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AVM-GSL Over the Counter Companion Animal

Pet Shield Flea Screen Combo 50 mg/60 mg Spot on Solution Cats

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Cats

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/4124

What it's used for

To be used against infestations with fleas, alone or in association with ticks and/or biting lice: -Ctenocephalides spp.). Insecticidal efficacy against ne...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Pet Shield Flea Screen Combo 50 mg/60 mg Spot on Solution Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

To be used against infestations with fleas, alone or in association with ticks and/or
biting lice:
-Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for six weeks after
application.
-Ixodes ricinus, Dermacentor variabilis, Rhipicephalus
sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks
against ticks (based on experimental data).
-Felicola subrostratus).
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible. Place the tip of the pipette onto the skin
and squeeze the pipette several times to empty its contents completely and
directly onto the skin in one spot.

Revised December 2024
AN: 00151/2024
In the absence of available data, the product should not be used on kittens less than
8 weeks old and/or weighing less than 1 kg.

Revised December 2024
AN: 00151/2024
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use if your cat has a hypersensitivity to fipronil or S-methoprene or the other
ingredients.
Do not use in rabbits, as adverse drug reactions with even mortality could
occur.
Do not use in any other non-target species.
Do not overdose.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use. Excessive salivation, reversible nervous signs
(increased sensitivity to stimulation, depression, other nervous signs) or vomiting
have also been observed after use.
In the case of licking the administration site, a brief period of excessive salivation
may be observed due mainly to the nature of the carrier.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time. Fleas from pets often infest the animal's
basket, bedding and regular resting areas such as carpets and soft furnishings which
should be treated, in case of massive infestation and at the beginning of the control
measures, with a suitable insecticide and vacuumed regularly.
Bathing and/or shampooing should be avoided. No information on the effect of
bathing or the use of a shampoo on the effectiveness of the product in cats is
available. Based on information available for dogs, bathing/immersion in water within
2 days after application of the product and more frequent bathing than once a week
should be avoided.

i) Special precautions for use in animals
Avoid contact with the animal’s eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product. Avoid contents coming into contact with the fingers. If this
occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully in clean water.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet to the physician.
Wash hands after use.
Do not smoke, drink or eat during application.

Revised December 2024
AN: 00151/2024
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Keep pipettes in original packaging until ready to use.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
This veterinary medicinal product does not require any special temperature storage
conditions. Store in the original package in order to protect from light and moisture.

Revised December 2024
AN: 00151/2024
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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