Proposure 10 mg/ml Emulsion for Injection for Dogs and Cats

The veterinary medicinal product is a stable emulsion.
Do not use if evidence of phase separation remains after gentle shaking.
Prior to use, the veterinary medicinal product should be inspected visually for
absence of visible droplets or extraneous foreign particles or phase separation and
discarded if present.
If the veterinary medicinal product is injected too slowly an adequate plane of
anaesthesia may not be achieved due to failure to reach the appropriate threshold of
pharmacological activity.

Special precautions for safe use in the target species:
During induction of anaesthesia, mild hypotension and transient apnoea may occur.
If the veterinary medicinal product is injected too rapidly, cardiopulmonary depression
may occur (apnoea, bradycardia, hypotension).
When using the veterinary medicinal product, facilities for the maintenance of a
patent airway, artificial ventilation and oxygen enrichment must be available.
Following induction of anaesthesia, the use of an endotracheal tube is
recommended. It is advisable to administer supplemental oxygen during maintenance
of anaesthesia.
Caution should be exercised in dogs and cats with cardiac, respiratory, renal or
hepatic impairment, in hypovolaemic, emaciated, old or debilitated animals.
When propofol is used concomitantly with opioids, an anticholinergic agent (e.g.
atropine) may be used in cases of bradycardia according to the benefit/risk
assessment by the responsible veterinarian. See section 3.8.
Care should be taken when administering the veterinary medicinal product to patients
with hypoproteinaemia, hyperlipidaemia or very thin animals since these animals may
be more susceptible to adverse effects.
Propofol does not have analgesic properties, therefore supplementary analgesic
agents should be provided in cases where procedures are anticipated to be painful.
It has been reported that clearance of propofol is slower and incidence of apnoea is
greater in dogs over 8 years of age than in younger animals. Extra care should be
taken when administering the veterinary medicinal product to these animals, for
example, a lower dose of propofol may be adequate for induction in such cases.
Sighthounds have been reported to show a slower clearance of propofol and may
have a slightly longer duration of recovery from anaesthesia compared to other
breeds of dog.
Use aseptic techniques when administering the veterinary medicinal product as it
does not contain an antimicrobial preservative.

Revised September 2025
AN: 03467/2024 & 03468/2024Page 3 of 9
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Propofol is a potent general anaesthetic drug and particular care should be taken to
avoid accidental self-injection. A guarded needle should preferably be used until the
moment of injection.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet to the physician, but DO NOT DRIVE as sedation may occur.
People with known hypersensitivity to propofol or any of the excipients should avoid
contact with the veterinary medicinal product.
Avoid contact with the skin and eyes as this veterinary medicinal product can cause
irritation.
Wash splashes from skin or eyes immediately with plenty of fresh water. Seek
medical advice if irritation persists.
Advice to the doctor: Do not leave the patient unattended. Maintain airways and
ensure symptomatic and supportive treatment.
Special precautions for the protection of the environment:
Not applicable.