POM-V
Prescription Required
Rispoval IBR-Marker Live Lyophilisate and Diluent for Suspension for Injection for Cattle
Active ingredient: Infectious bovine rhinotraceitis virus
Form
Injection
Species
Cattle
Manufacturer
Zoetis Belgium S.A.
VMD MA No.
60021/3046
What it's used for
demonstrated during the second trimester of gestation upon challenge 28 days after vaccination. Vaccinated cattle can be differentiated from field virus in...
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Clinical information
Rispoval IBR-Marker Live Lyophilisate and Diluent for Suspension for Injection for Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
demonstrated during the second trimester of gestation upon challenge 28 days after
vaccination. Vaccinated cattle can be differentiated from field virus infected animals due to
AN: 03156/2024Page 2 of 9
the marker deletion, unless the cattle were previously vaccinated with a conventional
vaccine or infected with field virus.
Onset of immunity: 7 days following a single intranasal administration.
21 days following a single intramuscular administration.
Duration of immunity following vaccination before 3 months of age: after intranasal
vaccination of calves aged 2 weeks or older without maternally derived antibodies,
immunity lasts until at least 3 months of age, when the animals should be revaccinated via
intramuscular injection.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which
may affect the immune response to vaccination. Consequently, the protection afforded by
the vaccine may not be complete until the revaccination at 3 months of age.Duration of
immunity following vaccination at or after 3 months of age: 6 months.
Additional information on protection from abortion afforded by combined
vaccination of Rispoval IBR-Marker Vivum with Rispoval IBR-Marker Inactivatum*:
prevention of abortion has been demonstrated during the third trimester of gestation upon
BoHV-1 challenge applied 86 days after a single dose booster vaccination using Rispoval
IBR-Marker Inactivatum*, which was administered 6 months after a single dose primary
vaccination by the intramuscular route using Rispoval IBR-Marker Vivum.
Where this veterinary medicinal product is authorised.
vaccination. Vaccinated cattle can be differentiated from field virus infected animals due to
AN: 03156/2024Page 2 of 9
the marker deletion, unless the cattle were previously vaccinated with a conventional
vaccine or infected with field virus.
Onset of immunity: 7 days following a single intranasal administration.
21 days following a single intramuscular administration.
Duration of immunity following vaccination before 3 months of age: after intranasal
vaccination of calves aged 2 weeks or older without maternally derived antibodies,
immunity lasts until at least 3 months of age, when the animals should be revaccinated via
intramuscular injection.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which
may affect the immune response to vaccination. Consequently, the protection afforded by
the vaccine may not be complete until the revaccination at 3 months of age.Duration of
immunity following vaccination at or after 3 months of age: 6 months.
Additional information on protection from abortion afforded by combined
vaccination of Rispoval IBR-Marker Vivum with Rispoval IBR-Marker Inactivatum*:
prevention of abortion has been demonstrated during the third trimester of gestation upon
BoHV-1 challenge applied 86 days after a single dose booster vaccination using Rispoval
IBR-Marker Inactivatum*, which was administered 6 months after a single dose primary
vaccination by the intramuscular route using Rispoval IBR-Marker Vivum.
Where this veterinary medicinal product is authorised.
After reconstitution, the suspension should be a colourless clear liquid, which might
contain a loose resuspendable sediment.
The vaccination scheme consists of basic immunisation and booster vaccinations.
Basic immunisation:
Calves of 2 weeks to 3 months of age at first vaccination
The first vaccination should be applied intranasally, followed by a second vaccination
intramuscularly at 3 months of age.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which
may affect the immune response to vaccination. Consequently, the protection afforded by
the vaccine may not be complete until the revaccination at 3 months of age.As an extra
precaution in situations of high challenge with BoHV-1, maternal antibody positive animals
that have been initially vaccinated at around 2 weeks of age may be given an additional
vaccination between the first vaccination and vaccination at 3 months of age.
This additional vaccination may be given via either intranasal or intramuscular
administration and may be given from 3 weeks after the first vaccination.
Cattle at 3 months of age or older at first vaccination
Animals should be given one intramuscular or intranasal vaccination.
Beef cattle and fattening bulls are vaccinated preferably just prior to housing (crowding) or
at transfer to new groups, while taking into account the interval needed for the onset of
protection following the basic vaccination scheme.
For female cattle for protection against abortion
To prevent abortions associated with BoHV-1, female cattle require a primary course of
two intramuscular doses of Rispoval IBR-Marker Vivum 3-5 weeks apart or alternatively a
primary course of a single intramuscular dose of Rispoval IBR-Marker Vivum followed 6
months later by a single dose booster using Rispoval IBR-Marker Inactivatum*. In order to
cover the main abortion risk period, it is recommended that the second dose of the primary
course of two intramuscular doses of Rispoval IBR-Marker Vivum or the single dose
booster using Rispoval IBR-Marker Inactivatum* is administered no later than by the start
of the second trimester of each pregnancy.
Cattle at immediate risk of IBR
In the case of known high BoHV-1 infection pressure, the first dose in cattle (including
pregnant females) should be administered intranasally in order to stimulate local immunity,
AN: 03156/2024Page 5 of 9
followed 3 – 5 weeks later by the second dose administered intramuscularly to complete
the primary vaccination course.
Booster vaccinations:
Animals should be given a single dose booster vaccination 6 months after their initial
vaccination course. Animals initially vaccinated with Rispoval IBR-Marker Vivum may be
given a single dose booster vaccination with either Rispoval IBR-Marker Vivum to provide
6 months of protection or Rispoval IBR-Marker Inactivatum* to provide a duration of
immunity of 12 months of protection. Thereafter, single dose booster vaccinations should
be administered every 6 months (if using Rispoval IBR-Marker Vivum) or every 12 months
(if using Rispoval IBR-Marker Inactivatum*).
Method of administration:
The freeze-dried pellet should be reconstituted aseptically just prior to use. The vaccine is
prepared as follows:
For 10 and 50 dose vials approx. 4 ml of the respective diluent are transferred to the vial
containing the freeze-dried pellet and then mixed.
The reconstituted virus fraction is finally transferred back into the respective remaining
diluent and mixed well. The veterinary medicinal product is then ready for use.
The needles and syringes used for application of the vaccine must not be sterilised by
chemical disinfectants as this may impair the efficacy of the vaccine.
The vaccine is injected aseptically via the intramuscular route (2 ml) or sprayed into the
nostrils (1 ml per nostril during aspiration) with the intranasal applicator available from
Zoetis. Once resuspended the vaccine remains potent for max. 8 hours when the
veterinary medicinal product is withdrawn sterile and refrigerated.
Vaccination schemes summary:
From 2 weeks to 3 months of age
Rispoval IBR-Marker vaccine usedPrimary VaccinationRevaccination IntervalsFirst dose
(vaccine, route
of
administration)
Second dose
(vaccine, route
of
administration)
Interval to next
booster
vaccination
(vaccine, route of
administration)
All subsequent booster
vaccinations
(vaccine, route of administration)
2 weeks (Vivum,
intranasal)
3 months
(Vivum,
intramuscular)
6 months (Vivum,
intramuscular)
6 months (Vivum, intramuscular)2 weeks (Vivum,
intranasal)
3 months
(Vivum,
intramuscular)
6 months
(Inactivatum*,
subcutaneous)
12 months (Inactivatum*,
subcutaneous)
AN: 03156/2024Page 6 of 9
From 3 months of age
Rispoval IBR-Marker vaccine usedRevaccination Intervals
Primary Vaccination
(number of doses, route of
administration)
Interval to first
booster vaccination
(vaccine, route of
administration)
All subsequent booster
vaccinations
(vaccine, route of
administration)
Vivum (one dose, intramuscular
or intranasal)
6 months (Vivum,
intramuscular)
6 months (Vivum, intramuscular)Vivum (one dose, intramuscular)6 months
(Inactivatum*,
subcutaneous)
12 months (Inactivatum*,
subcutaneous)
Inactivatum* (two doses,
subcutaneous, with 3-5 week
interval)
6 months
(Inactivatum*,
subcutaneous)
6 months (Inactivatum*,
subcutaneous)
For female cattle for protection against abortion:
Rispoval IBR-Marker vaccine used
Primary Vaccination
(number of doses, route of
administration) recommended to
be applied no later than by the start
of second trimester of pregnancy
Revaccination
Vivum (two doses, intramuscular, with
3-5 weeks interval)
Vivum (one dose, intramuscular)
followed by Inactivatum* (one dose,
subcutaneous), with 6 months interval
Inactivatum* (two doses,
subcutaneous, with 3-5 week interval)
Inactivatum* (one dose, subcutaneous)
recommended to be applied no later than
by the start of the second trimester of
each pregnancy
For vaccination in known high BoHV-1 infection pressure:
Rispoval IBR-Marker vaccine usedRevaccination Intervals
Primary Vaccination
(number of doses, route of
administration)
Interval to first
booster vaccination
(vaccine, route of
administration)
All subsequent
booster vaccinations
(vaccine, route of
administration)
Vivum (one dose, intranasal),
followed by Vivum (one dose,
intramuscular) with 3-5 weeks
interval
6 months (Vivum,
intramuscular, OR
Inactivatum*,
subcutaneous)
6 months (Vivum,
intramuscular) OR 12
months (Inactivatum*,
subcutaneous)
* Where this veterinary medicinal product is authorised.
AN: 03156/2024Page 7 of 9
contain a loose resuspendable sediment.
The vaccination scheme consists of basic immunisation and booster vaccinations.
Basic immunisation:
Calves of 2 weeks to 3 months of age at first vaccination
The first vaccination should be applied intranasally, followed by a second vaccination
intramuscularly at 3 months of age.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which
may affect the immune response to vaccination. Consequently, the protection afforded by
the vaccine may not be complete until the revaccination at 3 months of age.As an extra
precaution in situations of high challenge with BoHV-1, maternal antibody positive animals
that have been initially vaccinated at around 2 weeks of age may be given an additional
vaccination between the first vaccination and vaccination at 3 months of age.
This additional vaccination may be given via either intranasal or intramuscular
administration and may be given from 3 weeks after the first vaccination.
Cattle at 3 months of age or older at first vaccination
Animals should be given one intramuscular or intranasal vaccination.
Beef cattle and fattening bulls are vaccinated preferably just prior to housing (crowding) or
at transfer to new groups, while taking into account the interval needed for the onset of
protection following the basic vaccination scheme.
For female cattle for protection against abortion
To prevent abortions associated with BoHV-1, female cattle require a primary course of
two intramuscular doses of Rispoval IBR-Marker Vivum 3-5 weeks apart or alternatively a
primary course of a single intramuscular dose of Rispoval IBR-Marker Vivum followed 6
months later by a single dose booster using Rispoval IBR-Marker Inactivatum*. In order to
cover the main abortion risk period, it is recommended that the second dose of the primary
course of two intramuscular doses of Rispoval IBR-Marker Vivum or the single dose
booster using Rispoval IBR-Marker Inactivatum* is administered no later than by the start
of the second trimester of each pregnancy.
Cattle at immediate risk of IBR
In the case of known high BoHV-1 infection pressure, the first dose in cattle (including
pregnant females) should be administered intranasally in order to stimulate local immunity,
AN: 03156/2024Page 5 of 9
followed 3 – 5 weeks later by the second dose administered intramuscularly to complete
the primary vaccination course.
Booster vaccinations:
Animals should be given a single dose booster vaccination 6 months after their initial
vaccination course. Animals initially vaccinated with Rispoval IBR-Marker Vivum may be
given a single dose booster vaccination with either Rispoval IBR-Marker Vivum to provide
6 months of protection or Rispoval IBR-Marker Inactivatum* to provide a duration of
immunity of 12 months of protection. Thereafter, single dose booster vaccinations should
be administered every 6 months (if using Rispoval IBR-Marker Vivum) or every 12 months
(if using Rispoval IBR-Marker Inactivatum*).
Method of administration:
The freeze-dried pellet should be reconstituted aseptically just prior to use. The vaccine is
prepared as follows:
For 10 and 50 dose vials approx. 4 ml of the respective diluent are transferred to the vial
containing the freeze-dried pellet and then mixed.
The reconstituted virus fraction is finally transferred back into the respective remaining
diluent and mixed well. The veterinary medicinal product is then ready for use.
The needles and syringes used for application of the vaccine must not be sterilised by
chemical disinfectants as this may impair the efficacy of the vaccine.
The vaccine is injected aseptically via the intramuscular route (2 ml) or sprayed into the
nostrils (1 ml per nostril during aspiration) with the intranasal applicator available from
Zoetis. Once resuspended the vaccine remains potent for max. 8 hours when the
veterinary medicinal product is withdrawn sterile and refrigerated.
Vaccination schemes summary:
From 2 weeks to 3 months of age
Rispoval IBR-Marker vaccine usedPrimary VaccinationRevaccination IntervalsFirst dose
(vaccine, route
of
administration)
Second dose
(vaccine, route
of
administration)
Interval to next
booster
vaccination
(vaccine, route of
administration)
All subsequent booster
vaccinations
(vaccine, route of administration)
2 weeks (Vivum,
intranasal)
3 months
(Vivum,
intramuscular)
6 months (Vivum,
intramuscular)
6 months (Vivum, intramuscular)2 weeks (Vivum,
intranasal)
3 months
(Vivum,
intramuscular)
6 months
(Inactivatum*,
subcutaneous)
12 months (Inactivatum*,
subcutaneous)
AN: 03156/2024Page 6 of 9
From 3 months of age
Rispoval IBR-Marker vaccine usedRevaccination Intervals
Primary Vaccination
(number of doses, route of
administration)
Interval to first
booster vaccination
(vaccine, route of
administration)
All subsequent booster
vaccinations
(vaccine, route of
administration)
Vivum (one dose, intramuscular
or intranasal)
6 months (Vivum,
intramuscular)
6 months (Vivum, intramuscular)Vivum (one dose, intramuscular)6 months
(Inactivatum*,
subcutaneous)
12 months (Inactivatum*,
subcutaneous)
Inactivatum* (two doses,
subcutaneous, with 3-5 week
interval)
6 months
(Inactivatum*,
subcutaneous)
6 months (Inactivatum*,
subcutaneous)
For female cattle for protection against abortion:
Rispoval IBR-Marker vaccine used
Primary Vaccination
(number of doses, route of
administration) recommended to
be applied no later than by the start
of second trimester of pregnancy
Revaccination
Vivum (two doses, intramuscular, with
3-5 weeks interval)
Vivum (one dose, intramuscular)
followed by Inactivatum* (one dose,
subcutaneous), with 6 months interval
Inactivatum* (two doses,
subcutaneous, with 3-5 week interval)
Inactivatum* (one dose, subcutaneous)
recommended to be applied no later than
by the start of the second trimester of
each pregnancy
For vaccination in known high BoHV-1 infection pressure:
Rispoval IBR-Marker vaccine usedRevaccination Intervals
Primary Vaccination
(number of doses, route of
administration)
Interval to first
booster vaccination
(vaccine, route of
administration)
All subsequent
booster vaccinations
(vaccine, route of
administration)
Vivum (one dose, intranasal),
followed by Vivum (one dose,
intramuscular) with 3-5 weeks
interval
6 months (Vivum,
intramuscular, OR
Inactivatum*,
subcutaneous)
6 months (Vivum,
intramuscular) OR 12
months (Inactivatum*,
subcutaneous)
* Where this veterinary medicinal product is authorised.
AN: 03156/2024Page 7 of 9
None.
Cattle:
Rare
(1 to 10 animals / 10,000 animals treated):
Nasal discharge
1Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site swelling
, Hypersensitivity
reaction
1
Slight transient, serous discharge may occur for up to 7 days following intranasal
inoculation.
Transient swelling up to 3 cm which generally subsides within 7 days; when injected
intramuscularly.
Vaccinated animals should be observed for approximately 30 minutes following
immunisation. If such reactions occur, antiallergics should be administered.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Rare
(1 to 10 animals / 10,000 animals treated):
Nasal discharge
1Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site swelling
, Hypersensitivity
reaction
1
Slight transient, serous discharge may occur for up to 7 days following intranasal
inoculation.
Transient swelling up to 3 cm which generally subsides within 7 days; when injected
intramuscularly.
Vaccinated animals should be observed for approximately 30 minutes following
immunisation. If such reactions occur, antiallergics should be administered.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
The presence of maternal antibodies can influence the efficacy of the vaccination.
Therefore it is recommended to ascertain the immune status of calves before vaccination
is started.
Vaccinate healthy animals only.
Special precautions for safe use in the target species:
In some cases, the vaccine virus may be excreted after intranasal administration from
vaccinated animals. After intranasal administration of a 10-fold overdose, the vaccine virus
was detected for up to 9 days after vaccination. In very young calves and in rare cases,
vaccine virus was excreted until day 18 post intramuscular vaccination with a 10-fold
overdose. Exceptional transmission of the virus from intranasally-vaccinated animals to
non-vaccinated in-contact animals may occur due to the nature of the vaccine even though
no verified data available would indicate that spreading of the vaccine virus occurs in a
group of animals.
AN: 03156/2024Page 3 of 9
It is recommended to vaccinate all the cattle in the herd.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Therefore it is recommended to ascertain the immune status of calves before vaccination
is started.
Vaccinate healthy animals only.
Special precautions for safe use in the target species:
In some cases, the vaccine virus may be excreted after intranasal administration from
vaccinated animals. After intranasal administration of a 10-fold overdose, the vaccine virus
was detected for up to 9 days after vaccination. In very young calves and in rare cases,
vaccine virus was excreted until day 18 post intramuscular vaccination with a 10-fold
overdose. Exceptional transmission of the virus from intranasally-vaccinated animals to
non-vaccinated in-contact animals may occur due to the nature of the vaccine even though
no verified data available would indicate that spreading of the vaccine virus occurs in a
group of animals.
AN: 03156/2024Page 3 of 9
It is recommended to vaccinate all the cattle in the herd.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Immunosuppressive substances, i.e. corticosteroids or Bovine Virus Diarrhoea modified
live vaccines, should be avoided in a period of 7 days prior to and after vaccination as this
may impair the development of the immunity.
Interferon sensitive veterinary medicinal products should not be applied intranasally
following 5 days after intranasal vaccination.
AN: 03156/2024Page 4 of 9
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be decided on a case by case basis.
live vaccines, should be avoided in a period of 7 days prior to and after vaccination as this
may impair the development of the immunity.
Interferon sensitive veterinary medicinal products should not be applied intranasally
following 5 days after intranasal vaccination.
AN: 03156/2024Page 4 of 9
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be decided on a case by case basis.
Store in a refrigerator (2 °C – 8 °C).
Do not freeze.
Protect from light.
Do not freeze.
Protect from light.
Zero days.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
Other Products Containing Infectious bovine rhinotraceitis virus
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Bovilis IBR Marker Inac Suspension for Injection for Cattle
POM-VIntervet International B.V.
injection
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Bovilis IBR Marker Live, Lyophilisate and Solvent for Suspension for Cattle
POM-VIntervet International B.V.
drops
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Bovilis IBR Marker Live, Lyophilisate and Solvent for Suspension for Cattle
POM-VIntervet International B.V.
drops
Cattle
Rhinovac IBR Marker live Lyophilisate and Solvent for Suspension for Injection or Nasal Spray for Cattle
POM-VAnimal Health Distributors Limited
injection
Cattle
Rispoval 4
POM-VZoetis Belgium S.A.
injection
Cattle
Rispoval 4
POM-VZoetis UK Limited
injection
Cattle
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