contents coming into contact with the
fingers. If the product comes into contact with fingers, wash hands with soap and
water.
After accidental eye contact, rinse carefully with clean water.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet or the label to the doctor.
Wash hands after use.

Revised: September 2023
AN: 03316/2022
Do not smoke, drink or eat during application.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Keep pipettes in original packaging until ready to use and dispose of used pipettes
immediately.
iii) Other precautions
Dogs should not be allowed to swim in watercourses for 2 days after application (see
section 6.6).
Do not use simultaneously with other flea products which are applied directly on to
the animal.

Revised: September 2023
AN: 03316/2022
This veterinary medicinal product does not require any special temperature storage
conditions. Store in the original package in order to protect from light and moisture.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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