Anaestamine 100 mg/ml Solution for Injection

For intravenous and intramuscular use.
In laboratory animals, intraperitoneal use is also possible. Ketamine should be
combined with a sedative.
One dose of 10 mg of ketamine per kg bodyweight corresponds to 0.1 ml of a 100
mg/ml solution per kg bodyweight.
Ketamine can show large inter-individual variation in effect, and therefore dose rates
administered should be tailored to the individual animal, dependent on factors such
as age, condition, and the depth and duration of anaesthesia required.
Before ketamine is administered, please ensure that the animals are adequately
sedated.
DOG
Combination with xylazine or medetomidine
Xylazine (1.1 mg/kg IM) or medetomidine (10 to 30 µg/kg IM) can be used with
Ketamine (5 to 10 mg/kg i.e. 0.5 to 1 ml/10 kg IM) for short term anesthesia of 25 to
40 min. The ketamine dose can be adjusted, depending on the desired duration of
surgery.
CAT
Combination with xylazine
Xylazine (0.5 to 1.1 mg/kg IM) with or without atropine is administered 20 min before
ketamine (11 to 22 mg/kg IM i.e. 0.11 to 0.22 ml/kg IM).

Revised: August 2019
AN: 01376/2018
Combination with medetomidine
Medetomidine (10 to 80 µg/kg IM) can be combined with ketamine (2.5 to 7.5 mg/kg
IM i.e 0.025 to 0.075ml/kg IM). The dose of ketamine should be reduced as the dose
of medetomidine increases.
HORSE
Combination with detomidine:
Detomidine 20 µg/kg IV, after 5 minutes ketamine 2.2 mg/kg fast IV (2.2 ml/100 kg
IV)
Onset of action is gradual, taking approximately 1 minute to attain recumbency, with
duration of anaesthetic effect lasting approximately 10 - 15 minutes.
Combination with xylazine:
Xylazine 1.1 mg/kg IV, followed by ketamine 2.2 mg/kg IV (2.2 ml/100 kg IV)
Onset of action is gradual, taking approximately 1 minute, with duration of
anaesthetic effect being variable and lasting 10 - 30 minutes but usually less than 20
minutes.
After injection the horse lays down spontaneously without any further help. If a
distinct muscle relaxation is required simultaneously, muscle relaxants can be
administered to the recumbent animal, until the horse shows first symptoms of
relaxation.
CATTLE
Combination with xylazine:
Adult cattle can be anesthetized for short periods with xylazine (0.1 to 0.2 mg/kg IV)
followed by ketamine (2 mg/kg IV i.e. 2 ml/100kg IV). The lower dose of xylazine is
used when cattle weigh more than 600 kg. Anesthesia Iasts approximately 30 min but
can be pro-longed for 15 min with additional ketamine (0.75 to 1.25 mg/kg IV i.e. 0.75
to 1.25 ml/100kg IV).
SHEEP
Ketamine 7.5 to 22 mg/kg IV i.e. 0.75 to 2.2 ml/10kg IV depending on the sedative
used.
GOAT
Ketamine 11 to 22 mg/kg IM i.e. 1.1 to 2.2 ml/10kg IM depending on the sedative
used.
PIG
Combination with azaperone:
Ketamine 15 - 20 mg/kg IM (1.5 - 2 ml/10 kg) and 2 mg/kg azaperone IM.
In 4 – 5 month old pigs, following administration of 2 mg/kg azaperone and 20 mg/kg
ketamine IM, the onset of anaesthesia took on average 29 minutes and duration of
effect lasted about 27 minutes.
LABORATORY ANIMALS
Combination with xylazine
Rabbits: xylazine (5-10 mg/kg IM) + ketamine (35-50 mg/kg IM i.e. 0.35 to 0.50 ml/kg
IM)
Rats: xylazine (5-10 mg/kg IP, IM) + ketamine (40-80 mg/kg IP, IM i.e. 0.4-0.8 ml/kg
IP, IM)
Mice: xylazine (7.5-16 mg/kg IP) + ketamine (90-100 mg/kg IP i.e. 0.9 to 1.0 ml/kg IP)

Revised: August 2019
AN: 01376/2018
Guinea pigs: xylazine (0.1 to 5 mg/kg IM) + ketamine (30-80 mg/kg IM i.e. 0.3 to 0.8
ml/kg IM)
Hamster: xylazine (5 to 10 mg/kg IP) + ketamine (50 to 200 mg/kg IP i.e. 0.5 to 2
ml/kg IP)
Dose for maintenance of anaesthesia:
When needed prolongation of effect is possible by repeated administration of an
optionally reduced initial dose.
The vial can be broached up to 20 times. The user should choose the most
appropriate vial size according to the target species to be treated and the
administration route.