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POM-V Prescription Required Companion Animal

Propomitor 10 mg/ml Emulsion for Injection/Infusion for Dogs and Cats

Active ingredient: Propofol

Form

Injection

Species

Cats Dogs

Manufacturer

Orion Corporation

VMD MA No.

06043/5005

What it's used for

- - incremental doses to effect or as a constant rate infusion (CRI). - anaesthetic agents.

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Propofol

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Propomitor 10 mg/ml Emulsion for Injection/Infusion for Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

-
-
incremental doses to effect or as a constant rate infusion (CRI).
-
anaesthetic agents.
Intravenous use.
The veterinary medicinal product is a sterile product for intravenous use.
Shake gently prior to use.
Dose requirements can vary significantly between individual animals and are
influenced by a range of factors (please refer to section 4.5 Special precautions for
use in animals, and section 4.8 Interaction with other medicinal products and other
forms of interaction). In particular, the use of pre-anaesthetic drugs (premedication)
may markedly reduce propofol requirements dependent on the type and dose of pre-
anaesthetic drugs used.
The dose to be administered should be estimated based on average dose
requirements in preparation for anaesthesia. The actual dose requirements of an
individual animal may be significantly lower or higher than the average dose.
Induction
The induction dose of the veterinary medicinal product presented in the table below
is based on data taken from controlled laboratory and field studies and is the average
amount of drug required for dogs or cats to be successfully induced for anaesthesia.
The actual dose administered must be based on the individual response of each
animal.
DOGS
Guide dose
mg/kg bodyweight
Dose volume
ml/kg bodyweight
Unpremedicated6.50.65Premedicated*
alpha-2 agonist
acepromazine-based
3.0
4.5
0.30
0.45
CATSUnpremedicated8.00.8Premedicated*
alpha-2 agonist
acepromazine-based
2.0
6.0
0.2
0.6
* Induction doses significantly below the average dose may be effective after
premedication with an alpha-2 adrenoceptor based protocol in some animals.
When propofol is used in combination with e.g. ketamine, fentanyl or
benzodiazepines for induction of anaesthesia (so called co-induction), the total dose
of propofol can be further reduced.
The dosing syringe should be prepared based on the dose volume of veterinary
medicinal product shown above, calculated based on bodyweight. The dose should
be administered slowly to limit incidence and duration of apnoea and administration

Revised: March 2024
AN: 00180/2023Page 7 of 10
should continue until the clinician is satisfied that the depth of anaesthesia is
sufficient for endotracheal intubation or the planned procedure. As a guide the
veterinary medicinal product should be administered over a period of 20–60 seconds.
Maintenance
Repeat bolus injections
Where anaesthesia is maintained by incremental injections of the veterinary
medicinal product, the dose rate and duration of effect will vary between animals.
The incremental dose required to maintain anaesthesia is typically lower in
premedicated animals compared with unpremedicated animals.
An incremental dose of approximately 1 mg/kg (0.1 ml/kg) in dogs and 2 mg/kg
(0.2 ml/kg) in cats can be administered when anaesthesia becomes too light. This
dose can be repeated as required to maintain an appropriate depth of anaesthesia,
allowing 20–30 seconds between each dose to assess the effect. Each incremental
dose should be administered slowly to effect.
Constant rate infusion
When anaesthesia is maintained by a constant rate infusion (CRI) of propofol, the
dose is 0.2–0.4 mg/kg/min in dogs. The actual dose administered must be based on
the individual response of each animal and may be increased up to 0.6 mg/kg/min for
short periods. In cats, the maintenance dose is 0.1–0.3 mg/kg/min, and should be
adapted to the individual response. CRI anaesthesia lasting up to 2 hours with the
dose 0.4 mg/kg/min in dogs and 0.2 mg/kg/min in cats has been reported to be well
tolerated. In addition, infusion rate may be increased or decreased by 0.025–
0.1 mg/kg/min increments in dogs, or 0.01–0.025 mg/kg/min in cats at 5–10 min
intervals to adapt the anaesthetic plane.
Continuous and prolonged exposure (greater than 30 minutes) may lead to slower
recovery, especially in cats.
Maintenance of anaesthesia by inhalation agents
Where inhalation agents are used to maintain general anaesthesia, it may be
necessary to use a higher initial concentration of the inhalation anaesthetic than is
normally the case following induction with barbiturate agents.
Please refer also to section 4.5 Special precaution for use in animals.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.

Revised: March 2024
AN: 00180/2023Page 2 of 10
Dogs
Very common
(>1 animal / 10 animals treated):
ApnoeaCommon
(1 to 10 animals / 100 animals treated):
Excitation
Arrhythmia, Bradycardia, Hypotension,
Hypertension
a
Emesis, Hypersalivation, Retching
Paddling, Myoclonus, Nystagmus,
Opisthotonus, Recovery prolonged
b
Sneezing
Face/nose rubbing
Uncommon
(1 to 10 animals / 1 000 animals
treated):
Injection site pain
c
Hyperglycemia
a
If propofol is used without premedication as a sole agent in induction of anaesthesia,
a short transient increase of arterial blood pressure can be observed.
b
Slow recovery
c
After intravenous administration
Cats
Very common
(>1 animal / 10 animals treated):
ApnoeaCommon
(1 to 10 animals / 100 animals treated):
Excitation
Arrhythmia, Bradycardia, Hypotension
Emesis, Hypersalivation, Retching
Paddling, Myoclonus, Nystagmus,
Opisthotonos, Recovery prolonged
Sneezing
Face/nose rubbing
Uncommon
(1 to 10 animals / 1 000 animals
treated):
Injection site pain
a
Diarrhoea
b
Facial oedema
b,c
Hyperglycemia, Heinz body anaemia
b
Anorexia
b
a
After intravenous administartion.
b
In cats undergoing repeated anaesthesia. Limiting repeated anaesthesia to intervals
of more than 48 hours will reduce the likelihood. The effects are generally transient
and resolve on their own.

Revised: March 2024
AN: 00180/2023Page 5 of 10
c
Mild facial oedema.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for contact details.
The veterinary medicinal product is a stable emulsion. Prior to use, the veterinary
medicinal product should be inspected visually for absence of visible droplets or
extraneous foreign particles or phase separation, and discarded if present. Do not
use if evidence of phase separation remains after gentle shaking.
If the veterinary medicinal product is injected too slowly an adequate plane of
anaesthesia may not be achieved due to failure to reach the appropriate threshold of
pharmacological activity.

Special precautions for use in animals
During induction of anaesthesia, mild hypotension and transient apnoea may occur.
When using the veterinary medicinal product, facilities for the maintenance of a
patent airway, artificial ventilation and oxygen enrichment must be available.
Following induction of anaesthesia, the use of an endotracheal tube is
recommended. Increased levels of carbon dioxide in blood have been reported with
increased duration of propofol anaesthesia. It is advisable to administer supplemental
oxygen during maintenance of anaesthesia. In addition the need for assisted
ventilation should be considered during prolonged anaesthesia.
If the veterinary medicinal product is injected too rapidly, cardiopulmonary depression
may occur (apnoea, bradycardia, hypotension).
As with other intravenous anaesthetics, caution should be exercised in dogs and cats
with cardiac, respiratory, renal or hepatic impairment, or in hypovolaemic or
debilitated animals.
Propofol may increase blood glucose metabolism and insulin secretion in healthy
dogs. In the absence of safety data in diabetic animals, use only after a benefit/risk
assessment by the veterinarian.
Care should be taken when administering the veterinary medicinal product to patients
with hypoproteinaemia, hyperlipidaemia or very thin animals since these animals may
be more susceptible to adverse effects.
The safety of the veterinary medicinal product has not been established in dogs or
cats younger than 4 months and should be used in these animals only according to
the risk/benefit assessment by the responsible veterinarian.
It has been reported that the clearance of propofol is slower in overweight/obese
animals and dogs over 8 years of age. Extra care should be taken when
administering the veterinary medicinal product to these animals; in particular, a lower
dose of propofol may be adequate for induction and maintenance in such cases.
Sighthounds have been reported to show a slower clearance of propofol and may
have a slightly longer duration of recovery from anaesthesia compared to other
breeds of dog.

Revised: March 2024
AN: 00180/2023Page 3 of 10
Propofol does not have analgesic properties, therefore supplementary analgesic
agents should be provided in cases where procedures are anticipated to be painful.
When propofol is used concomitantly with opioids, an anticholinergic agent (e.g.
atropine) may be used in cases of bradycardia according to the benefit/risk
assessment by the responsible veterinarian. See section 4.8.
Use aseptic techniques when administering the veterinary medicinal product.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Propofol is a potent general anaesthetic drug and particular care should be taken to
avoid accidental self-injection. A guarded needle should preferably be used until the
moment of injection.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician, but DO NOT DRIVE as sedation may
occur.
This veterinary medicinal product may cause hypersensitivity (allergy) reactions in
those that are already sensitised to propofol, soya or egg. People with known
hypersensitivity to these substances should avoid contact with the veterinary
medicinal product.
Avoid contact with the skin and eyes as the veterinary medicinal product can cause
irritation.
Wash off splashes from skin or eyes immediately with plenty of fresh water. If
irritation persists, seek medical advice and show the package leaflet/label to the
physician.
To the physician:
Do not leave the patient unattended. Maintain airways and give symptomatic and
supportive treatment.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.

Revised: March 2024
AN: 00180/2023Page 4 of 10
Propofol may be used in association with premedicants, e.g. atropine, glycopyrrolate,
-2 agonists (medetomidine, dexmedetomidine), acepromazine, benzodiazepines
(diazepam, midazolam); inhalational agents (e.g. halothane, isoflurane, sevoflurane,
enflurane and nitrous oxide); and analgesic agents such as pethidine and
buprenorphine.
The veterinary medicinal product may be administered parallel to all intravenous
fluids via e.g. a Y-piece positioned near the injection site. The veterinary medicinal
product can be diluted with 5% glucose infusion solution. Compatibility studies with
other infusion solutions (e.g. NaCl or lactated Ringer’s solution) have not been
conducted with this veterinary medicinal product.
The concurrent use of sedative or analgesic drugs is likely to reduce the dose of
propofol required to induce and maintain anaesthesia. See section 4.9.
Concomitant use of propofol and opioids may cause significant respiratory
depression and a profound decrease in heart rate. In cats, concurrent use of propofol
and ketamine have been reported to cause apnoea more frequently than propofol
and other premedicants. To reduce the risk of apnoea, propofol should be
administered slowly over 20–60 seconds. See also section 4.5.
Co-administration of propofol and opioid (e.g. fentanyl, alfentanil) infusions for
maintenance of general anaesthesia may result in a prolonged recovery. Cardiac
arrest has been observed in dogs that received propofol followed by alfentanil.
Administration of propofol with other medicinal products that are metabolised by
cytochrome P450 (isoenzyme 2B11 in the dog) such as chloramphenicol,

Revised: March 2024
AN: 00180/2023Page 6 of 10
ketoconazole and loperamide reduces propofol clearance and prolongs recovery
from anaesthesia.
Do not freeze. Keep the vial in the outer carton.
Co-administration of propofol and opioid (e.g. fentanyl, alfentanil) infusions for
maintenance of general anaesthesia may result in a prolonged recovery. Cardiac
arrest has been observed in dogs that received propofol followed by alfentanil.
Administration of propofol with other medicinal products that are metabolised by
cytochrome P450 (isoenzyme 2B11 in the dog) such as chloramphenicol,

Revised: March 2024
AN: 00180/2023Page 6 of 10
ketoconazole and loperamide reduces propofol clearance and prolongs recovery
from anaesthesia.
4.9 Amounts to be administered and administration route
Intravenous use.
The veterinary medicinal product is a sterile product for intravenous use.
Shake gently prior to use.
Dose requirements can vary significantly between individual animals and are
influenced by a range of factors (please refer to section 4.5 Special precautions for
use in animals, and section 4.8 Interaction with other medicinal products and other
forms of interaction). In particular, the use of pre-anaesthetic drugs (premedication)
may markedly reduce propofol requirements dependent on the type and dose of pre-
anaesthetic drugs used.
The dose to be administered should be estimated based on average dose
requirements in preparation for anaesthesia. The actual dose requirements of an
individual animal may be significantly lower or higher than the average dose.
Induction
The induction dose of the veterinary medicinal product presented in the table below
is based on data taken from controlled laboratory and field studies and is the average
amount of drug required for dogs or cats to be successfully induced for anaesthesia.
The actual dose administered must be based on the individual response of each
animal.
DOGS
Guide dose
mg/kg bodyweight
Dose volume
ml/kg bodyweight
Unpremedicated

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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