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POM-V Prescription Required Companion Animal

PropoFlo Plus, 10 mg/ml, Emulsion for Injection for Dogs and Cats

Active ingredient: Propofol

Form

Injection

Species

Cats Dogs

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5136

What it's used for

The veterinary medicinal product is indicated for therapeutic use in dogs and cats as a short-acting, intravenous general anaesthetic with a short recovery...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Propofol

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

PropoFlo Plus, 10 mg/ml, Emulsion for Injection for Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

The veterinary medicinal product is indicated for therapeutic use in dogs and cats as a
short-acting, intravenous general anaesthetic with a short recovery period:
For procedures of short duration, lasting up to approximately 5 minutes.
For induction of general anaesthesia where maintenance is provided by inhalation
anaesthetic agents.
For induction and short-term maintenance of general anaesthesia by administration of
incremental doses of the product to effect for approximately half an hour (30 minutes), not
to exceed the total dose stated in section 4.3.

Amended pages: October 2025
AN: 01180/2023
Do not use for prolonged infusion (see section 4.5).
Do not exceed a total dose in one anaesthetic episode of 24 mg/kg (2.4 ml/kg) of propofol
in cats or dogs.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Dogs and cats:
Uncommon (1 to 10 animals /
1,000 animals treated):
Cardiac depression
Respiratory depression
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Injection site reaction
Excitation
1,3
, Behavioural disorder
3,8,9
Hypotension
1,2
Emesis
, Retching
Heinz body anaemia
Nystagmus
, Opisthotonos
, Paddling
, Recovery
prolonged
4,5
, Twitching
1,3,5
Apnoea
1,2
, Panting
, Sneezing
1
During induction
Mild
During recovery
Limiting repeated anaesthesia to intervals of more than 48 hours will reduce the
likelihood.
Associated with the excitation phase.
If inadvertently administered perivascular.
If present before induction, it may continue throughout the subsequent periods of
anaesthesia and recovery.
Observed in cats only.
Observed as paw/face licking.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Amended pages: October 2025
AN: 01180/2023
This product is a stable emulsion; discard the vial if phase separation is observed. Shake
the vial gently but thoroughly before withdrawing a dose.
If this product is injected very slowly, an inadequate plane of anaesthesia can occur.

Special precautions for use in animals
During induction of anaesthesia in any species, mild hypotension and transient apnoea,
similar to effects with other intravenous anaesthetic agents, may occur. Apnoea is most
likely to occur within the first 5 minutes of administration of the product and must be
treated with oxygen and artificial ventilation. Whenever the product is used, facilities
for the maintenance of a patent airway, artificial ventilation and oxygen
supplementation must be immediately available.
As with other intravenous anaesthetic agents, caution should be exercised in dogs and
cats with cardiac, respiratory, renal or hepatic impairment, or in hypovolaemic or
debilitated animals.
The safety of this product has not been established in dogs or cats younger than 5 months
and should be used in these animals only according to the benefit-risk assessment by the
responsible veterinarian
This product should not be used for induction and maintenance of general anaesthesia by
incremental doses that would exceed total dose limits specified in section 4.3
(Contraindications), due to the potential for toxic effects caused by the preservative, benzyl
alcohol (see section 4.10).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Propofol is a potent general anaesthetic drug and particular care should be taken to avoid
accidental self-injection. Use aseptic techniques when administering the product. A
guarded needle should preferably be used until the moment of injection.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician, but DO NOT DRIVE as sedation may occur.

Amended pages: October 2025
AN: 01180/2023
This product may cause hypersensitivity (allergy) reactions. People with known
hypersensitivity to propofol, benzyl alcohol, soya or egg, should avoid contact with the
veterinary medicinal product.
In case of accidental spillage onto the skin or in the eyes wash off immediately with plenty
of water.
To the physician: do not leave the patient unattended. Maintain airways and give
symptomatic and supportive treatment.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.
Propofol has been used after premedication with commonly used premedicants, e.g.
atropine, acepromazine, diazepam, -2 adrenoceptor agents, prior to maintenance with
inhalational agents, e.g. halothane, nitrous oxide, sevoflurane, isoflurane and prior to
administration of analgesic agents, e.g. pethidine, buprenorphine. No pharmacological
incompatibility has been encountered.
The concurrent use of sedative or analgesic drugs is likely to reduce the dose of the
veterinary medicinal product required to produce and maintain anaesthesia. See section
4.9.
Do not freeze.
Keep the vial in the outer carton.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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