POM-V Prescription Required

Bovilis IBR Marker Live, Lyophilisate and Solvent for Suspension for Cattle

Active ingredient: Infectious bovine rhinotraceitis virus

Form

Drops

Species

Cattle

Manufacturer

Intervet International B.V.

VMD MA No.

06376/5021

What it's used for

Active immunisation of cattle to reduce the intensity and duration of the clinical respiratory signs induced by an infection with BHV-1 and to reduce nasal...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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1

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2

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Prescription required

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Clinical information

Bovilis IBR Marker Live, Lyophilisate and Solvent for Suspension for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Active immunisation of cattle to reduce the intensity and duration of the clinical
respiratory signs induced by an infection with BHV-1 and to reduce nasal excretion
of field virus.
Onset of immunity:
An increase in immunity was demonstrated 4 days after intranasal vaccination and
14 days after intramuscular vaccination of 3 month old seronegative animals.
Duration of immunity:
After intranasal administration to 2 week old calves immunity lasts at least until the
age of 3-4 months. In the presence of maternally derived antibodies, the protection
of the vaccine may not be complete until a second vaccination. This second
vaccination should be administered at 3-4 months of age and will result in protective
immunity that lasts for at least 6 months.
Single intranasal or intramuscular vaccination of 3 month old animals provides
protective immunity (reduction of clinical signs and reduction of viral excretion),

Revised: January 2025
AN: 02579/2024
which was demonstrated via challenge 3 weeks after vaccination. Reduction of viral
excretion is maintained for at least 6 months after single vaccination.
Revaccination to ensure protection after the initial 6 months protection period has
elapsed will result in protective immunity that lasts for 1 year.
Specific information:
No information is available on the efficacy of the vaccine to prevent a latent wild virus
infection or to prevent wild virus re-excretion in the latent carrier.

None.

Cattle:
Common
(1 to 10 animals / 100 animals
treated):
Elevated temperature
, Nasal discharge
.Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction.

Revised: January 2025
AN: 02579/2024
A rise of 1 C may occur up to 5 days post vaccination.
After intranasal vaccination.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Vaccinate healthy animals only.
The presence of maternal antibodies can influence the efficacy of the vaccination.
Therefore, it is recommended to ascertain the immune status of calves before
vaccination is started.

Special precautions for use in animals
After intranasal administration, the vaccine virus can spread to in-contact cattle.
Cattle which need to remain totally free from BHV-1 antibodies should be separated
from intranasally vaccinated animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.

Safety and efficacy data - in cattle from 3 weeks of age onwards - are available
which demonstrate that this vaccine can be administered on the same day but not
mixed with Bovilis Bovipast RSP.
Safety and efficacy data are available which demonstrate that for the intramuscular
revaccination - in cattle from 15 months of age onwards (i.e. those that have
previously been vaccinated separately with Bovilis IBR Marker Live and Bovilis BVD)
- this vaccine can be mixed and administered with Bovilis BVD. The product
literature of Bovilis BVD should be consulted before administration of the mixed
products. The adverse effects observed after administration of one dose or an
overdose of the mixed vaccines are not different from those described for the
vaccines administered separately.
When mixed with Bovilis BVD at revaccination, the demonstrated efficacy claims for
Bovilis IBR Marker Live are as follows:
-
BHV-1 and to reduce nasal excretion of field virus.
-
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product except the products mentioned above. A
decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case by case basis.
Do not use together with immunosuppressive agents.

Revised: January 2025
AN: 02579/2024

Lyophilisate:
Store in a refrigerator (2 C – 8 C).
Do not freeze.
Protect from light.
Solvent:
Store below 25 C if stored independently from the lyophilisate.
Do not freeze.

- 10
7.3
TCID50
**
.
*
gE¯: glycoprotein E negative
**
TCID50: tissue culture infective doses 50%
For the full list of excipients, see section

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.